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Research ArticleOriginal Research

Predictors of Chronic Abdominal Pain Affecting the Well-Being of Children in Primary Care

Leo A.A. Spee, Yvonne Lisman-van Leeuwen, Marc A. Benninga, Sita M. A. Bierma-Zeinstra, Boudewijn J. Kollen and Marjolein Y. Berger
The Annals of Family Medicine March 2015, 13 (2) 158-163; DOI: https://doi.org/10.1370/afm.1736
Leo A.A. Spee
1Department of General Practice, Erasmus MC University Medical Center, Rotterdam, the Netherlands
MD
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  • For correspondence: l.spee@erasmusmc.nl
Yvonne Lisman-van Leeuwen
1Department of General Practice, Erasmus MC University Medical Center, Rotterdam, the Netherlands
2Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
PhD
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Marc A. Benninga
3Department of Pediatric Gastroenterology, Emma Children’s Hospital/Academic Medical Center, Amsterdam, the Netherlands
MD, PhD
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Sita M. A. Bierma-Zeinstra
1Department of General Practice, Erasmus MC University Medical Center, Rotterdam, the Netherlands
PhD
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Boudewijn J. Kollen
2Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
PhD
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Marjolein Y. Berger
1Department of General Practice, Erasmus MC University Medical Center, Rotterdam, the Netherlands
2Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
MD, PhD
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Tables

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    Table 1

    Overview of Questions on the Somatic Complaints Syndrome Scale of the Child Behavior Checklist

    Questions for Children Aged 4–5 YearsQuestions for Children Aged 6–16 Years
    Do you/does your child experience:Do you/does your child experience:
    Pain in general (without medical explanation; not abdominal pain or headaches)?Pain in general (without medical explanation; not abdominal pain or headaches)?
    Headaches?Headaches?
    Nausea, feels sick?Nausea, feels sick?
    Constipation?Constipation?
    Vomiting, throwing up?Vomiting, throwing up?
    Can’t stand having things out of place?Problems with eyes (not if corrected by glasses)?
    Diarrhea or loose bowels (when not sick)?Rashes or other skin problems?
    Doesn’t eat well?Nightmares?
    Painful bowel movements?Feels dizzy or lightheaded?
    Too concerned with neatness or cleanliness?Overtired without good reason?
    • View popup
    Table 2

    Univariate Association of Candidate Predictors With Chronic Abdominal Pain

    PredictorCAP (n = 105)No CAP (n = 178)Original OR (95% CI)aPooled OR (95% CI)bP Valuec
    Candidate positive predictors
     Age, mean (SD), y8.8 (3.2)8.0 (2.7)1.10 (1.02–1.20)1.09 (1.00–1.18).05
     Sex, female, No. (%)73 (69.5)104 (58.4)1.62 (0.97–2.71)1.47 (0.89–2.44).14
     Dyspepsia, No. (%)53 (50.5)74 (44.0)1.30 (0.79–2.11)1.27 (0.78–2.06).33
     Waking up at night because of pain, No. (%)53 (50.5)56 (31.5)2.22 (1.35–3.65)2.08 (1.29–3.36).003
     Overweight, No. (%)d15 (14.3)13 (7.3)2.12 (0.96–4.64)1.81 (0.82–4.00).14
     High level of other somatic symptoms, No. (%)28 (26.7)20 (11.2)2.87 (1.52–5.42)2.58 (1.38–4.82).003
     CAP at baseline, No. (%)58 (55.2)73 (41.0)1.78 (1.09–2.89)1.63 (1.01–2.62).04
     Parent with functional GI complaints, No. (%)37 (35.6)49 (28.0)1.42 (0.85–2.39)1.60 (0.88–2.90).13
    Candidate negative predictors
     Vomiting, No. (%)16 (15.2)30 (16.9)0.89 (0.46–1.72)0.91 (0.47–1.75).77
     Fever, No. (%)20 (19.0)28 (15.7)1.26 (0.67–2.37)1.23 (0.65–2.31).52
     Dysuria, No. (%)8 (7.6)9 (5.1)1.55 (0.58–4.15)1.36 (0.31–3.62).53
     Blood on stools, No. (%)3 (2.9)4 (2.3)1.27 (0.28–5.80)1.15 (0.25–5.29).86
     Epigastric pain, No. (%)5 (4.9)20 (12.6)0.36 (0.13–0.99)0.45 (0.18–1.10).08
    • CAP = chronic abdominal pain; GI = gastrointestinal; OR = odds ratio.

