Macrophage activation is associated with profound transcriptional reprogramming. Although
much progress has been made in the understanding of macrophage activation, polarization, …

The Patient-Centered Clinical Method (PCCM) has been a core tenet of the practice and
teaching of medicine since the first edition of Patient-Centered Medicine-Transforming the …

Fourteen years after transplantation into the striatum of an individual with Parkinson's
disease, grafted nigral neurons were found to have Lewy body–like inclusions that stained …

Thirty‐four patients with advanced Parkinson's disease participated in a prospective 24‐month
double‐blind, placebo‐controlled trial of fetal nigral transplantation. Patients were …

Highly successful in its first two editions, McWhinney's Textbook of Family Medicine is one of
the seminal texts in the field. While many family medicine texts simply cover the disorders a …

Background Trials are under way to determine whether fetal nigral grafts can improve motor
function in patients with Parkinson's disease. Some studies use fluorodopa uptake on …

Retrotransposons are mobile genetic elements that use a germline ‘copy-and-paste’ mechanism
to spread throughout metazoan genomes 1 . At least 50 per cent of the human genome …

Background Cannabis use is associated with increased risk of later psychotic disorder but
whether it affects incidence of the disorder remains unclear. We aimed to identify patterns of …

Although it is generally accepted that cellular differentiation requires changes to transcriptional
networks, dynamic regulation of promoters and enhancers at specific sets of genes has …

We performed fetal nigral transplantations in 4 Parkinson's disease (PD) patients. Solid grafts
were bilaterally implanted into the postcommissural putamen using 3 to 4 donors per side …