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Research ArticlePoint/Counterpoint

Medication-Assisted Treatment Should Be Part of Every Family Physician’s Practice: No

Richard R. Hill
The Annals of Family Medicine July 2017, 15 (4) 310-312; DOI: https://doi.org/10.1370/afm.2102
Richard R. Hill
1Neighborhood Family Practice, Cleveland, Ohio
2Case Western Reserve University School of Medicine, Department of Psychiatry, Cleveland, Ohio
3Cleveland Clinic Foundation, Department of Psychiatry, Cleveland, Ohio
MD, PhD
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  • For correspondence: rhill@nfpmedcenter.org
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  • Response to Dr. Hill
    Sanketh R Proddutur
    Published on: 12 October 2017
  • Re:Time to Embrace our Role
    Claudia A. Peters
    Published on: 14 August 2017
  • Response to Dr. Coffa's Comments
    Richard R Hill
    Published on: 18 July 2017
  • Time to Embrace our Role
    Diana A Coffa, MD
    Published on: 13 July 2017
  • Published on: (12 October 2017)
    Page navigation anchor for Response to Dr. Hill
    Response to Dr. Hill
    • Sanketh R Proddutur, Faculty Development Fellow

    It is easy to appreciate the experience that Dr. Richard Hill has in treating patients with Substance Use Disorder while reading his perspective on Medication Assisted Treatment (MAT) in the Annals of Family Medicine (1). However, I would beg to differ with his conclusion that primary care physicians would be poor candidates to deliver MAT to this ever-expanding patient population.

    Dr. Hill profiles opioid dep...

    Show More

    It is easy to appreciate the experience that Dr. Richard Hill has in treating patients with Substance Use Disorder while reading his perspective on Medication Assisted Treatment (MAT) in the Annals of Family Medicine (1). However, I would beg to differ with his conclusion that primary care physicians would be poor candidates to deliver MAT to this ever-expanding patient population.

    Dr. Hill profiles opioid dependent patients as "burnt out" on various forms of treatment and too psychiatrically complex to be under the purview of a primary care physician. This impression has admittedly been generated by his experience caring for an urban population (1). However, recent studies have shown that the demographic composition of heroin users entering treatment has shifted to a more widespread geographical distribution (2) presenting more variable patient profiles seeking treatment.

    I agree completely with Dr. Hill that it would be ideal to concurrently manage substance use disorders and psychiatric disorders. However, we do not practice in an ideal setting. Based on 2014 data, the national prevalence of opioid addicted patients was estimated to be 891.8/100000 for people aged 12 years or older while the national rates of maximum potential buprenorphine treatment capacity and patients receiving methadone was respectively, 420.3 and 119.9 (3). This underlines what multiple studies have already concluded (3,4,5), that far more patients are in need of treatment than can currently access it. We also know that opiate addicts in particular are at high risk for mortality during prolonged waiting periods for care (5). A scenario that is easy to visualize if we choose to funnel treatment to specialists that do not have the capacity to currently accommodate this population.

    Simply put, opioid addiction leads to death, to the tune of more than 100 patients per day in the USA (6). Access to MAT can reduce death and increase engagement in care, with some studies suggesting that even interim dosing in the absence of more comprehensive behavioral services proving to be effective, at least in the short term (4). Moving primary care physicians to the front lines would be the most efficient way of expanding access to treatment. This model would also allow for more appropriate referrals for more comprehensive treatment under specialist care for refractory patients.

    Lastly, opioid addiction's heavy burden at least partially arises from the stigma surrounding this disease. Treatment coming from primary care physicians may also have the added benefit of reinforcing this disease as a chronic illness course that needs close regular follow up and reducing societal stigma. I sincerely admire Dr. Hill's experience and dedication in caring for this challenging and underserved patient population. I also recognize that this is the epidemic of our time and accept as my moral obligation a share of the burden in treating this unfortunate disease.

