SARS-CoV-2 detection, viral load and infectivity over the course of an infection

…, S Ahern, PG Carty, KK O'Brien, E O'Murchu, M O'Neill… - Journal of Infection, 2020 - Elsevier
Objectives To summarise the evidence on the detection pattern and viral load of SARS-CoV-2
over the course of an infection (including any asymptomatic or pre-symptomatic phase), …

[HTML][HTML] The Alvarado score for predicting acute appendicitis: a systematic review

R Ohle, F O'Reilly, KK O'Brien, T Fahey, BD Dimitrov - BMC medicine, 2011 - Springer
Background The Alvarado score can be used to stratify patients with symptoms of suspected
appendicitis; the validity of the score in certain patient groups and at different cut points is …

Immune response following infection with SARS‐CoV‐2 and other coronaviruses: a rapid review

…, K Jordan, M Keoghan, KK O'Brien… - Reviews in medical …, 2021 - Wiley Online Library
In this review, we systematically searched and summarized the evidence on the immune
response and reinfection rate following SARS‐CoV‐2 infection. We also retrieved studies on …

Evaluating the association between low-density lipoprotein cholesterol reduction and relative and absolute effects of statin treatment: a systematic review and meta …

…, M Demasi, M Jones, SM Smith, KK O'Brien… - JAMA internal …, 2022 - jamanetwork.com
Importance The association between statin-induced reduction in low-density lipoprotein
cholesterol (LDL-C) levels and the absolute risk reduction of individual, rather than composite, …

[HTML][HTML] … streptococcal pharyngitis in adults in primary care: a systematic review of the diagnostic accuracy of symptoms and signs and validation of the Centor score

J Aalbers, KK O'Brien, WS Chan, GA Falk, C Teljeur… - BMC medicine, 2011 - Springer
Background Stratifying patients with a sore throat into the probability of having an underlying
bacterial or viral cause may be helpful in targeting antibiotic treatment. We sought to assess …

Validity of British Thoracic Society guidance (the CRB-65 rule) for predicting the severity of pneumonia in general practice: systematic review and meta-analysis

M McNally, J Curtain, KK O'Brien, BD Dimitrov… - British Journal of …, 2010 - bjgp.org
Background The CRB-65 score is a clinical prediction rule that grades the severity of
community-acquired pneumonia in terms of 30-day mortality. Aim The study sought to validate CRB-…

[HTML][HTML] Comparison of self-reported health & healthcare utilisation between asylum seekers and refugees: an observational study

M Toar, KK O'Brien, T Fahey - BMC public health, 2009 - Springer
Background Adult refugees and asylum seekers living in Western countries experience a
high prevalence of mental health problems, especially post traumatic stress disorder (PTSD), …

[HTML][HTML] Health and use of health services of people who are homeless and at risk of homelessness who receive free primary health care in Dublin

C Keogh, KK O'Brien, A Hoban, A O'Carroll… - BMC health services …, 2015 - Springer
Background Homeless populations experience poorer physical and mental health, and
more barriers to accessing adequate healthcare. This study investigates the health of this …

A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency

A Parle‐McDermott, F Pangilinan, KK O'Brien… - Human …, 2009 - Wiley Online Library
Polymorphisms in folate‐related genes have emerged as important risk factors in a range of
diseases including neural tube defects (NTDs), cancer, and coronary artery disease (CAD). …

[HTML][HTML] Using preprints in evidence synthesis: Commentary on experience during the COVID-19 pandemic

…, E O'Murchu, MK Sharp, L Comber, KK O'Brien… - Journal of Clinical …, 2021 - Elsevier
Evidence syntheses are increasingly drawing on preprint servers as a source for emergent
literature on COVID-19. Our research group, has conducted a large number of rapid reviews …