Informed consent-as an ethical ideal and legal doctrine-has been the source of much concern
to clinicians. Drawing on a diverse set of backgrounds and two decades of research in …

Researchers, institutional review boards (IRBs), participants in human subjects research,
and their families face an important but largely neglected problem — how should incidental …

Biobanks and archived data sets collecting samples and data have become crucial engines
of genetic and genomic research. Unresolved, however, is what responsibilities biobanks …

Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection
and inflammation to provide early defence against invading microorganisms. This function …

The Precision Medicine Initiative (PMI) is an innovative approach to developing a new
model of health care that takes into account individual differences in people’s genes, …

Neutrophils are amongst the first immune cells to arrive at sites of infection, where they initiate
antimicrobial and proinflammatory functions, which serve to contain infection. Sensing and …

Background Reducing the transmission of severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) is a global priority. Contact tracing identifies people who were recently in …

What accounts for differences in HIV stigma across different high prevalence settings? This
study was designed to examine HIV stigma and discrimination in five high prevalence settings…

The regulation of neutrophil lifespan by induction of apoptosis is critical for maintaining an
effective host response and preventing excessive inflammation. The hypoxia-inducible factor (…

Interleukin (IL)‐1 is an important mediator of acute brain injury and inflammation, and has
been implicated in chronic neurodegeneration. The main source of IL‐1 in the CNS is …