    • ↵a Original data set ORs.

    • ↵b Pooled ORs after multiple imputation.

    • ↵c P values of imputed data.

    • d According to body mass index using child-adjusted cutoff points.21

    • View popup
    Table 3

    Multivariate Association of Candidate Predictors With Chronic Abdominal Pain

    PredictorOR (95% CI)aP Valueb
    Positive predictors
     Age1.08 (0.99–1.17).09
     Waking up at night because of pain2.28 (1.38–3.77).001
     High levels of other somatic symptoms2.18 (1.14–4.19).02
     CAP at baseline1.77 (1.07–2.95).03
    Negative predictors
     Epigastric pain0.45 (0.18–1.10).08
    • CAP = chronic abdominal pain; OR = odds ratio.

    • ↵a Pooled ORs after multiple imputation.

    • ↵b P value of imputed data. Values were statistically significant if less than .157.

    • View popup
    Table 4

    Risk of Chronic Abdominal Pain by Number of Positive Predictors

    Number of PredictorsaOdds Ratiob (95% CI)Absolute Risk,c %
    0Reference19.4
    12.25 (0.92–5.48)34.9
    23.91 (1.52–10.08)48.2
    3 or 48.00 (2.90–22.09)65.5
    • ↵a Out of age ≥10 years, waking up at night because of pain, high levels of other somatic symptoms, and chronic abdominal pain at baseline.

    • ↵b Pooled ORs after multiple imputation.

    • ↵c After multiple imputation.

Additional Files

  • Tables
  • The Article in Brief

    Predictors of Chronic Abdominal Pain Affecting the Well-Being of Children in Primary Care

    Leo A. A. Spee , and colleagues

    Background Abdominal pain is a frequent complaint among children but its prognosis is difficult to predict. The ability to identify children at risk for long-term abdominal pain would help clinicians make more appropriate management decisions at an earlier stage. This study seeks to identify characteristics that can predict chronic abdominal pain severe enough to influence the child's wellbeing at 1-year follow-up.

    What This Study Found More than one in three children coming to a family practice with abdominal pain have persistent pain affecting quality of life after one year. Increased age, waking up at night with pain, high levels of other physical complaints, and chronic abdominal pain at the initial visit independently predict chronic pain at one year. The probability of having chronic abdominal pain after one year ranges from 19 percent in children with none of the predictors to 66 percent among those having three or four. However, the predictors collectively explain only 14 percent of variance in the development of chronic abdominal pain.

    Implications

    • On the basis of medical evaluation alone, the family physician is unable to accurately predict the prognosis of a child with abdominal pain. Other yet to be identified psychosocial, environmental or family stressors may play a role.
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The Annals of Family Medicine: 13 (2)
The Annals of Family Medicine: 13 (2)
Vol. 13, Issue 2
March/April 2015
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Predictors of Chronic Abdominal Pain Affecting the Well-Being of Children in Primary Care
Leo A.A. Spee, Yvonne Lisman-van Leeuwen, Marc A. Benninga, Sita M. A. Bierma-Zeinstra, Boudewijn J. Kollen, Marjolein Y. Berger
The Annals of Family Medicine Mar 2015, 13 (2) 158-163; DOI: 10.1370/afm.1736

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Predictors of Chronic Abdominal Pain Affecting the Well-Being of Children in Primary Care
Leo A.A. Spee, Yvonne Lisman-van Leeuwen, Marc A. Benninga, Sita M. A. Bierma-Zeinstra, Boudewijn J. Kollen, Marjolein Y. Berger
The Annals of Family Medicine Mar 2015, 13 (2) 158-163; DOI: 10.1370/afm.1736
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Subjects

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