Article Figures & Data
Figures
- Figure 1.
Prisma flowchart of included articles.
- Figure 2.
Difference in assay sensitivity between vaginal swabs and urine in the detection of Chlamydia trachomatis.
OR = odds ratio.
a Non-calculable due to 100% sensitivity.
- Figure 3.
Difference in assay sensitivity between vaginal swabs and urine in the detection of Neisseria gonorrhoeae.
OR = odds ratio.
- Figure 4.
Difference in assay sensitivity between vaginal swabs and urine in the detection of Trichomonas vaginalis.
OR = odds ratio.
a Non-calculable due to 100% sensitivity.
Tables
First Author, Year Population Organism Studied Index Assay Quality Reference Standard Wiesenfeld,35 1996 STD clinic attendees at a health department in the US CT Roche Amplicor PCR Culture, alternate target NAAT Hjelm,22 2001 Venereology department or Youth Health Clinic attendees at a university in Sweden CT Abbott LCR Culture, alternate target NAAT, multiple site NAAT positive Knox,18 2002 Local clinic attendees in Australia requiring a pelvic exam CT, NG Roche Amplicor PCR Multiple site Amplicor positives, alternate target NAAT Schachter,27 2003 Army recruits entering basic training in the US CT (1) Abbott LCR
(2) Roche Amplicor PCR
(3) Hologic Amplified TMA/HPA CT
AssayCulture multiple site NAAT positives Shrier,28 2004 Those receiving routine gynecologic care at an outpatient facility in the US CT Roche Amplicor PCR Culture, multiple site NAAT positives, alternate target NAAT Schachter,9 2005 Attendees of STD, OB/GYN, teen, and family planning clinics in the US and Canada. CT, NG Hologic TMA/HPA AC2 Multiple site NAAT positives alternate target NAAT Chernesky,20 2006 Attendees of a street youth clinic or a sexual health awareness center in Canada CT (1) Hologic TMA/HPA AC2
(2) Roche Amplicor PCR
(3) BD ProbeTec SDAMultiple site NAAT positives, alternate target NAAT Skidmore,29 2006 Participants in the Chlamydia Screening Studies project in the UK CT Roche Amplicor PCR and BD ProbeTec SDA Confirmed by EIA, or alternate target NAAT Renton,25 2006 Women presenting for termination of pregnancy in the UK CT Abbott LCR Referent is any direct fluorescent antibody, or Abbott LCR positive result Blake,17 2008 Attendees at STD clinics in the US CT Hologic TMA/HPA AC2 Confirmed by alternate target NAAT Nye,40 2009 Attendees at 1 STD clinic in the US TV Hologic Aptima TMA/HPA TV Microscopy, culture, an alternate target NAAT Schwebke,42 2011 Attendees at US OB/GYN, family planning, or STD clinics TV Hologic Aptima TMA/HPA TV Wet microscopy and culture Taylor,30 2011 Attendees at US OB/GYN, family planning, or STD clinics CT BD ProbeTec SDA 2 alternate NAATs LeRoy,23 2012 STD clinic attendees in Bordeaux, France CT Bio-Rad Dx CT/NG/MG PCR assay Alternate target NAAT Van Der Pol,36 2012 Attendees at US OB/GYN, family planning, or STD clinics NG BD ProbeTec SDA 2 alternate target NAATs Jang,38 2012 Street youth clinic or community health center attendees in Canada TV Hologic Aptima TMA/HPA TV Multiple sites positive, alternate target NAAT Van Der Pol,32 2013 Attendees at US OB/GYN, family planning, or STD clinics CT, NG Roche Cobas PCR 2 alternate target NAATs Gaydos,21 2013 Sexually active symptomatic and asymptomatic women attending OB/GYN, STD, teen, public health, or family planning clinics CT, NG Cepheid CT/NG Xpert Rapid PCR Test 2 alternate target NAATs Chernesky,19 2014 Women attending sexual health centers in Hamilton and Toronto, Ontario, Canada CT, NG (1) Hologic TMA/HPA AC2 on the Tigress
(2) Hologic TMA/HPA AC2 on the Panther
(3) Abbott RealTime CT/NG PCR
(4) BD ProbeTec SDA
(5) Roche Cobas PCR2 alternate NAATs Rumyantseva,26 2015 Women that attended a Swedish STI clinic were invited to participate CT Multiplex RT AmpliSens N.gonorrhoeae/C.trachomatis/M.genitalium/T.vaginalis-Multiprime-FRT PCR assay 2 alternate NAATs Van Der Pol,34 2017 Attendees at US OB/GYN, family planning, or STD clinics CT, NG, TV BD Max CT/GC/TV PCR Multiple site NAAT positives, alternate target NAAT for CT and NG; for TV, microscopy, culture and alternate target NAAT defined the composite infection standard. Gaydos,37 2017 Attendees at US OB/GYN, family planning, or STD clinics TV Solana TV HDA Assay Microscopy and culture defined the composite infection standard; however, for samples that were positive by Solana® and negative by microscopy/culture, an alternate NAAT was used as a confirmation of a true positive. Schwebke,41 2018 Attendees at US OB/GYN, family planning, or STD clinics TV Cepheid Xpert TV PCR Culture and alternate target NAAT Marlowe,39 2019 Women from Germany, Ukraine, and US who were at risk of infection, or consulted a healthcare provider for TV screening, or were found to be positive for TV during routine testing TV Roche cobas TV/MG PCR 3 alternate target NAATs Nye,24 2019 Attendees at US OB/GYN, family planning, or STD clinics CT, NG Roche cobas CT/NG PCR 2 alternate target NAATs Van Der Pol,31 2019 Attendees at US OB/GYN, family planning, or STD clinics CT, NG Roche cobas CT/NG PCR 2 alternate target NAATs Van Der Pol,43 2021 Attendees at US OB/GYN, family planning, or STD clinics TV Roche cobas TV/MG PCR Culture and alternate target NAAT Van Der Pol,33 2021 Attendees at US OB/GYN, family planning, or STD clinics CT, NG, TV (1) BD CTGCTV2 PCR
(2) Hologic TMA/HPA AC2
(3) BD ProbeTec SDAMultiple sites positive, alternate target NAATs AC2 = aptima combo 2; BD = Becton, Dickinson and Company; CT = Chlamydia trachomatis; CTGCTV2 = BD MAX System assay; FRT = fluorescent resonance energy transfer ; GC = BD’s abbreviation for NG ; HDA = helicase-dependent amplification; HPA = hybridization protection assay; LCR = ligase chain reaction; MG = Mycoplasma genitaium; NAAT = nucleic acid amplification testing; NG = Neisseria gonorrhoeae; OB/GYN = obstetrics and gynecology; PCR = polymerase chain reaction; RT = real-time ; SDA = strand displacement amplification; STD = sexually transmitted disease; STI =sexually transmitted infection; TMA = transcription mediated amplification; TV = Trichomonas vaginalis; US = United States.
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