Toward a More Cogent Approach to the Challenges of Multimorbidity

• chronic disease
• comorbidity
• multiple chronic conditions

This issue of the Annals, as well as the previous one, confronts the enormous public health challenges of multimorbidity. More than 1 in 4 Americans has multiple (2 or more) chronic conditions, including physical and behavioral health problems, accounting for an estimated two-thirds of total US health care spending.¹ An individual’s risks for a variety of adverse health outcomes (eg, poor functional status, unnecessary hospitalizations, and adverse drug events) rise as the number of multiple chronic conditions increases.²

The Centers for Medicare and Medicaid Services (CMS) has just released even more detailed information with respect to its Medicare fee-for-service populations,³ exposing the exceptional complexity and sheer burden that multiple chronic conditions pose for patients, health facilities, payers, and clinicians. In its recently released chart book Chronic Conditions Among Medicare Beneficiaries,³ CMS describes detailed demographics and prevalence measures of multiple medical conditions in this population and the dramatic impact on service utilization and spending. Examples of key findings are that two-thirds (20.7 million beneficiaries) had at least 2 or more chronic conditions; about 50% of beneficiaries with stroke or heart failure had 5 or more additional chronic conditions; beneficiaries with 6 or more chronic conditions accounted for about one-half of Medicare spending on hospitalizations; more than one-quarter of beneficiaries with 6 or more chronic conditions had a hospital readmission within 30 days; and the 12% of beneficiaries with 6 or more chronic conditions accounted for 43% of Medicare spending. For health systems that have traditionally focused on research and treatment of single conditions, these tremendous challenges have forced many to escalate efforts to identify and implement solutions.

How do we as a society bring a greater sense of order to this vexing challenge? As part of the response, the US Department of Health and Human Services (HHS), in conjunction with partner organizations and other stakeholders, used a deliberative process to develop Multiple Chronic Conditions—A Strategic Framework: Optimum Health and Quality of Life for Individuals with Multiple Chronic Conditions.² The framework serves as a national-level road map to assist HHS programs and public and private stakeholders in ensuring a more coordinated and comprehensive approach to improving the health status of individuals with multiple chronic conditions.^2,4 Released to stakeholders and the public in late 2010, the framework is organized into 4 major goal areas with subsets of objectives and action strategies for use by clinical practitioners, policy makers, researchers, and others. The framework’s goals encompass the interdependent domains of (1) strengthening the health care and public health systems; (2) empowering the individual to use self-care management; (3) equipping health care clinicians with tools, information, and other interventions; and (4) supporting targeted research about individuals with multiple chronic conditions and effective interventions.

The 3 articles on multimorbidity included in this issue of the Annals,^5–7 which focus on measurement, represent progress in better understanding the epidemiology of multiple chronic conditions, a key aspect of the HHS strategic framework’s fourth goal. The articles further illustrate that there are multiple operational definitions of multimorbidity, each with their respective strengths and weaknesses. Though each may be appropriate according to the outcome of interest, there also may be utility for some degree of standardization in characterizing this heterogeneous population. The definition for multiple chronic conditions used in the HHS strategic framework utilized an approach of simple counts of conditions (ie, 2 or more). The article by Huntley et al, consistent with this approach, finds that simple counts of diseases perform almost as well as complex measures in predicting most outcomes.⁵ Ultimately, however, from a policy perspective, what generally holds true irrespective of the selected measure is that as the magnitude of multimorbidity increases, patient outcomes decline and costs rise. Thus, targeting care management efforts on multimorbid populations should, in principle, accelerate the country’s progress toward the goals of delivery system reform.

We invite readers to further their familiarity with the complex issues posed by multiple chronic conditions by reviewing the HHS strategic framework and related activities (http://www.hhs.gov/ash/initiatives/mcc).⁸ A current HHS collaborative initiative—led by CMS, the Centers for Disease Control and Prevention, and the Agency for Healthcare Research & Quality—is not only examining options for a conceptual framework to improve definition and measurement of priority chronic conditions, but also is conducting coordinated analyses of multiple data sets to improve descriptive epidemiological characterization of multiple chronic conditions. Increasing life expectancy and the aging of the population will only intensify the challenge for the future. The articles in this issue begin to address an enormous health system challenge that demands our urgent attention.

• Received for publication February 3, 2012.
• Accepted for publication February 8, 2012.

• © 2012 Annals of Family Medicine, Inc.