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Research ArticleOriginal Research

Enhanced Communication Skills and C-reactive Protein Point-of-Care Testing for Respiratory Tract Infection: 3.5-year Follow-up of a Cluster Randomized Trial

Jochen W. L. Cals, Leon de Bock, Pieter-Jan H. W. Beckers, Nick A. Francis, Rogier M. Hopstaken, Kerenza Hood, Eefje G. P. M. de Bont, Christopher C. Butler and Geert-Jan Dinant
The Annals of Family Medicine March 2013, 11 (2) 157-164; DOI: https://doi.org/10.1370/afm.1477
Jochen W. L. Cals
1Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, The Netherlands
MDPhD
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  • For correspondence: j.cals@maastrichtuniversity.nl
Leon de Bock
1Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, The Netherlands
MD
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Pieter-Jan H. W. Beckers
1Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, The Netherlands
MD
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Nick A. Francis
2Institute of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff, United Kingdom
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Rogier M. Hopstaken
3Saltro Diagnostic Centre, Utrecht, The Netherlands
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Kerenza Hood
4South East Wales Trials Unit, School of Medicine, Cardiff University, United Kingdom
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Eefje G. P. M. de Bont
1Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, The Netherlands
MD
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Christopher C. Butler
2Institute of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff, United Kingdom
MD
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Geert-Jan Dinant
1Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, The Netherlands
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  • Article
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Article Figures & Data

Figures

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  • Figure 1
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    Figure 1

    Study flowchart.

    CRP = C-reactive protein; GP = general practitioner

Tables

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    • View popup
    Table 1

    Baseline Characteristics of Study Patients and Comparison of Patients Followed up and Lost to Follow-up.

    CharacteristicsPatients in Original Trial
    N = 431
    Patients Available for Follow-up
    n = 379
    Patients Lost to Follow-up n = 52P Valuea
    Women, No. (%)265 (61.5)235 (62.0)30 (57.7).55
    Age, mean (SD), y49.9 (15.3)49.9 (15.0)49.8 (17.6).93
    Comorbidity at index visit, No. (%)
      COPD31 (7.2)24 (6.3)7 (13.5).06
      Asthma39 (9)31 (8.2)8 (15.4).09
    Antibiotics prescribed, No. (%)
      At index visit of trial178 (41.3)160 (42.2)18 (34.6).30
      During 28-day follow-up of trial221 (51.3)197 (52.0)24 (46.2).43

    Note: data in this table represent information recorded during the index visit and 28-day follow-up of the original trial.

    • COPD = chronic obstructive pulmonary disease.

    • ↵a P values come from Mann-Whitney test (age) or χ2 test (other variables) comparing those available for follow-up with those lost to follow-up.

    • View popup
    Table 2

    Characteristics of Patients With Complete Follow-up Data in Intervention and Control Arms

    CharacteristicsCRP Test (n = 203)No CRP Test (n = 176)P ValueaCommunication Skills Training (n = 178)No Communication Skills Training (n = 201)P Valuea
    Women, No. (%)119 (58.6)116 (65.9).15118 (66.3)117 (58.2).11
    Age, mean (SD), y49.4 (14.5)50.4 (15.6).5351.0 (15.3)48.8 (14.6).12
    Comorbidity, No. (%)
      COPD22 (10.8)26 (14.8).2520 (11.2)28 (13.9).43
      Asthma27 (13.3)28 (15.9).4727 (15.2)28 (13.9).73
    Antibiotics prescribed, No. (%)
      At index visit of trial64 (31.5)96 (54.5)<.0149 (27.5)111 (55.2)<.01
      During 28-day follow-up trial92 (45.3)105 (59.7)<.0169 (38.8)128 (63.7)<.01

    Note: for the intervention arm, the family physician performed C-reactive protein testing or had communication skills training.

    • COPD = chronic obstructive pulmonary disease; CRP = C-reactive protein.

    • ↵a P values come from Mann-Whitney test (age) or χ2 test (other variables) comparing intervention group with no intervention group.

    • View popup
    Table 3

    Respiratory Tract Infections During Follow-up in Intervention and Control Arms

    RTI Episodes PPPY
    Control Group Mean No. (95% CI)Intervention Group Mean No. (95% CI)Uncorrected DifferenceCorrected DifferenceaP Valuea
    C-reactive protein test0.56 (0.43–0.68)0.40 (0.33–0.47)−0.16−0.10.12
    Communication skills training0.57 (0.46–0.69)0.36 (0.30–0.42)−0.21−0.11.09

    Note: Intervention included point of care C-reactive protein testing or training in enhanced communication skills.

