The question of how to analyze unbalanced or incomplete repeated-measures data is a
common problem facing analysts. We address this problem through maximum likelihood …

ContextSleep-disordered breathing (SDB) is both prevalent and associated with serious chronic
illness. The incidence of SDB and the effect of risk factors on this incidence are unknown…

Background Polymorphisms in genes other than the cystic fibrosis transmembrane conductance
regulator (CFTR) gene may modify the severity of pulmonary disease in patients with …

This paper describes the problem of informative censoring in longitudinal studies where the
primary outcome is rate of change in a continuous variable. Standard approaches based on …

OBJECTIVE: To examine whether risperidone is superior to placebo in the treatment of youths
with conduct disorder. METHOD: This was a 10-week, randomized, double-blind, placebo-…

Maximum likelihood procedures for analysing mixed continuous and categorical data with
missing values are presented. The general location model of 01kin & Tate (1961) and …

To assess the utility and precision of GFR measurements in multicenter trials, the test
performance and variability of GFR were analyzed in 2,250 patients enrolled in 44 clinical centers …

Longitudinal studies often gather joint information on time to some event (survival analysis,
time to dropout) and serial outcome measures (repeated measures, growth curves). …

BACKGROUND: After a colonoscopy that is negative for cancer, a subset of patients may be
diagnosed with colorectal cancer, also termed interval cancer. The frequency and predictors …

Rationale: High-dose ibuprofen in a 4-year controlled trial slowed FEV 1 decline in young
subjects with cystic fibrosis, but the effectiveness of ibuprofen has not been assessed in a …