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Research ArticleOriginal Research

Treatment of Ingrown Toenail With Proximolateral Matrix Partial Excision and Matrix Phenolization

Nezih Karaca and Tugrul Dereli
The Annals of Family Medicine November 2012, 10 (6) 556-559; DOI: https://doi.org/10.1370/afm.1406
Nezih Karaca
1Department of Dermatology, Okmeydani Education and Research Hospital, Okmeydani, Sisli, Istanbul, Turkey
MD
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  • For correspondence: drnezihkaraca@gmail.com
Tugrul Dereli
2Department of Dermatology, Ege University Medical Faculty, Bornova, Izmir, Turkey
MD, Prof
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Abstract

PURPOSE Ingrown toenail is one of the most common nail conditions. Although many surgical treatments are described for complicated cases, recurrence of pain and postoperative disability are common. We evaluated the long-term efficacy of proximolateral matrix partial excision followed by chemical matricectomy with phenol.

METHODS We performed 348 proximolateral partial matricectomies and phenol ablations in 225 patients with stage 2 or 3 ingrown toenail. Patients were examined weekly until full wound healing was achieved and were observed for 24 months to assess the long-term efficacy of the treatment.

RESULTS Short-term results were good. We observed only 1 recurrence during the 24-month follow-up period, at 8 months. The success rate was therefore 99.7%. No severe complications occurred. Cosmetic results were remarkably good.

CONCLUSIONS Proximolateral partial matricectomy with phenol ablation is an excellent surgical method for the treatment of ingrown toenails, having low morbidity and a high success rate, even in the long term.

Key words
  • ingrown toenail
  • onychocryptosis
  • unguis incarnatus
  • surgery
  • phenol
  • matricectomy

INTRODUCTION

Ingrown toenails caused by compression of the lateral nail edge on the underlying soft tissue is one of the most common nail problems, accounting for 20% of patients seen by family physicians for foot conditions.1 Adolescents and young adults are affected more frequently than other age-groups. Ingrown toenail most often occurs on the big toe, although it can occur on other digits.2 An ingrown toenail develops when the proper fit of the nail plate in the lateral nail groove is altered, and several causes (anatomic abnormalities, improperly trimmed nails, poorly fitting shoes, and repetitive trauma) have been suggested. The condition causes discomfort and pain, and restricts activity.3,4

A staging system has been developed to grade the severity of ingrown toenails.2,5 Stage 1 is characterized by erythema, slight edema, and pain, particularly with pressure. Stage 2 consists of the same symptoms but of greater severity; the wound may become locally infected and start to drain. In stage 3, all signs and symptoms are amplified, and there is associated formation of granulation tissue and lateral nail fold hypertrophy.

Various methods of treating ingrown toenails have been described, ranging from conservative approaches to extensive surgical procedures.6-8 The combination of proximolateral partial matricectomy and phenol ablation achieves the lowest recurrence rate and provides the best cosmetic outcome. To the best of our knowledge, this is the first study to assess this technique when performed using a modified version of the Zadik method for matricectomy. We chose this technique as it is more invasive than simple partial nail avulsion and easier to perform than wide wedge excision. Also, excising the lateral and proximolateral matrices, in addition to avulsing the nail, and then applying phenol may further reduce the recurrence rate.

METHODS

Between 2006 and 2010, we performed proximolateral partial matricectomy and phenol ablation in a series of patients with stage 2 or 3 ingrown toenails. Patients with vascular disease and diabetes mellitus were excluded. Our study was approved by the Ege University Hospital Ethics Committee and complied with the principles of the Declaration of Helsinki.

Surgical Technique

After disinfection of the digits with povidone-iodine solution, we administered digital anesthesia consisting of lidocaine hydrochloride 20 mg/mL and epinephrine hydrochloride 0.0125 mg/mL (Supplemental Figure 1, available at http://annfammed.org/content/10/6/556/suppl/DC1). A finger tourniquet was applied to the digit and clamped. We made a longitudinal incision roughly 7 to 8 mm extending from the edge of the nail to the distal interphalangeal joint and 3 mm proximal to the lateral nail fold, but did not raise skin flaps. After dissecting the lateral segment (3 mm) of the plate from the nail bed to the matrix, we cut the nail plate and proximolateral matrix using a side cutter. We removed the nail and matrix using a straight hemostatic forceps (Klemmer or Kelly) and ensured that all matrices over the distal phalanx were cleaned using a curette (Supplemental Figure 2, available at http://annfammed.org/content/10/6/556/suppl/DC1). We cleaned blood from the surgical field thoroughly using a cotton-tipped swab and then vigorously massaged the matrix for 2 minutes with a cotton-tipped swab dipped in an aqueous solution of 88% phenol, with rotation directed toward the lateral fold (Supplemental Figure 3, http://annfammed.org/content/10/6/556/suppl/DC1). Contact of phenol with the surrounding skin was avoided, and the treated area was carefully washed with 70% isopropyl alcohol to neutralize any residual phenol. In this way, both the matrix and nail bed on the side of ingrown toenail were excised, and any matrix residues were denatured with phenol.