    • COPD = chronic obstructive pulmonary disease; PPPY = per patient per year; RTI = respiratory tract infection.

    • ↵a P values from multilevel linear regression model to account and correct for variation at level of family physician, and to adjust for both interventions, the number of RTI episodes PPPY during baseline period, COPD comorbidity.

    • View popup
    Table 4

    Percentage of Episodes of Respiratory Tract Infection Treated With Antibiotics During Follow-up in Intervention and Control Arms

    RTI Episodes Treated With Antibiotics
    Control Group % (95% CI)Intervention Group % (95% CI)Uncorrected DifferenceCorrected DifferenceaP Valuea
    C-reactive protein test35.7 (29.5–42.0)30.7 (25.0–36.4)−5.0−4.1.36
    Communication skills training39.1 (33.1–45.1)26.3 (20.6–32.0)−12.8−10.4.02

    Note: intervention included point-of-care C-reactive protein testing or training in enhanced communication skills.

    • ↵a P values from multilevel linear regression model to account and correct for variation at the level of family physician, and to adjust for both interventions, RTI-episodes treated with antibiotics during baseline period, COPD comorbidity.

Additional Files

  • Figures
  • Tables
  • Supplemental Table

    Supplemental Table 1. Comparison Between Baseline and Follow-up Period of Respiratory Tract Infection Episodes per Patient per Year in Intervention and Control Arms

    Files in this Data Supplement:

    • Supplemental data: Table 1 - PDF file, 1 page, 172 KB
  • The Article in Brief

    Enhanced Communication Skills and C-Reactive Protein Point-of-Care Testing for Respiratory Tract Infection: 3.5-Year Follow-up of a Cluster Randomized Trial

    Jochen W. L. Cals , and colleagues

    Background Reducing overprescribing of antibiotics for respiratory tract infections (RTIs) is essential in an era of increasing antimicrobial resistance. This study assesses the long-term effects of 2 interventions on office visit rates and antibiotic prescribing for patients with RTIs; the interventions are family physicians' use of C-reactive protein point-of-care testing, a widely used means of diagnosing and monitoring infections, and physician training in communication skills.

    What This Study Found The study found mixed results. An office visit with a family physician who used C-reactive protein point-of-care testing and/or who was trained in enhanced communication skills had no effect on the rate of office visits for respiratory tract infection episodes during the next 3.5 years. However, patients managed by a family physician trained in enhanced communication skills were less likely to receive antibiotics for RTI episodes during the 3.5-year follow-up. Specifically, family physicians trained in communication skills treated 26 percent of all episodes of respiratory tract infection with antibiotics compared with 39 percent treated by family physicians without such training. The cluster-randomized controlled trial included 379 patients at 20 family practices in the Netherlands.

    Implications

    • The authors call for implementation of both interventions on a larger scale, noting that training physicians in the use of enhanced communication skills may have a wider longer-term effect on the treatment of respiratory tract infections beyond acute cough to include reduced antibiotic prescribing.
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The Annals of Family Medicine: 11 (2)
The Annals of Family Medicine: 11 (2)
Vol. 11, Issue 2
March/April 2013
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Enhanced Communication Skills and C-reactive Protein Point-of-Care Testing for Respiratory Tract Infection: 3.5-year Follow-up of a Cluster Randomized Trial
Jochen W. L. Cals, Leon de Bock, Pieter-Jan H. W. Beckers, Nick A. Francis, Rogier M. Hopstaken, Kerenza Hood, Eefje G. P. M. de Bont, Christopher C. Butler, Geert-Jan Dinant
The Annals of Family Medicine Mar 2013, 11 (2) 157-164; DOI: 10.1370/afm.1477

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Enhanced Communication Skills and C-reactive Protein Point-of-Care Testing for Respiratory Tract Infection: 3.5-year Follow-up of a Cluster Randomized Trial
Jochen W. L. Cals, Leon de Bock, Pieter-Jan H. W. Beckers, Nick A. Francis, Rogier M. Hopstaken, Kerenza Hood, Eefje G. P. M. de Bont, Christopher C. Butler, Geert-Jan Dinant
The Annals of Family Medicine Mar 2013, 11 (2) 157-164; DOI: 10.1370/afm.1477
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  • Implementation of C-reactive protein point of care testing to improve antibiotic targeting in respiratory illness in Vietnamese primary care (ICAT): a study protocol for a cluster randomised controlled trial
  • Antibiotic Prescribing for Acute Respiratory Tract Infections 12 Months After Communication and CRP Training: A Randomized Trial
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  • Advances in optimizing the prescription of antibiotics in outpatient settings
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Keywords

  • respiratory tract infection
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  • antibiotics
  • communication
  • family practice

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