Background Once-daily injections of parathyroid hormone or its amino-terminal fragments
increase bone formation and bone mass without causing hypercalcemia, but their effects on …

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

Trabecular bone score (TBS) is a gray‐level textural index of bone microarchitecture derived
from lumbar spine dual‐energy X‐ray absorptiometry (DXA) images. TBS is a bone mineral …

The 3‐year FREEDOM trial assessed the efficacy and safety of 60 mg denosumab every 6
months for the treatment of postmenopausal women with osteoporosis. Participants who …

Several recent studies suggest that obesity may be a risk factor for fracture. The aim of this
study was to investigate the association between body mass index (BMI) and future fracture …

The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare (MAF
≤ 1%) variants contribute to complex traits and disease in the general population is …

The osteoblast‐derived protein osteocalcin has recently been shown to affect adiposity and
glucose homeostasis in mice, suggesting that the skeleton influences energy metabolism …

Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with
high arterial blood pressure and hypertension risk, but whether this association is causal is …

Genome-wide association studies have identified 32 loci influencing body mass index, but
this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-…

Context: The Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months
(FREEDOM) extension is evaluating the long-term efficacy and safety of denosumab for up …