Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and …

…, A Meier, IH Yuk, N Vijayasankaran, K Leach… - Journal of …, 2011 - Elsevier
Large-scale fed-batch cell culture processes of CHO cells are the standard platform for the
clinical and commercial production of monoclonal antibodies. Lactate is one of the major by-…

Controlling glycation of recombinant antibody in fed‐batch cell cultures

…, B Zhang, Y Yang, G Dutina, KD Leach… - Biotechnology and …, 2011 - Wiley Online Library
Protein glycation is a non‐enzymatic glycosylation that can occur to proteins in the human
body, and it is implicated in the pathogenesis of multiple chronic diseases. Glycation can also …

Drivers of scope of practice in family medicine: a conceptual model

…, S Kimmel, K Franke, K Leach… - The Annals of Family …, 2021 - Annals Family Med
PURPOSE The purpose of this study was to explore family medicine graduates’ attitudes and
perspectives on modifiable and unmodifiable factors that influenced their scope of practice …

Family inclusion in diabetes education: a nationwide survey of diabetes educators

…, LJ Ware, H Raffle, K Leach - The Diabetes …, 2011 - journals.sagepub.com
Purpose The purpose of this study was to investigate perceptions about family inclusion and
support in diabetes self-management education. Methods Surveys were mailed to certified …

Methods and strategies for effectively surveying the LGBTQ+ population

P Hughes, C Harless, K Leach - Research in Social and Administrative …, 2021 - Elsevier
The Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ) population is at a substantially
elevated risk for myriad health complications, due in large part to structural and social …

[HTML][HTML] Cell culture efforts to reduce glycation in recombinant humanized antibody

IH Yuk, H Huynh, K Leach, A Shen, B Zhang… - Microbial Cell …, 2006 - Springer
Background Glycation is a common post-translational modification of proteins, resulting from
the chemical reaction between reducing sugars such as glucose and the primary amino …

Cancer statistics for adults aged 85 years and older, 2019

…, SG Mohile, HJ Cohen, CR Leach… - CA: a cancer journal …, 2019 - Wiley Online Library
Adults aged 85 years and older, the “oldest old,” are the fastest‐growing age group in the
United States, yet relatively little is known about their cancer burden. Combining data from the …

[HTML][HTML] Engineering 100, Section 103, Group 3

JD Burr, GW Fiorani, KF Leach, RH Lin - Orbit - angelfire.com
2. Summary We have analyzed and compared three systems for astronomical observation:
the OverWhelmingly Large Telescope, a ground-based system; the Chandra X-Ray …

Real-time resolution of point mutations that cause phenovariance in mice

…, S Arnett, K Hawkins, A Leach… - Proceedings of the …, 2015 - National Acad Sciences
With the wide availability of massively parallel sequencing technologies, genetic mapping
has become the rate limiting step in mammalian forward genetics. Here we introduce a …

Capacity-building: How a multidisciplinary team empowered school nurses to conduct research

K Leach, D Carpenter, K Thomas… - … Annual Meeting and …, 2020 - apha.confex.com
The significance of this work is to 1) build capacity of school nurses to engage in research,
and 2) inform and improve school nurse practice and delivery of mental health care to …