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Research ArticleOriginal Research

Reimbursement Restriction and Moderate Decrease in Benzodiazepine Use in General Practice

Joëlle M. Hoebert, Patrick C. Souverein, Aukje K. Mantel-Teeuwisse, Hubert G. M. Leufkens and Liset van Dijk
The Annals of Family Medicine January 2012, 10 (1) 42-49; DOI: https://doi.org/10.1370/afm.1319
Joëlle M. Hoebert
PharmD
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Patrick C. Souverein
PhD
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Aukje K. Mantel-Teeuwisse
PhD, PharmD
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Hubert G. M. Leufkens
PhD, PharmD
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Liset van Dijk
PhD
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  • For correspondence: l.vandijk@nivel.nl
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  • Figure 1
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    Figure 1

    Incident diagnoses for anxiety and sleeping disorder in 2008 (■) and 2009 (▵) and their 95% confidence intervals.

  • Figure 2a
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    Figure 2a

    Kaplan-Meier curves for the years 2008 and 2009, illustrating time to discontinuation after initiation of at least 2 benzodiazepine prescriptions in patients with newly diagnosed anxiety.

  • Figure 2b
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    Figure 2b

    Kaplan-Meier curves for the years 2008 and 2009, illustrating time to discontinuation after initiation of at least 2 benzodiazepine prescriptions in patients with newly diagnosed sleeping disorder.

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    Table 1

    Initiation of Benzodiazepine Treatment Among Patients With Incident Diagnoses of Anxiety or Sleeping Disorder

    AnxietySleeping Disorder
    2008200920082009
    CharacteristicDiagnoses No.Benzodiazepine Prescribed No. (%)Diagnoses No.Benzodiazepine Prescribed No. (%)Diagnoses No.Benzodiazepine Prescribed No. (%)Diagnoses No.Benzodiazepine Prescribed No. (%)
    Overall3,7691,270 (33.7)3,7101,116 (30.1)a3,2542,181 (67.0)2,8631,691 (59.1)a
    Sex,
     Men1,205410 (34.0)1,209359 (29.7)a1,171709 (60.5)1,048551 (52.6)a
     Women2,564860 (33.5)2,501757 (30.3)a2,0831,472 (70.7)1,8151,140 (62.8)a
    Age, y,
     18 –441,721419 (24.3)1,716378 (22.0)1,025639 (62.3)836442 (52.9)a
     45–651,418566 (39.9)1,330471 (35.4)a1,399969 (69.3)1,222750 (61.4)a
     66 –75331161 (48.6)358151 (42.2)419296 (70.6)380238 (62.6)a
      >75293124 (42.3)306116 (37.9)411277 (67.4)425261 (61.3)
    • ↵a Statistically significant at P <.05 for 2008 vs 2009.

    • View popup
    Table 2

    Patients With More Than 1 Benzodiazepine Prescription for Newly Diagnosed Anxiety or Sleeping Disorder

    Anxiety, No. (%)Sleeping Disorder, No. (%)
    Characteristic2008200920082009
    Overall541 (42.6)406 (36.4)a930 (42.6)592 (35.0)a
    Sex
     Men181 (44.1)129 (35.9)a289 (40.8)195 (35.4)
     Women360 (41.9)277 (36.6)a641 (43.6)397 (34.8)a
    Age categories
     18–44 y152 (36.3)113 (29.9)218 (34.1)119 (26.9)a
     45–65 y236 (41.7)165 (35.0)a383 (39.5)235 (31.3)a
     66–75 y71 (44.1)69 (45.7)148 (50.0)89 (37.4)a
      >75 y82 (66.1)59 (50.9)a181 (65.3)140 (53.6)a
    • ↵a Statistically significant at P <.05 for 2008 vs 2009.

Additional Files

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  • The Article in Brief

    Reimbursement Restriction and Moderate Decrease in Benzodiazepine Use in General Practice

    Jo�lle M. Hoebert , and colleagues

    Background In 2009, the Netherlands began limiting reimbursement for benzodiazepines to limit misuse and reduce costs. (Benzodiazepines are widely used to treat anxiety, panic disorders and insomnia, as well as in neurologic and rheumatologic conditions.) This study aimes to assess the impact of this reimbursement restriction on benzodiazepine use in patients newly diagnosed with anxiety or sleeping disorders in general practice.

    What This Study Found The policy change restricting benzodiazepine reimbursement led to a moderate decrease in the number of new diagnoses of anxiety and sleeping disorder and a reduction in benzodiazepine prescriptions among patients with newly diagnosed disorders. Analyzing data on 13,596 patients with an incident diagnosis of anxiety or sleeping disorder, researchers found a significantly lower incidence of sleeping disorder diagnoses and anxiety diagnoses after the restriction went into effect. Moreover, the proportion of patients being prescribed a benzodiazepine after a diagnosis was lower in 2009 than in 2008 for both anxiety and sleeping disorder, as was the proportion of patients with more than one benzodiazepine prescription for both anxiety and sleeping disorder. In fact, researchers note, benzodiazepines disappeared from the Netherlands� top 10 most prescribed medications and were among the top 10 medications with the steepest decrease in number of prescriptions. Notably, the authors found no increase in the use of alternative treatment for anxiety using selective serotonin reuptake inhibitors.

    Implications

    • A policy measure can affect drug prescribing.
    • The authors conclude that physicians have room to reduce benzodiazepine prescribing.
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The Annals of Family Medicine: 10 (1)
The Annals of Family Medicine: 10 (1)
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Reimbursement Restriction and Moderate Decrease in Benzodiazepine Use in General Practice
Joëlle M. Hoebert, Patrick C. Souverein, Aukje K. Mantel-Teeuwisse, Hubert G. M. Leufkens, Liset van Dijk
The Annals of Family Medicine Jan 2012, 10 (1) 42-49; DOI: 10.1370/afm.1319

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Reimbursement Restriction and Moderate Decrease in Benzodiazepine Use in General Practice
Joëlle M. Hoebert, Patrick C. Souverein, Aukje K. Mantel-Teeuwisse, Hubert G. M. Leufkens, Liset van Dijk
The Annals of Family Medicine Jan 2012, 10 (1) 42-49; DOI: 10.1370/afm.1319
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