[PDF][PDF] Randomized trials in primary care: becoming pragmatic

M Marino, J Heintzman - Annals of family medicine, 2022 - Annals Family Med
EDITORIAL characteristic variation between study groups. Most notably, cluster randomized
trials may have substantially reduced statistical efficiency as a result of variance inflation due …

Why most randomized controlled trials are irrelevant: And why yours will not be

A Gupta, C Thorpe, M Zwarenstein - Canadian Family Physician, 2015 - cfp.ca
Conclusion The time has come to critically consider how trials are done and whether the
results can be applied to primary care. As our patients and the health system evolve, our …

Cluster randomized controlled trials in primary care: an introduction

AW Murphy, A Esterman, LS Pilotto - The European journal of …, 2006 - Taylor & Francis
Background: Cluster randomized trials occur when groups or clusters of individuals, rather
than the individuals themselves, are randomized to intervention and control groups and …

The problem of imbalance in cluster randomized trials and the benefits of covariate constrained randomization

LM Dickinson, P Hosokawa, JA Waxmonsky… - Family …, 2021 - academic.oup.com
Cluster randomized trials (CRTs) are particularly important for primary care research, where
pragmatic trials of interventions with shown efficacy are common. Studies may be focused …

Cluster randomization: a trap for the unwary.

M Underwood, A Barnett, S Hajioff - British Journal of General Practice, 1998 - bjgp.org
Controlled trials that randomize by practice can provide robust evidence to inform patient
care. However, compared with randomizing by each individual patient, this approach may …

Lessons for cluster randomized trials in the twenty-first century: a systematic review of trials in primary care

SM Eldridge, D Ashby, GS Feder, AR Rudnicka… - Clinical …, 2004 - journals.sagepub.com
Background Evidence suggests that cluster randomized trials are often poorly designed and
analysed. There is little recent research on the methodologic quality of cluster randomized …

Cluster randomized trials: evaluating treatments applied to groups

WJ Meurer, RJ Lewis - Jama, 2015 - jamanetwork.com
Sometimes a new treatment is best introduced to an entire group of patients rather than to
individual patients. Examples include when the new approach requires procedures be …

Analysis of cluster randomized trials in primary care: a practical approach

MK Campbell, J Mollison, N Steen… - Family …, 2000 - academic.oup.com
Background. Cluster randomized trials increasingly are being used in health services
research and in primary care, yet the majority of these trials do not account appropriately for …

Cluster randomised trials: an important method in primary care research

JF Chenot - Zeitschrift fur Evidenz, Fortbildung und Qualitat im …, 2009 - europepmc.org
In primary care research interventional studies often address organisational changes or
educational interventions, for example, in the context of guideline implementation. For …

Randomised trials in primary care

G Bartlett-Esquilant, M Dickinson… - How To Do Primary …, 2018 - taylorfrancis.com
The randomised control trial (RCT) design arguably is one of the most important
methodological developments in medical research. The RCT evaluates treatments or …