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Research ArticleArticles

Self-Reported PrEP Use and Risk of Bacterial STIs Among Ontarian Men Who Are Gay or Bisexual or Have Sex With Men

Nguyen K. Tran, Seth L. Welles, Jason A. Roy, David J. Brennan, Esther Chernak and Neal D. Goldstein
The Annals of Family Medicine August 2024, 3152; DOI: https://doi.org/10.1370/afm.3152
Nguyen K. Tran
1The PRIDE Study/PRIDEnet, Stanford University School of Medicine, Palo Alto, California
2Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania
PhD, MPH
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Seth L. Welles
2Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania
PhD, ScD
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Jason A. Roy
3Department Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey
PhD
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David J. Brennan
4Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, Canada
PhD
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Esther Chernak
5Department of Environmental and Occupational Health, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania
MD, MPH
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Neal D. Goldstein
2Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania
PhD, MBI
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SUPPLEMENTAL APPENDIX, FIGURES, AND TABLES IN PDF FILE BELOW

  • Tran_Supplemental.pdf -

    Supplemental Appendix. Inverse probability of exposure and attrition weights; Quantitative bias analysis for outcome nondifferential misclassification

    Supplemental Figure 1. Directed acyclic graph for the association of pre-exposure prophylaxis uptake and bacterial sexually transmitted infections (STI) over follow-up in the Diary arm of the iCruise Study, Ontario, Canada, 2017-2018. 

    Supplemental Figure 2. Distribution of nonstabilized and stabilized weights for exposure by pre-exposure prophylaxis uptake over follow-up. The box for each group shows the median (middle horizontal bar) as well as the first and third quartiles (border horizontal bars). Vertical lines extend to observations that are 1.5 × interquartile range.

    Supplemental Figure 3. Distribution of unstabilized and stabilized weights (exposure weights × lost to follow-up weights) summed across all follow-up visits by pre-exposure prophylaxis uptake. The box for each group shows the median (middle horizontal bar) as well as the first and third quartiles (border horizontal bars). Vertical lines extend to observations that are 1.5 × interquartile range. 

    Supplemental Figure 4. Lagged association of PrEP uptake and incidence rate ratio (95% confidence interval) of any bacterial sexually transmitted infections, chlamydia, gonorrhea, and syphilis.

    Supplemental Table 1. Characteristics of gay, bisexual, and other men who have sex with men by study completion in the Diary arm of the iCruise study, Ontario, Canada, 2017-2018 

    Supplemental Table 2. Characteristics of the study population for the LA LGBT Center and iCruise study 

    Supplemental Table 3. Summary of parameters from external literature for quantitative bias analysis of nondifferential outcome misclassification


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