In striated muscle, the number of capillaries containing moving red blood cells increases
with increasing metabolic demand. This phenomenon, termed capillary recruitment, has long …

Key points Theoretical models suggest there is no benefit of high affinity haemoglobin to
preserve maximal oxygen uptake in acute hypoxia but the comparative biology literature has …

The oxygen transport cascade describes the physiological steps that bring atmospheric oxygen
into the body where it is delivered and consumed by metabolically active tissue. As such, …

Key points Haemoglobin affinity is an integral concept in exercise physiology that impacts
oxygen uptake, delivery and consumption. How chronic alterations in haemoglobin affinity …

Impaired tissue oxygen delivery is a major cause of organ damage and failure in critically ill
patients, which can occur even when systemic parameters, including cardiac output and …

Introduction To assess the safety and feasibility of recruiting mechanically ventilated patients
with brain injury who are solely intubated for airway protection and randomising them into …

Background:Non-invasive mechanical ventilation (BiPAP) has been introduced for use in
neuromuscular respiratory disease such as amyotrophic lateral sclerosis and myasthenia …

In the vascular system, an extensive network structure provides convective and diffusive
transport of oxygen to tissue. In the microcirculation, parameters describing network structure, …

The objective of this study is to compare the effectiveness of metabolic signals derived from
erythrocytes and derived from the vessel wall for regulating blood flow in heterogeneous …

The process of pulmonary oxygen uptake is analyzed to obtain an explicit equation for lung
oxygen diffusing capacity in terms of hematocrit and pulmonary capillary diameter. An …