Effect of screening on ovarian cancer mortality: the prostate, lung, colorectal and ovarian (PLCO) cancer screening randomized controlled trial

…, CS Zhu, G Izmirlian, BS Kramer, AB Miller, JL Xu… - Jama, 2011 - jamanetwork.com
Context Screening for ovarian cancer with cancer antigen 125 (CA-125) and transvaginal
ultrasound has an unknown effect on mortality. Objective To evaluate the effect of screening for …

Results from four rounds of ovarian cancer screening in a randomized trial

…, RT Greenlee, C Williams, JL Xu… - Obstetrics & …, 2009 - journals.lww.com
OBJECTIVE: To test whether annual screening with transvaginal ultrasonography and CA
125 reduces ovarian cancer mortality. METHODS: Data from the first four annual screens, …

Cumulative incidence of false-positive results in repeated, multimodal cancer screening

…, AR Kreimer, PC Prorok, JL Xu… - The Annals of Family …, 2009 - Annals Family Med
PURPOSE Multiple cancer screening tests have been advocated for the general population;
however, clinicians and patients are not always well-informed of screening burdens. We …

The epidemiology of CA-125 in women without evidence of ovarian cancer in the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial

…, B Kessel, TL Riley, LR Ragard, CR Williams, JL Xu… - Gynecologic …, 2008 - Elsevier
OBJECTIVE: To determine the epidemiology of CA-125 in women without ovarian cancer.
METHODS: We analyzed demographic, medical and lifestyle characteristics related to CA-125…

Longitudinal evaluation of CA-125 velocity and prediction of ovarian cancer

JL Xu, J Commins, E Partridge, TL Riley, PC Prorok… - Gynecologic …, 2012 - Elsevier
OBJECTIVE: To determine whether CA-125 velocity is a statistically significant predictor of
ovarian cancer and develop a classification rule to screen for ovarian cancer. METHODS: In …

Assessing the risk of ovarian malignancy in asymptomatic women with abnormal CA 125 and transvaginal ultrasound scans in the prostate, lung, colorectal, and …

…, TL Riley, J Commins, L Ragard, JL Xu… - Obstetrics & …, 2013 - journals.lww.com
OBJECTIVE: To estimate the risk of ovarian malignancy among asymptomatic women with
abnormal transvaginal ultrasound scans or CA 125 and to provide guidance to physicians …

Non‐parametric estimation of the post‐lead‐time survival distribution of screen‐detected cancer cases

JL Xu, PC Prorok - Statistics in Medicine, 1995 - Wiley Online Library
The goal of screening programmes for cancer is early detection and treatment with a consequent
reduction in mortality from the disease. Screening programmes need to assess the true …

Estimating the cumulative risk of a false-positive test in a repeated screening program

JL Xu, RM Fagerstrom, PC Prorok, BS Kramer - Biometrics, 2004 - academic.oup.com
The goal of screening tests for a chronic disease such as cancer is early detection and
treatment with a consequent reduction in mortality from the disease. Screening tests, however, …

Estimation of post‐lead‐time survival under dependence between lead‐time and post‐lead‐time survival

JL Xu, RM Fagerstrom, PC Prorok - Statistics in medicine, 1999 - Wiley Online Library
Early detection of cancer by screening advances the date of diagnosis, but may or may not
alter time to death. Screening programme need to assess the true benefit of screening, that is, …

Estimating a distribution function of the tumor size at metastasis

JL Xu, PC Prorok - Biometrics, 1998 - JSTOR
In studying the relationship between the size of primary cancers and the occurrence of
metastases, two quantities are of prime importance. The first is the distribution of tumor size at the …