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Research ArticleOriginal Research

A Hepatitis C Treatment Program Based in a Safety-Net Hospital Patient-Centered Medical Home

Karen E. Lasser, Alexandra Heinz, Leandra Battisti, Alexandria Akoumianakis, Ve Truong, Judith Tsui, Glorimar Ruiz and Jeffrey H. Samet
The Annals of Family Medicine May 2017, 15 (3) 258-261; DOI: https://doi.org/10.1370/afm.2069
Karen E. Lasser
1Section of General Internal Medicine, Boston Medical Center, Boston, Massachusetts
2Boston University Schools of Medicine and Public Health, Boston, Massachusetts
3Boston Medical Center, Boston, Massachusetts
MD, MPH
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  • For correspondence: Karen.lasser@bmc.org
Alexandra Heinz
3Boston Medical Center, Boston, Massachusetts
LCSW, MPH
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Leandra Battisti
3Boston Medical Center, Boston, Massachusetts
PharmD
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Alexandria Akoumianakis
3Boston Medical Center, Boston, Massachusetts
CPhT
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Ve Truong
1Section of General Internal Medicine, Boston Medical Center, Boston, Massachusetts
BS
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Judith Tsui
4Division of General Medicine, Harborview Medical Center, University of Washington, Seattle, Washington
MD, MPH
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Glorimar Ruiz
3Boston Medical Center, Boston, Massachusetts
MD
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Jeffrey H. Samet
1Section of General Internal Medicine, Boston Medical Center, Boston, Massachusetts
2Boston University Schools of Medicine and Public Health, Boston, Massachusetts
3Boston Medical Center, Boston, Massachusetts
MD, MA, MPH
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  • Author response to Dr. Miller regarding HCV treatment in primary care
    Karen E Lasser
    Published on: 10 November 2017
  • A New Era for HCV Treatment Models
    Lesley S. Miller
    Published on: 09 November 2017
  • Response to Dr. Yawn
    Karen E Lasser
    Published on: 15 May 2017
  • Timely opportunity
    Barbara P Yawn
    Published on: 15 May 2017
  • Published on: (10 November 2017)
    Page navigation anchor for Author response to Dr. Miller regarding HCV treatment in primary care
    Author response to Dr. Miller regarding HCV treatment in primary care
    • Karen E Lasser, Associate Chief, Section of General Internal Medicine

    We thank Dr. Miller, who is a generalist pioneer in treating HCV at Grady Hospital, for her positive response to our program. While an ongoing challenge is a high missed appointment rate, we find that patients who do attend appointments are able to achieve cure. We wish that similar interdisciplinary, public health oriented programs could be implemented to address other primary care issues such as diabetes. Ironically, it...

    Show More

    We thank Dr. Miller, who is a generalist pioneer in treating HCV at Grady Hospital, for her positive response to our program. While an ongoing challenge is a high missed appointment rate, we find that patients who do attend appointments are able to achieve cure. We wish that similar interdisciplinary, public health oriented programs could be implemented to address other primary care issues such as diabetes. Ironically, it is the high price of HCV medications that facilitates 340b support of our HCV program.

    Competing interests: None declared

    Show Less
    Competing Interests: None declared.
  • Published on: (9 November 2017)
    Page navigation anchor for A New Era for HCV Treatment Models
    A New Era for HCV Treatment Models
    • Lesley S. Miller, Medical Director, Grady Liver Clinic

    I was pleased to see "A Hepatitis C Treatment Program Based in a Safety-Net Hospital Patient-Centered Medical Home" by Dr. Lasser and colleagues published in Annals of Family Medicine. The paper describes a public health oriented program that uses a multidisciplinary team, including general internists, to provide HCV care and treatment for patients in an urban patient centered medical home. The program demonstrated succ...

    Show More

    I was pleased to see "A Hepatitis C Treatment Program Based in a Safety-Net Hospital Patient-Centered Medical Home" by Dr. Lasser and colleagues published in Annals of Family Medicine. The paper describes a public health oriented program that uses a multidisciplinary team, including general internists, to provide HCV care and treatment for patients in an urban patient centered medical home. The program demonstrated success in navigating patients through a complex care cascade and revealed 100% cure rates with antiviral therapy.