    References
    1. Richard R. Hill MD, PhD. Medication-Assisted Treatment should be part of every family physician's practice: No. Ann Fam Med July/August 2017 vol. 15 no. 4 310-312
    2. Cicero TJ, Ellis MS, Surratt HL, Kurtz SP. The changing face of heroin use in the United States: a retrospective analysis of the past 50 years. JAMA Psychiatry. 2014 Jul 1;71(7):821-6. doi: 10.1001/jamapsychiatry.2014.366.
    3. Jones CM, Campopiano M, Baldwin G, McCance-Katz E. National and State Treatment Need and Capacity for Opioid Agonist Medication-Assisted Treatment. Am J Public Health. 2015 Aug;105(8):e55-63. doi: 10.2105/AJPH.2015.302664. Epub 2015 Jun 11.
    4. Sigmon SC, Ochalek TA, Meyer AC, Hruska B, Heil SH, Badger GJ, Rose G, Brooklyn JR, Schwartz RP, Moore BA, Higgins ST. Interim Buprenorphine vs. Waiting List for Opioid Dependence. N Engl J Med. 2016 Dec 22;375(25):2504-2505. doi: 10.1056/NEJMc1610047
    5. Peles E, Schreiber S, Adelson M. Opiate-dependent patients on a waiting list for methadone maintenance treatment are at high risk for mortality until treatment entry. J Addict Med. 2013 May-Jun;7(3):177-82. doi: 10.1097/ADM.0b013e318287cfc9.
    6. Trump's Opioid Commission Calls for a State of Emergency. Olga Khazan - https://www.theatlantic.com/health/archive/2017/07/government- panel-calls-for-a-state-of-emergency-on-opioids/535485/

    Competing interests: None declared

    Show Less
    Competing Interests: None declared.
  • Published on: (14 August 2017)
    Page navigation anchor for Re:Time to Embrace our Role
    Re:Time to Embrace our Role
    • Claudia A. Peters, Family Physician

    I find the opinions of specialists who have not worked with Family Physicians are based on attitudes rather than experience. Family Physicians are most capable of managing addictions. They can manage the medical and psychiatric co-morbidities of addicts. We are specialists in listening, being accessible and managing multiple chronic conditions. Our training involves knowledge and use of community services. I have chosen...

    Show More

    I find the opinions of specialists who have not worked with Family Physicians are based on attitudes rather than experience. Family Physicians are most capable of managing addictions. They can manage the medical and psychiatric co-morbidities of addicts. We are specialists in listening, being accessible and managing multiple chronic conditions. Our training involves knowledge and use of community services. I have chosen recently to work full time in a rural psychiatric facility. I am a physician prescriber for the clinic, am a resource for the mobile crisis team, am a co-provider for the inpatient unit, and am a prescriber for the substance abuse therapy groups. I am referred most of the psychiatric patients who also have serious medical illnesses, including brain injury or illness. I have psychiatrists easily available for consultation which has been blessedly true for most of my career. I have received many compliments from staff that it is convenient to have my medical expertise on site. The training for buprenorphine prescribing is similar to other medical pharmacology. A little support from peer counselors, psychiatry and social workers has oriented me quickly to the world of addicts and I have been very comfortable in my setting. My Suboxone patients are appreciative the stability that this medications brings to their broken lives.

    Competing interests: None declared

    Show Less
    Competing Interests: None declared.
  • Published on: (18 July 2017)
    Page navigation anchor for Response to Dr. Coffa's Comments
    Response to Dr. Coffa's Comments
    • Richard R Hill, psychiatrist

    In my experience, patients who seek buprenorphine treatment/are most appropriate patients for buprenorphine for their opiate use have a more severe stage of disease.

    Using the DSM-5 criteria for Substance Use Disorder (SUD), patients may be separated into "mild, moderate or severe" depending on how many criteria are met. For example, someone with mild SUD might occasionally use a low dose of a low potency opioid...

    Show More

    In my experience, patients who seek buprenorphine treatment/are most appropriate patients for buprenorphine for their opiate use have a more severe stage of disease.

    Using the DSM-5 criteria for Substance Use Disorder (SUD), patients may be separated into "mild, moderate or severe" depending on how many criteria are met. For example, someone with mild SUD might occasionally use a low dose of a low potency opioid, and might have received it initially from a provider for an acute pain indication. Such patients are employed, maintain a job and relationships and in general have few if any other psychosocial issues. Moderate SUD patients take higher potency opioids on a more regular/daily basis, might have withdrawal if they run out and have likely lost a job or two and have lost relationships from their use as well. Patients with severe disease use opioids throughout the day, often multiple times-to avoid severe withdrawal symptoms. They spend their time procuring the drug, have lost relationships/jobs, and steal, often from their own family, to support their habit. Their preferred route of administration has switched from oral to intranasal or IV and they have often experienced other negative health consequences from their use. So, the treatment plan we recommend is based on the stage of the disease, as well as the patient's unique mental health and physical history/condition and patient preference -but we certainly would not recommend buprenorphine as initial treatment to a patient with mild substance use disorder. Many times, counseling, frequent visits/urine testing, support from family/friends and if desired, AA/NA is enough to get mild stage disease patients back on track. Naltrexone/vivitrol may be indicated as well in some cases. So I disagree with Dr. Coffa's statement, "buprenorphine, methadone, and naltrexone should all be offered as choices for patients when they initially present to care". Rather, it is our duty as treatment specialists, to properly assess the level of disease and then to suggest a treatment plan tailored to meet the patient's unique needs and level of illness. This approach coincides more with Dr. Coffa's earlier view presented in the Am Fam Physician, 2013 Jul 15;88(2);113-121 article where she essentially stratifies patients into 3 categories of severity, each calling for a different level of intervention, (using DSM IV TR criteria). In this article, Dr. Coffa states, "After a positive screening, a brief assessment should be performed to stratify patients into three categories: hazardous use, substance abuse, or substance dependence. Patients with hazardous use benefit from brief counseling by a physician. For patients with substance abuse, brief counseling is also indicated, with the addition of more intensive ongoing follow-up and reevaluation. In patients with substance dependence, best practices include a combination of counseling, referral to specialty treatment, and pharmacotherapy (e.g., drug tapering, naltrexone, buprenorphine, methadone)".

