Article Figures & Data
Figures
- Figure 1
Preferred reporting items in systematic reviews and meta-analyses flow diagram of study selection, inclusion, and exclusion of randomized controlled trials evaluating cinnamon on glycemic and lipid parameters.
- Figure 2
Forest plot depicting the meta-analyses results of randomized controlled trials evaluating cinnamon on serum levels of hemoglobin A1c and fasting blood glucose.
Note: Squares represent individual studies, and size of the square represents the weight given to each study in the meta-analysis. Error bars represent 95% confidence intervals. The diamonds represent the pooled results. The solid vertical line extending upward from 0.00 is the null value.
- Figure 3
Forest plot depicting the meta-analysis results of randomized controlled trials evaluating cinnamon on serum levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides.
HDL=high-density lipoprotein; LDL=low-density lipoprotein.
Note: Squares represent individual studies, and size of the square represents the weight given to each study in the meta-analysis. Error bars represent 95% confidence intervals. The diamonds represent the pooled results. The solid vertical line extending upward from 0.00 is the null value.
Additional Files
Supplemental Table & Figures 1-2
Supplemental Table. Baseline Characteristics of Randomized Controlled Trials Evaluating Cinnamon Use; Supplemental Figure 1. Risk of bias assessment of randomized controlled trials (RCTs) evaluating cinnamon on glycemic and lipid parameters; Supplemental Figure 2. Forest plot depicting the results of cumulative meta-analyses of randomized controlled trials evaluating cinnamon on serum levels of hemoglobin A1c and fasting blood glucose based on year of publication.
Files in this Data Supplement:
- Supplemental data: Table - PDF file, 4 pages
- Supplemental data: Figures 1-2 - PDF file, 4 pages
The Article in Brief
Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis
Olivia J. Phung , and colleagues
Background Cinnamon has been studied in patients with type 2 diabetes for its effects on lowering blood glucose levels, but studies have been small and show conflicting results. This updated analysis of existing research examines cinnamon's effect on glycemia and lipids.
What This Study Found Consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, total cholesterol, low-density lipoprotein cholesterol and triglyceride, and an increase in high-density lipoprotein cholesterol. A meta-analysis of 10 randomized controlled trials evaluating the effects of cinnamon use in 543 patients with type 2 diabetes found reduced levels of fasting plasma glucose, total cholesterol, and triglycerides. Cinnamon also increased levels of HDL-C. No significant effect on hemoglobin A1c levels was seen.
Implications
- Despite the generally positive results, the authors advise caution in applying the results of this analysis to patient care because of the uncertainty of the dose and duration of cinnamon use and uncertainty of the ideal patient population.
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