The wound was closed with one suture 3 mm under the proximal nail curve and another through the middle of the lateral nail plate. We applied topical antibiotics, and after tourniquet removal, a pressure dressing with a sterile gauze pad that was left in place for 24 hours.

Postoperative Care

After surgery, patients were given oral nonsteroidal anti-inflammatory drugs for pain control. Older adults were also prescribed oral azithromycin 500 mg/d for 3 days. Patients were advised to keep the affected foot elevated whenever possible and were taught how to change the dressing and instructed to do so once daily, from the third postoperative day until full wound healing. Any infections of the nail fold were treated using topical antibiotics. Clinical follow-up was performed at 2, 4, 8, and 16 weeks, and telephonic follow-up was performed at 1 and 2 years. Recurrence was defined as evidence of ingrowth of the nail edge or spicule formation.

RESULTS

In all, we treated 348 ingrown toenails in 225 patients (98 male and 127 female) (Table 1). The mean age of the patients was 23.8 ± 8.2 years. All patients had been previously treated using conservative methods, and 56 had previously been treated with nail avulsion.

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Table 1.

Patient Characteristics (N = 225)

We did not record any postoperative complications or complaints about the cosmetic outcome. The healing period ranged from 2 to 4 weeks (Supplemental Figures 4a and 4b, available at http://annfammed.org/content/10/6/556/suppl/DC1).

There was only 1 recurrence of ingrown toenail, observed 8 months after treatment. This patient underwent reoperation using the same technique and did not have any further recurrence during 2 years of follow-up. The success rate after 2 years was thus 99.7%. Telephonic follow-up at 2 years showed that all the patients were satisfied with the cosmetic outcome.

DISCUSSION

Our results show that partial nail plate avulsion combined with excision of the lateral and proximal nail matrix and followed by phenolic ablation is a suitable surgical method for treating severe ingrown toenails, and is associated with a low recurrence rate and excellent cosmetic results.

Phenolization

Segmental matrix cauterization with liquefied phenol has been shown to permanently destroy the lateral matrix. Phenol (C6H5OH) is a colorless crystal derived from coal tar. Liquefied phenol (carbolic acid) has antibacterial, anesthetic, and, in its concentrated form, escharotic properties. It acts via denaturation of the matrix and any other soft tissue proteins.7

The aim of phenol therapy is chemical destruction of the lateral and proximal horns of the matrix, and prevention of future growth of the lateral nail plate into the proximolateral nail fold. The main contraindications for chemical matricectomy are moderate to severe vascular disease of the foot, factors delaying wound healing, and allergy to the chemical used.8,9

Surgical Treatment

Surgical treatment is the best option available for stage 2 or 3 ingrown nails, as conservative approaches have high rates of failure and recurrence. Many surgical techniques have been proposed (Table 2). Conventional surgical treatment of ingrown toenails has been associated with an unacceptably high recurrence rate, substantial postoperative pain, and poor cosmetic results.10,11 Simple nail edge excision has a recurrence rate of 39%,10,12 and total nail avulsion has a recurrence rate of 83%,13,14 whereas soft tissue resection has a cure rate of 60%.10,14,15 The reported recurrence rate after wedge resection ranges from 12% to 30%.10,16,17

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Table 2.

Treatment Options for Ingrown Toenails

Total nail bed ablation using the Zadik procedure is associated with considerable postoperative pain and recurrence rates ranging from 16% to 28%.18 Moreover, patients, particularly young women, often object to the inadequate cosmetic results.10 Excision of the proximolateral matrix segment is effective, and cure rates exceeding 95% have been reported, but this technique is technically difficult, and the associated overaggressive bone destruction can lead to osseous infection and complications19; however, if the technique is performed correctly, the risk of complications is very low. None of the patients in our study had evidence of osseous infection during follow-up, nor did any need analgesics beyond postoperative day 3.

