Introduces a new approach to rock mechanics called``block theory,''which formalizes
procedures for selecting proper shapes and orientations for excavations in hard jointed rock. …

The representation of discontinuities in analysis of blocky rock is discussed. A linkage type
element is developed for addition of rock joint stiffness to the structural stiffness matrix …

CYCLIC AMP-regulated gene expression frequently involves a DNA element known as the
cAMP-regulated enhancer (CRE) 1–4 . Many transcription factors bind to this element, …

THE transcription factor CREB binds to a DNA element known as the cAMP-regulated
enhancer (CRE) 1–5 . CREB is activated through phosphorylation by protein kinase A (PKA) 6 , …

CREB binding protein (CBP) and p300 were both identified initially in protein interaction
assays–the former through its association with the transcription factor CREB (Chrivia et al. 1993…

With non-communicable conditions accounting for nearly two-thirds of deaths worldwide, the
emergence of chronic diseases as the predominant challenge to global health is undisputed…

We have examined the regulation of somatostatin gene expression by cAMP in PC12 rat
pheochromocytoma cells transfected with the rat somatostatin gene. Forskolin at 10 microM …

THE Rubinstein-Taybi syndrome (RTS) is a well-defined syndrome with facial abnormalities,
broad thumbs, broad big toes and mental retardation as the main clinical features 1-3 . …

The objective of this research was to update earlier estimates of prevalence rates of single
chronic conditions and multiple (> 2) chronic conditions (MCC) among the noninstitutionalized…

This work on rock mechanics points toward the practical applications of interest to tunnelers,
miners, and foundation engineers. It is about the ''geometric facts of intersecting …