Copper and iron are essential but also toxic metals. Their essentiality is known, but their
toxicity, except for the genetic overload diseases, Wilson's disease and hemochromatosis, is …

The significant increase in worldwide morbidity and mortality from non-communicable
diseases (NCDs) indicates that the efficacy of existing strategies addressing this crisis may …

In this review, we point out that natural selection does not act to lessen human diseases after
the reproductive and caregiving period and that normal levels of iron and copper that may …

Background & Aims Risk factors for cardiovascular disease, such as obesity and
hypertension, have been associated with nonalcoholic fatty liver disease. Psychological …

Iron, an essential trace element, plays a complex role in tumour biology. While iron causes
cancer clearance through toxic free radical generation, iron‐induced free radical flux also …

The effects of iron deficiency are well documented, but relatively little is known about the
long-term implications of iron overload during development. High levels of redox-active iron …

Objective: To comprehensively assess iron status and determine whether elevated iron
status, like anemia, predicts mortality. Methods: We followed 1362 Gambian adults (53 …

Objective—Ferritin concentrations are often increased in patients with metabolic syndrome
and type 2 diabetes mellitus, but few reports have examined the associations between …

Background: Dietary supplement use is common in older US adults; however, data on health
risks and benefits are lacking for a number of supplements. Objective: We evaluated …

Excessive or misplaced tissue iron now is recognized to pose a substantial health risk for an
extensive array of endocrinological, gastrointestinal, infectious, neoplasmic …