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Year Title of POEM Reference 1998 Metformin is best for obese patients with type 2 diabetes mellitus UK Prospective Diabetes Study Group10 1999 β-Blockers are effective in heart failure Lechat P, et al11 2000 3 Years between Papanicolaou tests are adequate for many women Sawaya GF, et al12 2001 Managing heart rate and rhythm are similar for atrial fibrillation Hohnloser SH, et al13 2002 Hormone replacement overall is not beneficial Writing Group for the Women’s Health Initiative Investigators14 2003 Self-breast examination does not reduce mortality Thomas DB, et al15 2004 Breast cancer screening results in overdiagnosis Zahl P, et al16 2005 Vaccine prevents human papillomavirus infection Harper DM, et al17 2006 Delayed prescription for acute otitis media reduces unnecessary antibiotics Spiro DM, et al18 2007 Home blood glucose monitoring is ineffective for type 2 diabetes mellitus Farmer A, et al19 2008 Intensive control of blood glucose in type 2 diabetes mellitus may be harmful Gerstein HC, et al20 2009 Prostate-specific antigen screening does not reduce mortality from prostate cancer Andriole GL, et al21 2010 Statin + fenofibrate is no better than statin alone in type 2 diabetes mellitus The ACCORD Study Group22 2011 Rivaroxaban is similar to warfarin for patients with nonvalvular atrial fibrillation Patel MR, et al23 2012 Conservative therapy with antibiotics is an option for early uncomplicated acute appendicitis Varadhan KK, et al24 2013 Fasting is not necessary before measuring lipid panels Sidhu D and Naugler C25 2014 Niacin does not improve clinical outcomes in patients with vascular disease The HPS2-THRIVE Collaborative Group, Landray MJ, et al26 2015 Steroids are beneficial as adjunctive treatment for community-acquired pneumonia Siemieniuk RAC, et al27 2016 Active surveillance for localized prostate cancer: no increased mortality, but higher rates of clinical progression Hamdy FC, et al28 2017 Semaglutide reduces cardiovascular events in high-risk patients with type 2 diabetes mellitus Marso SP, et al29 POEM = patient-oriented evidence that matters.
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