Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells
implement a complex pro-inflammatory response termed the senescence-associated secretory …

Background Multiple major health organisations recommend the use of extracorporeal
membrane oxygenation (ECMO) support for COVID-19-related acute hypoxaemic respiratory …

Although it is generally accepted that cellular differentiation requires changes to transcriptional
networks, dynamic regulation of promoters and enhancers at specific sets of genes has …

Mammalian chromosomes fold into arrays of megabase‐sized topologically associating
domains ( TAD s), which are arranged into compartments spanning multiple megabases of …

Polycomb repressor complexes (PRCs) are important chromatin modifiers fundamentally
implicated in pluripotency and cancer. Polycomb silencing in embryonic stem cells (ESCs) can …

In the FANTOM5 project, transcription initiation events across the human and mouse genomes
were mapped at a single base-pair resolution and their frequencies were monitored by …

Follicular lymphoma has considerable clinical heterogeneity, and there is a need for easily
quantifiable prognostic biomarkers. Microvessel density has been shown to be a useful …

Differentiated cells can be reprogrammed through the formation of heterokaryons and
hybrid cells when fused with embryonic stem (ES) cells. Here, we provide evidence that …

Since the DJeclaration of Helsinki was originally published in 1964 by the World Medical
Association (WMA), its primary purpose has been to set international ethical principles for …

PURPOSE Patient satisfaction is an important health care outcome. This study compared
patients’ satisfaction with care received for an urgent health problem from their family physician…