Article Figures & Data
Figures
- Figure 1.
Forest plot of lung cancer incidence for trials with 8 or more years of follow-up.
DANTE = Detection and Screening of Early Lung Cancer With Novel Imaging Technology; DLCST = Danish Lung Cancer Screening Trial; ITALUNG = Italian Lung Cancer Screening Trial; LUSI = Lung Cancer Screening Intervention; NELSON = Nederlands–Leuvens Longkanker Screenings Onderzoek; RR = relative risk.
Note: Weights are from random effects analysis.
- Figure 2.
Forest plot of lung cancer–specific mortality, sorted by shortest to longest median duration of follow-up.
DANTE = Detection and Screening of Early Lung Cancer With Novel Imaging Technology; DLCST = Danish Lung Cancer Screening Trial; ITALUNG = Italian Lung Cancer Screening Trial; LSS = Lung Screening Study; LUSI = Lung Cancer Screening Intervention; MILD = Multicentric Italian Lung Detection; NELSON = Nederlands–Leuvens Longkanker Screenings Onderzoek; RR = relative risk.
Note: Weights are from random effects analysis.
- Figure 3.
Forest plot of all-cause mortality, sorted by shortest to longest median duration of follow-up.
DANTE = Detection and Screening of Early Lung Cancer With Novel Imaging Technology; DLCST = Danish Lung Cancer Screening Trial; ITALUNG = Italian Lung Cancer Screening Trial; LSS = Lung Screening Study; LUSI = Lung Cancer Screening Intervention; MILD = Multicentric Italian Lung Detection; NELSON = Nederlands–Leuvens Longkanker Screenings Onderzoek; RR = relative risk.
Note: Weights are from random effects analysis.
Tables
Trial, Year Random Sequence Generation Allocation Concealment Blinding of Participants and Personnel Blinding of Outcome Assessmenta Incomplete Outcome Data Selective Reporting National Lung Screening Trial Research Team et al,5 2011 L L L L/U L L Infante et al,7 2015 L U L L/U L L Wille et al,8 2016 L L L L/U L L Paci et al,19 2017 L L L L/U L L Yang et al,12 2018 H H L L/U L L Doroudi et al,20 20 1 8 L U L L/U L L Pastorino et al,21 2019 L L L L/U L L Becker et al,18 2020 L U L L/U L L de Koning et al," 2020 L U L L/U L L H = high risk of bias; L = low risk of bias; U = unclear risk of bias.
↵a Risk of bias for all-cause mortality/risk of bias for lung cancer-specific mortality.
Note: Quality was assessed with the Cochrane Risk of Bias Tool.15
Trial, Year Inclusion Criteria Participants,No. Lung Cancer Mortality in Control Group, % Age at Study Entry Sex, % Male Median Follow-up, Y Pack-Years of Smoking at Entry Current Smokers, % Country Screening Years National Lung Screening Trial Research Team et al,5 2011 Aged 55-74 years, ≥30 pack-years, current smoker or quit within last 15 years 53,454 1.7 NR 59.0 6.5 Median: 48 48 United States 2002-2007 Infante et al,7 2015 Aged 60-74 years, male, smoker of ≥20 pack-years or quit within 10 years 2,450 4.6 Mean: 64.6 years 100.0 8.35 Median: 45; mean: 47 57 Italy 2001-2012 Wille et al,8 2016 Aged 50-70 years, smoker of ≥20 pack-years or exsmoker who had quit after aged 50 years, and within 10 years 4,104 1.9 Mean: 57.9 years 55.2 9.8 Mean: 36 76 Denmark 2004-2008 Paci et al,19 2017 Aged 55-69 years, smoker or exsmoker (≥20 pack-years in the last 10 years) who had quit no more than 10 years ago 3,206 3.8 Mean: 60.8 years 64.7 8.5 Median: control, 38; screening, 40 66 Italy 2004-2014 Doroudi et al,20 2018 Aged 55-74 years, smoker of ≥30 pack-years or quit within last 10 years 3,318 1.6 NR 58.6 5.2 Median: 54 58 United States 2000-2001 Pastorino et al,21 2019 Aged 49-75 years, current smoker ≥20 pack-years or quit within last 10 years, no cancer in last 5 years 4,099 2.3 Median: control, 57 years; screening, 58 years 66.3 6.2 Median: control, 38; screening, 39 Control: 90 screening: 69 Italy 2005-2018 Becker et al,18 2020 Aged 50-69 years, ≥25 years of smoking 15 cigarettes per day, or ≥30 years of smoking 10 cigarettes per day, or exsmoker who quit no more than 10 years ago 4,052 2.0 NR 64.7 8.9 NR 62 Germany 2011-2018 de Koning et al,11 2020 Aged 50-74 years, male, current or former smoker (who had quit within 10 years) who smoked >15 cigarettes per day for >25 years or who smoked >10 cigarettes per day for >30 years 15,789 3.1 Median: 58 years 83.6 10.0 Median: 38 55 Netherlands and Belgium 2003-2015 NR = not reported.
Supplemental Appendix & Table
Supplemental Appendix & Table
Files in this Data Supplement:
- Supplemental data: Appendix, Table, Figs - PDF file
Correction
In the originally published article, the x-axis was labeled incorrectly and the scale was incorrect. The author regrets the error. The figure has been corrected online; therefore, the online figure differs from the print publication.
