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Research ArticleOriginal Research

Chronic Opioid Prescribing in Primary Care: Factors and Perspectives

Sebastian T. Tong, Camille J. Hochheimer, E. Marshall Brooks, Roy T. Sabo, Vivian Jiang, Teresa Day, Julia S. Rozman, Paulette Lail Kashiri and Alex H. Krist
The Annals of Family Medicine May 2019, 17 (3) 200-206; DOI: https://doi.org/10.1370/afm.2357
Sebastian T. Tong
Virginia Commonwealth University, Richmond, Virginia
MD, MPH
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  • For correspondence: sebastian.tc.tong@gmail.com
Camille J. Hochheimer
Virginia Commonwealth University, Richmond, Virginia
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E. Marshall Brooks
Virginia Commonwealth University, Richmond, Virginia
PhD
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Roy T. Sabo
Virginia Commonwealth University, Richmond, Virginia
PhD
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Vivian Jiang
Virginia Commonwealth University, Richmond, Virginia
MD
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Teresa Day
Virginia Commonwealth University, Richmond, Virginia
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Julia S. Rozman
Virginia Commonwealth University, Richmond, Virginia
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Paulette Lail Kashiri
Virginia Commonwealth University, Richmond, Virginia
MPH
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Alex H. Krist
Virginia Commonwealth University, Richmond, Virginia
MD, MPH
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Tables

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    Table 1

    Top 10 Prescribed Opioids in Primary Care Clinics, by Setting

    Urban, Underserved ClinicsSuburban Clinics
    Ranking Within Overall PrescriptionsaMedication NameNo. (Percentage of Total Prescriptions)Ranking Within Overall PrescriptionsaMedication NameNo. (Percentage of Total Prescriptions)
    6Oxycodone3,365 (2.5)47Codeine-guaifenesin2,271 (0.6)
    8Acetaminophen-oxycodone2,873 (2.1)56Hydrocodone-acetaminophen2,039 (0.5)
    13Acetaminophen-hydrocodone2,074 (1.6)60Hydrocodone-chlorpheniramine1,873 (0.5)
    15Tramadol1,855 (1.4)61Oxycodone-acetaminophen1,855 (0.5)
    61Fentanyl554 (0.4)68Tramadol1,680 (0.4)
    85Morphine418 (0.3)102Oxycodone865 (0.2)
    88Codeine-guaifenesin398 (0.3)134Acetaminophen-codeine621 (0.2)
    95Methadone368 (0.3)196Morphine295 (0.1)
    117Chlorpheniramine-hydrocodone291 (0.2)232Promethazine-codeine221 (0.1)
    131Acetaminophen-codeine246 (0.2)236Hydromorphone210 (0.1)
    • ↵a This ranking compares the top 10 prescribed opioids with all prescriptions (including nonopioid prescriptions) at 21 primary care clinics. Note that opioids can be prescribed only at monthly intervals without refills, whereas other medications may have refills that can last for up to 1 year.

    • View popup
    Table 2

    Demographic Characteristics and Risk Profiles for Opioid-Related Harms of Patients Receiving Chronic Opioids

    Patients on Chronic Opioids, n = 902 (%)aPatients Not on Chronic Opioids, n = 84,027 (%)aP Value
    Demographic characteristics
    Sex, female591 (65.5%)50,575 (60.2%)<.01
    Race
     Asian/Asian American6 (0.7%)6,034 (7.2%)<.01
     Black/African American389 (43.1%)12,377 (14.7%)
     White435 (48.2%)48,200 (57.4%)
     Other20 (2.2%)4,509 (5.4%)
     Declined52 (5.8%)12,907 (15.4%)
    Ethnicity, Hispanic12 (1.4%)3,576 (5.4%)<.01
    Medical comorbidities
    Sleep apnea194 (21.5%)7001 (8.3%)<.01
    Depression or anxiety537 (59.5%)23,693 (28.2%)<.01
    Substance use disorder118 (13.1%)1,802 (2.1%)<.01
    Hepatic insufficiency153 (17.0%)4,020 (4.8%)<.01
    Renal insufficiency174 (19.3%)2,439 (2.9%)<.01
    Concurrent benzodiazepine prescription216 (24.0%)714 (8.3%)b<.01
    • ↵a The denominator for all percentages is the n listed in the column heading unless otherwise indicated.

