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Research ArticleOriginal Research

Association Between Third-Generation Fluoroquinolones and Achilles Tendon Rupture: A Self-Controlled Case Series Analysis

Takashi Chinen, Yusuke Sasabuchi, Hiroki Matsui and Hideo Yasunaga
The Annals of Family Medicine May 2021, 19 (3) 212-216; DOI: https://doi.org/10.1370/afm.2673
Takashi Chinen
1Department of Clinical Oncology, Jichi Medical University, Tochigi, Japan
2Data Science Center, Jichi Medical University, Tochigi, Japan
MD
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  • For correspondence: m02061tc@jichi.ac.jp
Yusuke Sasabuchi
2Data Science Center, Jichi Medical University, Tochigi, Japan
MD, MPH, PhD
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Hiroki Matsui
2Data Science Center, Jichi Medical University, Tochigi, Japan
3Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan
MPH
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Hideo Yasunaga
2Data Science Center, Jichi Medical University, Tochigi, Japan
3Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan
MD, PhD
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Table 2.

Table 2.

Characteristics of Study Patients (N = 504)

CharacteristicValue
Age, median (IQR), y64 (48-74)
Age-group, No. (%)
 <20 years28 (6)
 20-60 years170 (34)
 >60 years306 (61)
Sex, No. (%)
  Male299 (59)
  Female205 (41)
  • IQR = interquartile range.

  • Notes: Characteristics were as recorded at the start of the observation period.

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The Annals of Family Medicine: 23 (3)
The Annals of Family Medicine: 23 (3)
Vol. 23, Issue 3
May/June 2025
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Association Between Third-Generation Fluoroquinolones and Achilles Tendon Rupture: A Self-Controlled Case Series Analysis
Takashi Chinen, Yusuke Sasabuchi, Hiroki Matsui, Hideo Yasunaga
The Annals of Family Medicine May 2021, 19 (3) 212-216; DOI: 10.1370/afm.2673

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Association Between Third-Generation Fluoroquinolones and Achilles Tendon Rupture: A Self-Controlled Case Series Analysis
Takashi Chinen, Yusuke Sasabuchi, Hiroki Matsui, Hideo Yasunaga
The Annals of Family Medicine May 2021, 19 (3) 212-216; DOI: 10.1370/afm.2673
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Subjects

  • Methods:
    • Quantitative methods
  • Other research types:
    • Professional practice

Keywords

  • fluoroquinolone
  • antibiotics
  • adverse effects
  • Achilles tendon rupture
  • tendon injuries
  • self-controlled case series
  • precision medicine

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