The chronic care model is a guide to higher-quality chronic illness management within
primary care. The model predicts that improvement in its 6 interrelated components—self-…

The Triple Aim—enhancing patient experience, improving population health, and reducing
costs—is widely accepted as a compass to optimize health system performance. Yet …

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Dr. Thomas Bodenheimer writes that primary care is facing a confluence of factors that could
spell disaster. Patients are increasingly dissatisfied, many primary care physicians are …

This article reviews research evidence showing to what extent the chronic care model can
improve the management of chronic conditions (using diabetes as an example) and reduce …

Patients with chronic conditions make day-to-day decisions about—self-manage—their
illnesses. This reality introduces a new chronic disease paradigm: the patient-professional …

Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …

We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive
breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, …