Effect of Psyllium Fiber Supplementation on C-Reactive Protein: The Trial to Reduce Inflammatory Markers (TRIM)

Editors,

I agreee with authors's conclusion exclusively in obese and overweight individuals, from the clinical viewpoint. In fact, Bed-Side Evaluating Acute Phase Proteins (APP), including C Reactive Protein (CRP), is nowadays possible by means of Biophysical Semeiotics (See my site www.semeioticabiofisica.it, Practical Applications: http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/C%20Reactive%20Protein%) APP are numerous proteins, synthesized by the liver; their bed-side evaluation has proved to be useful, from both diagnostic and prognostic view-point, as allows me to state a 52-year-long well-established “clinical” experience. In addition, such as original assessement represents an useful clinical tool in research, and permits doctor to perform therapeutic monitoring in a new, remarkable, and reliable way, also in consideration of the probable role plaied by chronic inflammation in CVD. As I wrote in above-cited site (“Biophysical Semeiotic Constitutions”) all possible “risk factors”, by different pathogenetic action mechanisms, must necessarily act on a particular “constitutional terrain” in order to provoke one or more of the most common and serious human diseases, since genetic alterations, both “parenchymal” and “microcirculatory”, well located in a precise biological system, represent the base of different constitutions, conditio sine qua non of the deleterious effects caused by “risk factors”, sometimes by means of inflammations. From biophysical-semeiotic view-point, I demonstrated that the genetic abnormality to produce APP, including CRP, in a larger amount than normally, i.e. in healthy subjects, takes part of different “constitutions” , which predispose to DM, dyslipidaemia, arterial hypertension, rheumatic diseases, arteriosclerosis, and malignancy. In a few words, inflammation, revealed by increased production of APP, and particularly CRP in CAD, indicates exclusively the presence of one, or more, of some remarkable biophysical-semeiotic constitutions, predisposing to diverse, most common and serious, human disorders. In other words, abnormality of inflammatory response is a “clinical” sign of one (or more) of these constitutions. A long clinical experience allows me to state that the presence of “diabetic”, ”rheumatic”, “dislipidaemic”, “arteriosclerotic”, “hypertensive”, “oncological”, biophysical-semeiotic constitution, either alone or associated with other(s), is always combined with abnormalities of type II hepatic-aspecific gastric reflex (= ungueal pressure upon cutaneous projection area of lever brings about stomach dilation, i.e., gastric aspecific reflex: See above-cited site: Technical Page, N° 1), more or less intense: “basal” lt less than 9 sec. (NN = 10 sec.) which lowers to < 4 sec. (NN = 9-10 sec.) during apnea test, lasting only for 5 sec. and persisting boxer’test: Restano’s manoeuvre. From the above briefly referred data, it follows that body response type to the agents stimulating hepatic APP production, shows a precise genetic component, always correlated with one (or more) particular biophysical- semeiotic constitution, conditio sine qua non of disease onset, e.g., CAD, indicating clearly the real role played by inflammation in arteriosclerosis pathogenesis, that is surely important, but dependent on an outstanding biophysical-semeiotic constitution, which could also be associated to other(s). Therefore, the altered, intense APP synthesis, under a large variety of pathological conditions, is part of a (or more) singular “constitution” , and a sign of it. In conclusion, inflammation plays surely an important and remarkable role in arteriosclerotic disease onset, for example CAD, in many cases, because it is always dependent on patient’s constitution, which defines both seriousness and type of disease.

References 1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm 2) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ediz. Travel Factory, Roma, 2004. 3) Stagnaro S., Stagnaro-Neri M., Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory SRL., Roma, 2004.

Competing interests:   None declared