    • ↵b Because concurrent benzodiazepine prescription is relevant only for patients with an opioid prescription, the denominator here is 8,560 to account for patients who have received an opioid prescription in 2016.

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    Table 3

    Variation in Daily Morphine Milligram Equivalent (MME) for Patients on Chronic Opioids by Patient, Clinician, and Clinic Characteristics

    CharacteristicsNMedian Daily MME (IQR)Kruskal-Wallis P Value
    Patient level
    SexFemale59130.0 (15.0-51.4).06
    Male31130.0 (15.9-60.0)
    RaceAsian/Asian American613.7 (5.8-36.3)<.01
    Black/African38930.0 (20.0-52.5)
    American
    White43530.0 (13.7-60.0)
    Other2024.2 (11.3-59.6)
    Declined5213.1 (5.7-30.7)
    EthnicityHispanic1220.6 (5.8-49.4).08
    Not Hispanic82030.0 (15.7-57.2)
    Sleep apneaYes19430.0 (20.0-57.2).08
    No70830.0 (15.0-55.5)
    Depression or anxietyYes53731.5 (16.7-60.0)<.01
    No36525.6 (15.0-48.3)
    Substance use disorderYes11841.4 (22.5-82.5)<.01
    No78430.0 (15.0-52.5)
    Hepatic insufficiencyYes15338.9 (18.2-60.0).01
    No74930.0 (15.0-53.7)
    Renal insufficiencyYes17430.0 (20.0-60.0).03
    No72830.0 (15.0-54.0)
    Concurrent benzodiazepine prescriptionYes21631.0 (15.0-69.6).09
    No68630.0 (15.0-51.1)
    Clinician level
    Degree typeMD15743.3 (19.1-67.7)<.01
    DO1038.6 (26.3-57.9)
    NP2118.4 (7.1-57.0)
    PA75.1 (3.0-14.6)
    Other120.0 (20.0-20.0)
    Age<5013743.4 (18.2-61.7).24
    ≥504335.1 (14.0-56.5)
    SexFemale11333.6 (11.2-53.2)<.01
    Male8346.8 (25.1-69.7)
    SpecialtyFamily medicine10318.2 (7.5-42.0)<.01
    Internal medicine9351.0 (40.1-74.2)
    Trainee or attending statusAttending13125.4 (9.2-56.5)<.01
    Resident6552.5 (40.2-71.0)
    Clinic level
    TypeUrban, underserved861.6 (54.4-65.4).05
    Suburban1026.1 (15.0-57.6)
    Number of clinicians<5 clinicians525.1 (13.7-51.0).26
    5+ clinicians1357.7 (28.3-64.1)
    Training site?Residents268.3 (64.1-72.5).09
    No residents1640.0 (22.1-61.6)
    • View popup
    Table 4

