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Research ArticleOriginal Research

Syndromic Surveillance for Emerging Infections in Office Practice Using Billing Data

Philip D. Sloane, Jennifer K. MacFarquhar, Emily Sickbert-Bennett, C. Madeline Mitchell, Roger Akers, David J. Weber and Kevin Howard
The Annals of Family Medicine July 2006, 4 (4) 351-358; DOI: https://doi.org/10.1370/afm.547
Philip D. Sloane
MD, MPH
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Jennifer K. MacFarquhar
RN, BSN, CIC
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Emily Sickbert-Bennett
MS
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C. Madeline Mitchell
MURP
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Roger Akers
MS
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David J. Weber
MD, MPH
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Kevin Howard
MD
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    Figure 1.
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    Figure 1.

    Daily number of respiratory syndrome codes reported by Dayspring Family Medicine and by emergency departments in the 6 surrounding counties, 15 November 2003 through 15 January 2004.

    Note: Circles represent days when the surveillance threshold of 2 SD was exceeded.

  • Figure 2.
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    Figure 2.

    Flow chart of proposed primary-care–based syndromic surveillance system.

    ICD-9 = International Classification of Diseases, Ninth Revision.

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    Table 1.

    CDC Syndrome Codes and Definitions

    SyndromeDefinitionICD-9 codes
    CDC = Centers for Disease Control and Prevention; ICD-9 = International Classification of Diseases, Ninth Revision.
    Note: CDC Web link with syndrome definitions: http://www.bt.cdc.gov/surveillance/syndromedef/index.asp.
    Botulism-likeParalytic conditions consistent with botulism; or other symptoms consistent with botulism: diplopia, dry mouth, dysphagia, difficulty focusing to a near point005.1, 344.04, 344.09,344.2, 344.89,344.9, 351.9,352.6, 352.9,357.0, 368.2,374.30, 378.51,378.52, 378.53,378.54, 378.55
    Hemorrhagic illnessSpecific diagnosis of any virus that causes viral hemorrhagic fever (VHF), such as yellow fever, Lassa, or Ebola; or any acute condition with multiple organ involvement or acute blood abnormalities that may be consistent with exposure to a virus that causes VHF287.1, 287.2, 287.8, 287.9, 511.8, 790.01, 790.92
    LymphadenitisAcute regional lymph node swelling and/or infection (painful bubo), particularly in groin, axilla, or neck020.0, 021.0, 021.3, 075, 289.3, 683, 785.6
    Localized cutaneous lesionCutaneous lesion, ulcer, or localized edema consistent with cutaneous anthrax or tularemia.020.0, 020.1, 021.0, 022.0, 680.0, 680.1, 680.2, 680.3, 680.4, 680.5, 680.6, 680.7, 680.8, 707.11, 707.12, 707.13, 707.14, 707.19
    GastrointestinalAcute upper and/or lower gastrointestinal (GI) tract infection; or acute nonspecific symptoms of GI distress such as nausea, vomiting, or diarrhea005.89, 005.9, 008.49, 008.5, 008.69, 008.8, 009.0, 009.1, 009.2, 009.3, 022.2, 078.82, 535.00, 535.01, 535.40, 535.41, 535.50, 535.51, 535.60, 535.61, 536.2, 555.0, 555.1, 555.2, 558.2, 558.9, 569.9, 787.01, 787.02, 787.03, 787.3, 787.91
    RespiratorySpecific diagnosis of any acute infection of the upper and/or lower respiratory tract; or acute nonspecific diagnosis or symptoms of respiratory tract infection020.3, 020.4, 020.5, 021.2, 022.1, 460, 462, 463, 464.00, 464.01, 464.10, 464.11, 464.20, 464.21, 464.30, 464.31, 464.4, 464.50, 464.51, 465.0, 465.8, 465.9, 466.0, 466.11, 466.19, 478.9, 480.8, 480.9, 482.9, 483.8, 484.5, 484.8, 485, 486, 490, 511.0, 511.1, 511.8, 513.0, 513.1, 518.4, 518.84, 519.2, 519.3, 769, 786.00, 786.06, 786.1, 786.2, 786.3, 786.52, 799.1
    NeurologicalAcute infection of the central nervous system (CNS) with a specific diagnosis, such as pneumococcal meningitis; or acute nonspecific symptoms of CNS infection047.8, 047.9, 048, 049.0, 049.9, 320.9, 321.2, 322.0, 322.1, 322.9, 323.8, 323.9, 348.3, 781.6
    RashAcute condition having signs or symptoms consistent with smallpox; specific diagnosis of acute infectious rash (eg, chicken pox); or nonspecific infectious rash. Excludes noninfectious skin rashes, such as eczema, seborrheic dermatitis, and contact dermatitis050.0, 050.1, 050.2, 050.9, 051.0, 051.1, 052.7, 052.8, 052.9, 057.8, 057.9, 695.0, 695.1, 695.2, 695.89, 695.9
    FeverAcute febrile illness of unspecified origin020.2, 020.8, 020.9, 021.8, 021.9, 022.3, 022.8, 022.9, 038.3, 038.40, 038.49, 038.8, 038.9, 079.89, 079.99, 780.31, 780.6, 790.7, 790.8,
    Severe illness or death potentially due to infectious diseaseAcute onset of shock or coma from potentially infectious causes780.01, 785.50, 785.59, 798.1, 798.2, 798.9, 799.9
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    Table 2.