    Exploring novel and patient-centered alternative models to traditional HCV care is particularly salient in 2017. With the new era of all-oral, easy to tolerate, short course direct acting antiviral therapy for HCV firmly upon us, we need to adapt treatment models accordingly. We have a new paradigm for antivirals, and we need a new paradigm for HCV models of care.

    Dr. Lasser's program highlights some key features that are integral to the success of these new models. First, taking a public health perspective is crucial. We have the opportunity to eliminate HCV, and critical to this is employing population management strategies. We have excellent cure rates for patients who make it to the final stages of the care cascade, but identifying infected patients guiding them through the cascade stages that precede treatment remains challenging. Perhaps HCV programs based in primary care and led by generalists, ideally with input from colleagues in public health, are the ideal venues in which to embark on small scale elimination programs.

    Second, similar to Dr. Lasser, we have found that multidisciplinary teams are integral to a successful HCV program. Our primary care-based HCV treatment program at Grady Memorial Hospital relies on clinical pharmacists, pharmacy techs and patient navigators working in concert with general internists to achieve successful treatment outcomes.

    Finally, it is important that Dr. Lasser and team highlighted the contribution of the 340b drug discount program to the success of their HCV treatment program. One of the main concerns voiced by those considering launching programs to expand HCV care is how to fund them. This paper provides a great example of successfully leveraging revenue generated from the 340b program to invest into the HCV program. This is the model we use and one that can be easily replicated at other sites that participate in the 340b program.

    I hope we will be seeing increasing reports of programs like Dr. Lasser's that demonstrate the success of primary care-based, generalist- run HCV treatment. We have the antiviral treatment tools we need to eliminate HCV; now we need to demonstrate equal success with screening and access to care and treatment.

    Competing interests: None declared

    Show Less
    Competing Interests: None declared.
  • Published on: (15 May 2017)
    Page navigation anchor for Response to Dr. Yawn
    Response to Dr. Yawn
    • Karen E Lasser, Physician

    Dear Dr. Yawn, Thank you for the kind comments on our paper. I'd like to point out that the 340B pharmacy benefit was instrumental in launching and sustaining our program. Safety-net practices may be eligible for this benefit and, if so, could implement a similar HCV treatment program in primary care. Best, Karen Lasser

    Competing interests: None declared

    Competing Interests: None declared.
  • Published on: (15 May 2017)
    Page navigation anchor for Timely opportunity
    Timely opportunity
    • Barbara P Yawn, Adjunct Professor

    I congratulate Dr. Lasser and her colleagues on tackling an important gap in current care of the many individuals with recognized and unrecognized hepatitis C. To date many patients have had to seek care from subspecialists for confirmation and treatment of their hepatitis C resulting in a high level of unmet needs among primary care patients. This work clearly demonstrates the ability and feasibility of including cu...

    Show More

    I congratulate Dr. Lasser and her colleagues on tackling an important gap in current care of the many individuals with recognized and unrecognized hepatitis C. To date many patients have had to seek care from subspecialists for confirmation and treatment of their hepatitis C resulting in a high level of unmet needs among primary care patients. This work clearly demonstrates the ability and feasibility of including current hepatitis C management in family medicine and safety-net practices. The recent (May 12, 2017) MMWR from the CDC (https://www.cdc.gov/mmwr/volumes/66/wr/pdfs/mm6618.pdf) highlights the 4 fold increase in hepatitis C incidence cases and further strengthens the need to expand this program to other sites and practices.

    Competing interests: None declared

    Show Less
    Competing Interests: None declared.
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The Annals of Family Medicine: 15 (3)
The Annals of Family Medicine: 15 (3)
Vol. 15, Issue 3
May/June 2017
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A Hepatitis C Treatment Program Based in a Safety-Net Hospital Patient-Centered Medical Home
Karen E. Lasser, Alexandra Heinz, Leandra Battisti, Alexandria Akoumianakis, Ve Truong, Judith Tsui, Glorimar Ruiz, Jeffrey H. Samet
The Annals of Family Medicine May 2017, 15 (3) 258-261; DOI: 10.1370/afm.2069

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A Hepatitis C Treatment Program Based in a Safety-Net Hospital Patient-Centered Medical Home
Karen E. Lasser, Alexandra Heinz, Leandra Battisti, Alexandria Akoumianakis, Ve Truong, Judith Tsui, Glorimar Ruiz, Jeffrey H. Samet
The Annals of Family Medicine May 2017, 15 (3) 258-261; DOI: 10.1370/afm.2069
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