    I would also like to address Dr. Coffa's statement, "it would be medically inappropriate to require that people try and fail therapies that typically do not work before they are given access to [buprenorphine]". I couldn't agree more. Perhaps my statement was misunderstood. What I stated is the following; "Patients requiring B/BN have exhausted/failed all other forms of treatment intervention including abstinence efforts and AA/NA/sponsors, other non-agonist pharmacotherapies, addiction counseling, intensive outpatient treatment, partial hospitalization, residential programs and other forms of rehabilitation, perhaps even court-ordered treatment with mandatory accountability and urine tox-screen assessments". Not that we require them to have failed the interventions before being offered MAT but rather that most have already been through these treatments by the time they arrive at our door. Again in my experience (5 years as staff psychiatrist at large urban FQHC), most patients who end up on agonist therapy have already been through many of the above treatments and so are likely to have a moderate to severe substance use disorder. It is possible that folks at more rural or more socioeconomically advantaged areas might present with moderate disease without having progressed through multiple other treatments, but this has not been our experience.

    Dr. Coffa comments, "Dr Hill also argues that people with substance use disorder have too much co-morbid psychiatric illness to fit into the family medicine scope of practice". Again, perhaps some clarification will help. Since we see patients who have more severe stages of opiate use disorders, they often will have more severe co-morbid psychiatric illness (see references from original article). Psychiatry at our FQHC is integrated and co-located. Providers often refer their patients with more severe mental health issues to see psychiatry-and so they are likely to feel the same or greater need to refer to psychiatry when such patients are afflicted with a co-occurring opiate use disorder as well. Much depends on where you are treating patients-inner city, urban centers will be populated with more severe illness and will require more specialist care while suburban/rural centers may see more mild illness that can be handled by PCP's alone.

    For 18 years before transitioning to an FQHC, I served as medical director for an urban community mental health center where dual diagnosis (substance use and mental illness) was the focus. I worked closely with others at the agency and with the local mental health board to develop a Suboxone clinic for our patients-one that ran for several years until funding issues impacted our ability to continue our clinic. The patients in this clinic were a fairly severely ill population, and as I reflect back on the effort, this clinic, while comprised of only 30 or so patients, required significantly more support staff/CPST help and doctor time than any of us would have anticipated at the outset. This experience, in part, compelled me to share a counterpoint view when considering the impact such intensive care might have on our already overburdened primary care workforce.

    That said, there are no doubt many medical centers with providers that will be able to effectively handle mild to moderate opiate use disorders using MAT/other interventions, but I fear that in more urban centers where the disease burden is highest, the best-intentioned PCP's, even those trained to handle more routine mental health problems such as Dr. Coffa's residents, may find their already over-filled schedules, increasingly complex case-loads and brief appointment times made even more difficult to negotiate when even a few of the more severely ill dual diagnosis patients are added to their caseload.

    Dr. Coffa states, "It is time to Embrace our Role", stating that "substance use disorder treatment is a natural extension of our scope". It has been my experience that primary care providers always have the best interests of their patients at heart, and work tirelessly to meet their needs. But if primary care is too willing to "embrace" the opiate crisis with open arms, they may find that they have taken on more than they can accommodate with current staffing levels. Such an awareness might fuel efforts to pursue increased financial resources from the government to support the increased work. Such resources are needed to support increases in staffing, programming and specialty services that will be necessary to properly address the complexity of this disease.

    Competing interests: None declared

    Show Less
    Competing Interests: None declared.
  • Published on: (13 July 2017)
    Page navigation anchor for Time to Embrace our Role
    Time to Embrace our Role
    • Diana A Coffa, MD, Director

    I was delighted to see that the current issue of the Annals focused on the management of substance use disorders in the primary care setting. As family physicians, we have extensive training in managing complex, socially determined chronic illnesses like diabetes and hypertension, and substance use disorder treatment is a natural extension of our scope. We are also well trained in psychosocial medicine and should be equi...

