Objective To validate all diagnostic prediction models for ruling out pulmonary embolism that
are easily applicable in primary care. Design Systematic review followed by independent …

Purpose To study whether polypharmacy or drug–drug interactions have differential effect
on safety and efficacy in patients treated with direct oral anticoagulants (DOACs) versus …

Aims Atrial fibrillation (AF) is a common arrhythmia associated with an increased stroke risk.
The use of multivariable prediction models could result in more efficient primary AF …

… Geert-Jan Geersing general practitioner1, Petra MG Erkens clinical epidemiologist2, Wim
AM Lucassen general practitioner3, Harry R Büller professor of medicine4, Hugo ten Cate …

Objective To investigate whether opportunistic screening in primary care increases the detection
of atrial fibrillation compared with usual care. Design Cluster randomised controlled trial…

PURPOSE To validate a smartphone-operated, single-lead electrocardiography (1L-ECG)
device (AliveCor KardiaMobile) with an integrated algorithm for atrial fibrillation (AF) against …

Aims To validate a multivariable risk prediction model (Cohorts for Heart and Aging Research
in Genomic Epidemiology model for atrial fibrillation (CHARGE-AF)) for 5-year risk of atrial …

Aims Premature atrial contractions (PACs) are a common cardiac phenomenon, traditionally
considered to be of little clinical significance. Recent studies, however, suggest that PACs …

Aims Atrial fibrillation (AF) patients have increased risk of stroke. In paroxysmal AF, the
combination of duration and frequency of episodes defines AF burden. In patients with cardiac …

Objective To identify and assess the performance of clinical decision rules (CDR) for chest
pain in general practice. Design Systematic review of diagnostic studies. Data sources …