PURPOSE Many patients in primary care require anticoagulation with warfarin for the
prevention of venous and systemic embolism. Achieving the goal international normalized ratio (…

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …

To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find
associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced …

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …

Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Background Sex differences in incidence and/or presentation of schizophrenia (SCZ), major
depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for …

Genetic risk prediction has several potential applications in medical research and clinical
practice and could be used, for example, to stratify a heterogeneous population of patients by …

Genetic correlation is a key population parameter that describes the shared genetic architecture
of complex traits and diseases. It can be estimated by current state-of-art methods, ie, …

Importance About 20% to 30% of people with schizophrenia have psychotic symptoms that
do not respond adequately to first-line antipsychotic treatment. This clinical presentation, …