Background Frailty can be measured in relation to the accumulation of deficits using a frailty
index. A frailty index can be developed from most ageing databases. Our objective is to …

Background: Little is known about the natural course of frailty. We performed a prospective
study to determine the transition rates between frailty states and to evaluate the effect of the …

Background Despite the importance of functional status to older persons and their families,
little is known about the course of disability at the end of life. Methods We evaluated data on …

Context Disability among older persons is a complex and highly dynamic process, with high
rates of recovery and frequent transitions between states of disability. The role of intervening …

Background: Restricted activity is a potentially important indicator of health and functional
status. Yet, relatively little is known about the incidence, precipitants, or health care utilization …

Importance Little is known about functional trajectories of older persons in the year before and
after admission to the intensive care unit (ICU) or how pre-ICU functional trajectories affect …

Little is known about the deleterious effects of injurious falls relative to those of other disabling
conditions or whether these effects are driven largely by hip fractures. From a cohort of …

Background. Frailty among older persons is a dynamic process, characterized by frequent
transitions between frailty states over time. We performed a prospective longitudinal study to …

Background: Relatively little is known about why older persons develop long-term disability
in community mobility. Objective: To identify the risk factors and precipitants for long-term …

Background Frailty is a strong indicator of vulnerability among older persons, but its
association with ICU outcomes has not been evaluated prospectively (ie, with objective …