Background Pain comorbid with depression is frequently encountered in clinical settings
and often leads to significant impaired functioning. Given the complexity of comorbidities, it …

Study objective Increasing opioid prescribing has been linked to an epidemic of opioid
misuse. Our objective is to synthesize the available evidence about patient-, prescriber …

Importance Growing evidence suggests that prescription opioid use affects depression and
anxiety disorders; however, observational studies are subject to confounding, making causal …

Chronic postsurgical pain (CPSP), an often unanticipated result of necessary and even life-
saving procedures, develops in 5–10% of patients one-year after major surgery. Substantial …

Background Many patients having discretionary orthopaedic surgery take opioids daily,
either with a prescription or illicitly, however little is known regarding the prevalence and …

ABSTRACT BACKGROUND Chronic opioid therapy for chronic pain treatment has
increased. Hospital physicians, including hospitalists and medical/surgical resident …

Objectives: Treatment guidelines discourage long-term opioid treatment for patients with
chronic pain and major depression, but this treatment occurs commonly, producing higher …

Background With increased life expectancy for HIV-infected persons, there is concern
regarding comorbid depression because of its common occurrence and association with …

We conducted an analytic review of the clinical scientific literature bearing on the use of
opioids for treatment of chronic non-cancer pain. There is substantial, albeit not definitive …

PURPOSE Recent results suggests the risk of a new onset of depression increases with
longer duration of opioid analgesic use. It is unclear whether new-onset depression related …