Background Only a few small studies have assessed the long-term morbidity that follows the
treatment of childhood cancer. We determined the incidence and severity of chronic health …

Importance Adult survivors of childhood cancer are known to be at risk for treatment-related
adverse health outcomes. A large population of survivors has not been evaluated using a …

ContextAdult survivors of childhood cancer are at risk for medical and psychosocial sequelae
that may adversely affect their health status.ObjectivesTo compare the health status of …

Survival rates for most paediatric cancers have improved at a remarkable pace over the past
four decades. In developed countries, cure is now the probable outcome for most children …

The Children’s Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood,
Adolescent, and Young Adult Cancers are risk-based, exposure-related clinical practice …

Background Survivors of childhood cancer develop early and severe chronic health
conditions (CHCs). A quantitative landscape of morbidity of survivors, however, has not been …

St Jude Total Therapy Study XIIIB for childhood acute lymphoblastic leukemia (ALL)
incorporated more stringent risk classification, early intensification of intrathecal chemotherapy, …

Background Among patients in whom childhood cancer was diagnosed in the 1970s and
1980s, 18% of those who survived for 5 years died within the subsequent 25 years. In recent …

Background Adult survivors of childhood central nervous system (CNS) malignancies are at
high risk for long-term morbidity and late mortality. However, patterns of late mortality, the …

Background Children who survive acute lymphoblastic leukemia are at risk for leukemia-related
or treatment-related complications, which can adversely affect survival and …