    Daily Frequency of Syndrome Codes in 1 Family Medicine Practice for 1 Calendar Year (n = 239 days)*

    SyndromeMean (SD)Range
    * Weekend days and holidays omitted.
    Botulism-like0.0 (0.0)0
    Hemorrhagic illness0.01 (0.09)0–1
    Lymphadenitis0.63 (0.97)0–5
    Localized cutaneous lesion0.03 (0.17)0–1
    Gastrointestinal4.05 (2.97)0–14
    Respiratory26.73 (15.91)2–92
    Neurological0.03 (0.23)0–3
    Rash0.38 (0.74)0–4
    Fever1.75 (1.89)0–10
    Severe illness or death0.0 (0.0)0
    Number of codes recorded per day252.55 (59.36)56–394
    • View popup
    Table 3.

    Frequency and Distribution of Significant Aberrations (Signals) by Threshold Level and Site

    Percentage of Days With Significant Aberrations* in the Number of Observed Cases, by Syndrome
    Threshold for Dayspring ClinicThreshold for Emergency Department, UNC Hospitals
    Syndrome2 SD3 SD2 SD3 SD
    ICD-9 = International Classification of Diseases, Ninth Revision.
    * A significant aberration (signal) occurs when the number of cases recorded for that day exceeds the statistically determined threshold, based on observed cases from the previous week.
    Botulism-like0012.66.2
    Hemorrhagic illness0.90.913.26.2
    Lymphadenitis11.35.67.63.7
    Cutaneous lesion3.02.69.05.6
    Gastrointestinal6.13.58.72.8
    Respiratory6.92.29.01.7
    Neurological2.22.211.85.9
    Rash11.37.410.75.1
    Fever11.35.67.63.9
    Severe illness/death008.75.3
    Any of the above syndromes40.024.363.536.5
    Average ICD-9 codes per day244641

Additional Files

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  • The Article in Brief

    Syndromic Surveillance for Emerging Infections in Office Practice Using Billing Data

    Philip D. Sloane, MD, MPH, and colleagues

    Background Syndromic surveillance is the monitoring of health data to identify possible outbreaks of diseases associated with bioterrorism or pandemic illness. Since patients often visit their primary care doctors when they first become sick, primary care practices could provide timely information, yet there has been little research on syndromic surveillance in primary care settings. This study tested whether it is practical to conduct syndromic surveillance in a primary care office using billing data.

    What This Study Found This 1-year study of a primary care practice finds that it is practical to convert billing data into daily summaries of diagnosis codes, which can be used for rapid surveillance of disease patterns in a community. These systems can be easily implemented at a low cost and with minimal effort.

    Implications

    • Further development of syndromic surveillance systems should include primary care offices.
    • This type of surveillance could be used to detect bioterrorism attacks and emerging infections, especially those that are not lethal and resemble common infections.
    • Rapid conversion of primary care practices to electronic medical records opens up the possibility of new, potentially low-cost systems for early detection of emerging infectious diseases.
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The Annals of Family Medicine: 4 (4)
The Annals of Family Medicine: 4 (4)
Vol. 4, Issue 4
1 Jul 2006
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Syndromic Surveillance for Emerging Infections in Office Practice Using Billing Data
Philip D. Sloane, Jennifer K. MacFarquhar, Emily Sickbert-Bennett, C. Madeline Mitchell, Roger Akers, David J. Weber, Kevin Howard
The Annals of Family Medicine Jul 2006, 4 (4) 351-358; DOI: 10.1370/afm.547

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Syndromic Surveillance for Emerging Infections in Office Practice Using Billing Data
Philip D. Sloane, Jennifer K. MacFarquhar, Emily Sickbert-Bennett, C. Madeline Mitchell, Roger Akers, David J. Weber, Kevin Howard
The Annals of Family Medicine Jul 2006, 4 (4) 351-358; DOI: 10.1370/afm.547
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