User profiles for Rebecca K. Simmons

Dr Rebecca K Simmons, BA (Hons), MSc, PhD

- Verified email at riverlane.com - Cited by 8496

Rebecca K Simmons

- Verified email at research.uwa.edu.au - Cited by 1566

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation

…, G Sun, XY Choo, C McLean, RK Simmons… - Nature …, 2019 - nature.com
There is currently little information available about how individual cell types contribute to
Alzheimer’s disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …

[HTML][HTML] Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe …

…, GEHM Rutten, A Sandbæk, SJ Sharp, RK Simmons… - The Lancet, 2011 - thelancet.com
Background Intensive treatment of multiple cardiovascular risk factors can halve mortality
among people with established type 2 diabetes. We investigated the effect of early …

Prediction of childhood obesity by infancy weight gain: an individual‐level meta‐analysis

…, N Stettler, S Sharp, RK Simmons… - Paediatric and …, 2012 - Wiley Online Library
Druet C, Stettler N, Sharp S, Simmons RK, Cooper C, Davey Smith G, Ekelund U, Lévy‐Marchal
C, Jarvelin M‐R, Kuh D, Ong KK. Prediction of childhood obesity by infancy weight gain: …

[HTML][HTML] Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows

…, T Lassmann, D Poppe, O Clément, RK Simmons… - Genome biology, 2020 - Springer
Background Single-cell RNA sequencing has been widely adopted to estimate the cellular
composition of heterogeneous tissues and obtain transcriptional profiles of individual cells. …

Risk assessment tools for identifying individuals at risk of developing type 2 diabetes

B Buijsse, RK Simmons, SJ Griffin… - Epidemiologic …, 2011 - academic.oup.com
Trials have demonstrated the preventability of type 2 diabetes through lifestyle modifications
or drugs in people with impaired glucose tolerance. However, alternative ways of identifying …

Early detection and treatment of type 2 diabetes reduce cardiovascular morbidity and mortality: a simulation of the results of the Anglo-Danish-Dutch study of intensive …

…, SJ Griffin, RK Simmons, MJ Davies, K Khunti… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE To estimate the benefits of screening and early treatment of type 2 diabetes
compared with no screening and late treatment using a simulation model with data from the …

[HTML][HTML] Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial

RK Simmons, JB Echouffo-Tcheugui, SJ Sharp… - The Lancet, 2012 - thelancet.com
Background The increasing prevalence of type 2 diabetes poses a major public health
challenge. Population-based screening and early treatment for type 2 diabetes could reduce this …

[PDF][PDF] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution

CA Herring, RK Simmons, S Freytag, D Poppe… - Cell, 2022 - cell.com
Human brain development is underpinned by cellular and molecular reconfigurations continuing
into the third decade of life. To reveal cell dynamics orchestrating neural maturation, we …

A simple risk score identifies individuals at high risk of developing Type 2 diabetes: a prospective cohort study

M Rahman, RK Simmons, AH Harding… - Family …, 2008 - academic.oup.com
Background. Randomized trials have demonstrated that Type 2 diabetes is preventable
among high-risk individuals. To date, such individuals have been identified through population …

Which behavior change techniques are associated with changes in physical activity, diet and body mass index in people with recently diagnosed diabetes?

…, S Sutton, AT Prevost, RK Simmons… - Annals of Behavioral …, 2015 - academic.oup.com
Background Meta-analyses have identified promising behavior change techniques (BCTs)
in changing obesity-related behaviors from intervention descriptions. However, it is unclear …