    Show More

    I was delighted to see that the current issue of the Annals focused on the management of substance use disorders in the primary care setting. As family physicians, we have extensive training in managing complex, socially determined chronic illnesses like diabetes and hypertension, and substance use disorder treatment is a natural extension of our scope. We are also well trained in psychosocial medicine and should be equipped to provide the family centered, psychosocially oriented care that people with substance use disorder require.

    I was therefore disappointed to see Dr. Hill speak out against making MAT a standard part of family physician practice. I was very surprised by his reasoning. He argues that people who are candidates for buprenorphine must have failed AA/NA, behavioral treatments, and non-agonist therapy, and therefore represent severe stages of disease. This is patently untrue. Buprenorphine is a first line therapy for opioid use disorder. Because abstinence based therapies have extremely high relapse rates, the American Society of Addiction Medicine, the Substance Abuse and Mental Health Services, and many other professional organizations all recommend MAT as first line therapy for opioid use disorder (OUD). Non-agonist medications have very high drop out rates in studies and are therefore not superior to buprenorphine. Nor are they necessarily inferior, depending on the patient's goals, values, and risk factors. Buprenorphine, methadone, and naltrexone should all be offered as choices for patients when they initially present to care.

    MAT is appropriate for people who have not tried NA or AA, and who have not participated in outpatient or residential rehabilitation programs. It would be medically inappropriate to require that people try and fail therapies that typically do not work before they are given access to a therapy that clearly saves lives, rebuilds careers, and reconstitutes families.

    This basic misunderstanding of the role of MAT is dangerous to perpetuate. If family physicians believe that people are not candidates for MAT until they have completed and failed residential treatment, NA, or any number of other therapies, it means we are failing to treat this population. It suggests that we are recommending ineffective therapies and withholding effective ones. This understanding may be born of a misunderstanding about the effects of buprenorphine on peoples' lives. Rather than locking people into an addiction, which is how some people imagine buprenorphine works, it genuinely sets people free. It sets them free to focus on their lives, their relationships, their work, their personal development, and their communities. With time, some stabilize to the point that they choose to taper off of buprenorphine. Others remain on it, much like patients on antidepressants. Like antidepressants, the choice about when to start the medication must be patient centered and unique, but also informed by evidence. We would not require that patients fail a course of CBT before starting an SSRI.

    Dr. Hill also argues that people with substance use disorder have too much co-morbid psychiatric illness to fit into the family medicine scope of practice. Again, I find this line of argument confusing. As a residency program director, I train my residents to manage a variety of mental health conditions and, while they may need to reach out for help with complex cases, I consider this well within their scope.

    As Dr. Hill alludes to, a number of studies to date have shown that buprenorphine in primary care is effective, and some have shown that buprenorphine is actually more effective when provided in the primary care setting than in the specialty setting (1). This may be because of the longitudinal relationships we form in primary care, our contextual orientation, our ability to keep the patient engaged in care by working with them on other medical issues, or our ability to engage the family effectively. Whatever the reason, we are empirically capable of providing this care and I do not think we should sell ourselves short by pretending that it is beyond us.

    Whether we are providing buprenorphine or not, our practices are full of people who need help with OUD. My own residents all complete buprenorphine certification training during residency because we know that this will be a critical service for years to come. It is time for us to embrace our role and respond to this crisis.

    1) O'Connor P, Oliveto A, Shi J, Triffleman E, Carroll K, Kosten T, Rounsaville B, Pakes J, Schottenfeld R. A andomized Trial of Buprenorphine Maintenance for Heroin Dependence in a Primary Care Clinic for Substance Users versus a Methadone Clinic. The American Journal of Medicine, August 1998, vol 105(100-105)

    Competing interests: None declared

    Show Less
    Competing Interests: None declared.
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The Annals of Family Medicine: 15 (4)
The Annals of Family Medicine: 15 (4)
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Medication-Assisted Treatment Should Be Part of Every Family Physician’s Practice: No
Richard R. Hill
The Annals of Family Medicine Jul 2017, 15 (4) 310-312; DOI: 10.1370/afm.2102

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Medication-Assisted Treatment Should Be Part of Every Family Physician’s Practice: No
Richard R. Hill
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  • Is Prediabetes Overdiagnosed? Yes: A Patient-Epidemiologist’s Experience
  • Medication-Assisted Treatment Should Be Part of Every Family Physician’s Practice: Yes
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