The fragmented nature of modern working life is leading to fundamental changes in our
understanding of the term career. Few people now expect to have a lifetime of continuous …

Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes
that define cell identity. Improved understanding of the roles that super-enhancers play in …

Developmental programs are controlled by transcription factors and chromatin regulators,
which maintain specific gene expression programs through epigenetic modification of the …

We describe the results of a genome-wide analysis of human cells that suggests that most
protein-coding genes, including most genes thought to be transcriptionally inactive, …

Tumour oncogenes include transcription factors that co-opt the general transcriptional
machinery to sustain the oncogenic state 1 , but direct pharmacological inhibition of transcription …

We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …

The transcription factors OCT4, SOX2, and NANOG have essential roles in early development
and are required for the propagation of undifferentiated embryonic stem (ES) cells in …

Eukaryotic genomes are packaged into nucleosomes, which are thought to repress gene
expression generally 1 , 2 , 3 . Repression is particularly evident at yeast telomeres, where …

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DNA-binding transcriptional regulators interpret the genome's regulatory code by binding to
specific sequences to induce or repress gene expression 1 . Comparative genomics has …