Objective To identify the most commonly presenting conditions in primary care globally, and
to compare common reasons for visits (RFVs) as reported by clinicians and patients, as well …

Background Skeletal muscle cramps are common and often occur in association with
pregnancy, advanced age, exercise or motor neuron disorders (such as amyotrophic lateral …

Objective To determine the quality of health recommendations and claims made on popular
medical talk shows. Design Prospective observational study. Setting Mainstream television …

Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood
pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of …

Background Eight out of 10 major antihypertensive trials in older adults attempted to
achieve a target systolic blood pressure (BP) less than 160 mmHg. Collectively these trials …

Background The use of diuretics, statins, and inhaled long-acting β2-agonists (LABAs) is
linked to muscle cramps but largely by anecdotal evidence. This study sought population-level …

Objective To develop clinical practice guidelines for a simplified approach to primary
prevention of cardiovascular disease (CVD), concentrating on CVD risk estimation and lipid …

Introduction Sleep-time blood pressure correlates more strongly with adverse cardiovascular
events than does daytime blood pressure. The BedMed trial evaluates whether bedtime …

Lipopolysaccharide responsiveness in human subjects was assessed through the examination
of LPS‐stimulated PGE 2 and IL‐1/β release from counterflow isolated monocytes from …

Objective To develop a clinical practice guideline to support the management of chronic
pain, including low back, osteoarthritic, and neuropathic pain in primary care. Methods The …