    Themes and Findings From Clinician Interviews

    ThemesFindingsExample Quotes
    Inheriting patients on chronic opioidsClinicians feel frustrated after inheriting patients with chronic pain on opioids.“Her pain doctor got fired or, you know, loss of license (I can’t remember what happened) so she came to me very angry, very difficult conversation wanting to be on the same huge doses.”
    Clinicians feel pressured to manage inappropriate amounts or types of chronic opioids.“I get a call from the case manager who says would you be willing to consider the following: Would you be willing to consider prescribing her methadone as a pain management medication and not as methadone maintenance for her substance abuse disorder…. Looking back now it’s one of these …what the heck was I thinking kind of thing…. I sort of felt like I was getting stiff-armed into things.”
    Primary care often becomes the default chronic pain medication manager.“She is seeing a psychiatrist, a pain specialist, an orthopedist, and a rheumatologist. She’s got all of these people involved in her care but, for some reason, I’m the person who stuck with her pain med management and nobody is super-eager to touch that.”
    Co-occurring health problemsExtent or complexity of medical comorbidities often takes priority.“He’s kind of a mess…. Bad asthma. Bad COPD. Bad heart. He’s been in the hospital more than he’s been out and was diagnosed with leukemia about six months ago. I told him, you know, your pain pills are the least of my concerns; whatever it takes to get you through the day.”
    Patients with chronic pain often have complex social situations.“She’s someone I’ve been trying to wean but her social situation is just a disaster. She’s leaving an abusive relationship. I think she’s actually homeless right now.”
    Contraindication of nonopioid pain medications limits pain management strategies.“I will say that the older ones …have crappy kidneys and contraindications to a lot of other things that you could actually put them on to help with their pain.”
    Access to adjunctive pain management strategies is limited.“She’s stable and is a single mom working and has limited access to adjunctive therapies and physical therapies. I’m a little stuck on her.”
    Benefits of opioids for chronic pain managementChronic opioids are necessary to sustain functional capacity and quality of life.“I feel like a change is not indicated at this time because she needs the medication in order to do her job and go to work and help her family, and it is working for her. She is overall low-risk for abuse. I don’t feel compelled to make a change for her.”
    Chronic opioids help manage chronic diseases.“She’s got chronic pancreatitis and without this dose she can’t eat and she gets malnourished and gets really sick.”
    Challenges with weaningClinicians lack time to manage chronic opioids.“It might be different if I were a chronic pain management doctor and I was seeing 20 patients a day every day and just doing this.”
    Lack of control over other sources of opioids undermines weaning attempts.“The amount of narcotics she gets in the hospital blows us out of the water. The problem is she is on around-the-clock high-dose IV-pain medicine when she goes to the hospital.”
    Clinicians have a hard time justifying weaning stable patients receiving long-term opioid pain management.“It’s very hard with patients who have been on them [a long time] to get them off…. Five to seven years ago, [when many of my patients started on opioid], this wasn’t even part of the cultural discussion. It was like patients just came in and demanded these medications, they could be downright hostile with you. Now, I could tell them we’re going to wean down, but it would be a really ugly fight.”

Additional Files

  • Tables
  • The Article in Brief

    Chronic Opioid Prescribing in Primary Care: Factors and Perspectives

    Sebastian Tong , and colleagues

    Background Primary care clinicians write almost half of all opioid prescriptions in the United States but little is known about the characteristics of these clinicians and their patients who receive opioids. This study describes patient and clinician characteristics and clinicians' perspectives of chronic opioid prescribing in primary care

    What This Study Found Chronic opioid prescribing in primary care varies significantly by patient and clinician characteristics. This analysis of 2016 electronic health record data included 21 primary care practices, 271 clinicians, and 84,929 patients. Eleven percent of patients seen received an opioid prescription, while 1% received chronic opioid prescriptions. Oxycodone-acetaminophen was the most commonly prescribed opioid, followed by oxycodone. In urban underserved clinics, 10% of prescriptions written were for opioids, compared to 3% of prescriptions in suburban clinics. Being female, being of black race, and having risks for opioid-related harms, such as mental health diagnoses, substance use disorder and concurrent benzodiazepine use, were associated with being prescribed chronic opioids. Patients with higher comorbidities were more likely to receive chronic opioid prescriptions and at higher doses. In interviews, clinicians described the use of opioids to manage chronic pain as appropriate for patients with extensive medical comorbidities or patients for whom non-opioid pain medications were contraindicated. However, most were reluctant to begin patients on opioids for chronic pain. Many felt frustrated by lack of time to appropriately manage patients� chronic pain and lack of control over patients' access to other sources of opioids.

    Implications

    • The authors call for research to explore trends in opioid prescribing, compare the differences in opioid prescribing in various settings, and test interventions to help primary care clinicians overcome barriers in weaning patients with high risks of opioid-related harms.
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The Annals of Family Medicine: 17 (3)
The Annals of Family Medicine: 17 (3)
Vol. 17, Issue 3
May/June 2019
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Chronic Opioid Prescribing in Primary Care: Factors and Perspectives
Sebastian T. Tong, Camille J. Hochheimer, E. Marshall Brooks, Roy T. Sabo, Vivian Jiang, Teresa Day, Julia S. Rozman, Paulette Lail Kashiri, Alex H. Krist
The Annals of Family Medicine May 2019, 17 (3) 200-206; DOI: 10.1370/afm.2357

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Chronic Opioid Prescribing in Primary Care: Factors and Perspectives
Sebastian T. Tong, Camille J. Hochheimer, E. Marshall Brooks, Roy T. Sabo, Vivian Jiang, Teresa Day, Julia S. Rozman, Paulette Lail Kashiri, Alex H. Krist
The Annals of Family Medicine May 2019, 17 (3) 200-206; DOI: 10.1370/afm.2357
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