Other nonsurgical treatment choices for destroying the nail matrix have limitations. Cryotherapy is associated with a high recurrence rate (36%).20 Newer methods of segmental nail bed ablation, including electrodessication, sodium hydroxide treatment, negative galvanic current therapy, and carbon dioxide laser treatment, provide good results, but are more expensive than phenol ablation.9,21-25

Zadik Technique

In 1950, Zadik18 reported a radical surgical technique for treating ingrown toenails, and Fowler26 subsequently described in detail use of this technique for bilateral and unilateral ingrown toenails.

For bilateral ingrown toenails (ie, those affecting medial and lateral aspects of the same nail), under local anesthesia and tourniquet control, 2 oblique 1.25-cm incisions are made, beginning at the junction of the nail fold and nail walls. Three skin-only flaps are dissected; the epithelium on the deep surfaces of the nail fold and nail walls is left intact. The nail is avulsed and the skin flaps retracted. Sharp dissection is used to remove a block of tissue: the germinal matrix and the overlying deep layer of the nail fold and walls. The skin flaps are then sutured back to cover the wound.

The technique for unilateral ingrown toenail is similar in all essentials to the above operation, except that the excision of the germinal matrix is limited to a wide segment at the corner of the nail. One skin incision is used and 2 flaps are raised to expose the germinal matrix of the affected side of the nail. The wound is completely covered by the skin flaps.

Certain aspects of the technique need emphasis. The operations must be exact dissections to the limits of the germinal matrix. Distally, the matrix is divided just beyond the edge of the lunular area; proximally, the dissection reaches nearly to the joint line; and laterally, it continues until the blade reaches the fatty tissue of the pulp. For total excision of the germinal matrix, the tissue is excised in 2 parts by starting from the midline and working to each side.26

Our procedure, described in Methods, differs from the Zadik procedure in its use of a longitudinal incision in the side of ingrown toenail, partial (vs total) extraction of the matrix, and addition of phenol ablation of the nail bed of the ingrown toenail. Excising the lateral and proximolateral matrices, in addition to nail avulsion, and using phenolization might more effectively reduce the recurrence rate.

Comparative Effectiveness of Techniques

The literature contains many reports of the effectiveness, cure rates, and complications of matrix cauterization with phenol in the treatment of ingrown nails.17,27-30 A Cochrane review has described the various methods for treating ingrown toenails.31 The authors noted that the combination of simple nail avulsion and phenolization was more effective than all other methods. In 2 of the studies reviewed, combination techniques—the Zadik procedure with phenolization, and the Winograd procedure with phenolization—were used in 31 and 170 patients, respectively, whereas other studies compared surgery alone with phenolization. Adding to the studies reported in the Cochrane review, our study had more patients and provides longer-term data on success rate.

Follow-up is key for evaluating treatment of ingrown toenails because recurrence can occur up to 2 years later. We obtained a 99.7% success rate at 2 years. We believe that our technique, using several treatments in a single procedure, ranks as one of the best for preventing recurrence and achieving a high success rate. We did not have a control group, however. Controlled studies comparing our technique with others are needed to determine which is most efficacious.

In conclusion, partial excision of the proximolateral matrix combined with phenolic ablation for the treatment of ingrown toenails was highly effective and is the treatment of choice at our clinic because of its high success rate in the long term. We believe that the surgical technique is the most important determinant of the success rate. Removing a sufficient width of nail (3 mm) and appropriate curettage after proximolateral matrix excision are the most critical factors for avoiding nail spicules in the sulcus or under the eponychium, and preventing recurrence after phenol chemical matricectomy.

Footnotes

  • Conflicts of interest: authors report none.

  • To read or post commentaries in response to this article, see it online at http://www.annfammed.org/content/10/6/556.

  • Received for publication September 27, 2011.
  • Revision received January 17, 2012.
  • Accepted for publication February 1, 2012.
  • © 2012 Annals of Family Medicine, Inc.

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Treatment of Ingrown Toenail With Proximolateral Matrix Partial Excision and Matrix Phenolization
Nezih Karaca, Tugrul Dereli
The Annals of Family Medicine Nov 2012, 10 (6) 556-559; DOI: 10.1370/afm.1406

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Treatment of Ingrown Toenail With Proximolateral Matrix Partial Excision and Matrix Phenolization
Nezih Karaca, Tugrul Dereli
The Annals of Family Medicine Nov 2012, 10 (6) 556-559; DOI: 10.1370/afm.1406
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