Objective: Decades-old, common ICU practices including deep sedation, immobilization, and
limited family access are being challenged. We endeavoured to evaluate the relationship …

Although advances in intensive care have enabled more patients to survive an acute critical
illness, they also have created a large and growing population of chronically critically ill …

Context Studies suggest that many survivors of critical illness experience long-term cognitive
impairment but have not included premorbid measures of cognitive functioning and have …

Background There are conflicting data on the effects of antipsychotic medications on delirium
in patients in the intensive care unit (ICU). Methods In a randomized, double-blind, placebo…

Objective: To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for
delirium in the intensive care unit and to test the hypothesis that antipsychotics would improve …

Background: Growing numbers of critically ill patients receive prolonged mechanical ventilation.
Little is known about the patterns of care as patients transition from acute care hospitals …

Objective. —To compare the effects of change from an open to a closed intensive care unit (ICU)
format on clinical outcomes, resource utilization, teaching, and perceptions regarding …

Objectives: The epidemiology of chronic critical illness is not well characterized. We sought
to determine the prevalence, outcomes, and associated costs of chronic critical illness in the …

Objective: To compare duration of mechanical ventilation for patients randomized to receive
lorazepam by intermittent bolus administration vs. continuous infusions of propofol using …

Objective: To compare prolonged mechanical ventilation decision-makers’ expectations for
long-term patient outcomes with prospectively observed outcomes and to characterize …