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Research ArticleOriginal Research

Cannabis and Young Users—A Brief Intervention to Reduce Their Consumption (CANABIC): A Cluster Randomized Controlled Trial in Primary Care

Catherine Laporte, Hélène Vaillant-Roussel, Bruno Pereira, Olivier Blanc, Bénédicte Eschalier, Shérazade Kinouani, Georges Brousse, Pierre-Michel Llorca and Philippe Vorilhon
The Annals of Family Medicine March 2017, 15 (2) 131-139; DOI: https://doi.org/10.1370/afm.2003
Catherine Laporte
1Univ Clermont 1, UFR Medicine, Department of General Practice, Clermont-Ferrand, F-63001, France
2Univ Clermont 1, UFR Medicine, EA7280, Clermont-Ferrand, F-63001, France
MD, PhD
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  • For correspondence: Catherine.laporte@udamail.fr
Hélène Vaillant-Roussel
1Univ Clermont 1, UFR Medicine, Department of General Practice, Clermont-Ferrand, F-63001, France
3CHU Clermont-Ferrand, Clinical Pharmacology Departement - Clinical Investigation Centre (Inserm CIC 501), Clermont-Ferrand, F-63003, France
MD, PhD
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Bruno Pereira
4CHU Clermont-Ferrand, Office for Clinical research and Innovation, Clermont-Ferrand, F-63003, France
PhD
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Olivier Blanc
1Univ Clermont 1, UFR Medicine, Department of General Practice, Clermont-Ferrand, F-63001, France
5CHU Clermont-Ferrand, Psychiatry B, Clermont-Ferrand, F-63003, France
MSc
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Bénédicte Eschalier
1Univ Clermont 1, UFR Medicine, Department of General Practice, Clermont-Ferrand, F-63001, France
MD
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Shérazade Kinouani
6Univ Bordeaux, UFR Medicine, Department of General Practice, Bordeaux, F-33076, France
MD
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Georges Brousse
2Univ Clermont 1, UFR Medicine, EA7280, Clermont-Ferrand, F-63001, France
5CHU Clermont-Ferrand, Psychiatry B, Clermont-Ferrand, F-63003, France
MD, PhD
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Pierre-Michel Llorca
2Univ Clermont 1, UFR Medicine, EA7280, Clermont-Ferrand, F-63001, France
5CHU Clermont-Ferrand, Psychiatry B, Clermont-Ferrand, F-63003, France
MD, PhD
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Philippe Vorilhon
1Univ Clermont 1, UFR Medicine, Department of General Practice, Clermont-Ferrand, F-63001, France
7Univ Clermont 1, UFR Medecine, EA4681, Clermont-Ferrand, F-63001, France
MD
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  • Figure 1
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    Figure 1

    Flowchart of general practitioners and patients.

    Note: Following Consolidated Standard Reporting Trials (Consort) 2010 flow diagram.

  • Figure 2
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    Figure 2

    Median number of joints smoked per month at baseline and at 3, 6, and 12 months.

    aValues are median number of joints smoked per month (interquartile range).

  • Figure 3
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    Figure 3

    Median number of joints smoked per month at baseline and at 3, 6, and 12 months, according to age-group.

    aValues are median number of joints smoked per month (interquartile range).

Tables

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    Table 1

    Characteristics of General Practitioners and Patients

    CharacteristicOverallGroup P Value
    InterventionControl
    General practitioners, No.  77  40  37
    Men, No. (%)  42 (54.6)  23 (57.5)  19 (51.3).59
    Age, mean (SD), y  48.3 (9.2)  47.8 (9.0)  48.9 (9.5).60
    Group practice, No. (%)a  51 (66.2)  27 (67.5)  24 (64.9).81
    Self-employed, No. (%)  65 (85.5)  32 (82.1)  33 (89.2).38
    Teaching role, No. (%)b  32 (41.6)  18 (45.0)  14 (37.9).52
    Work setting
     Rural, No. (%) 9 (11.7) 4 (10.0) 5 (13.5).73
     Semirural, No. (%)  37 (48.0)  18 (45.0)  19 (51.4)
     Urban, No. (%)  31 (40.3)  18 (45.0)  13 (35.1)
    Number of patients enrolled, mean (SD) 3.4 (2.1) 3.5 (2.2) 3.3 (2.0).60
    Patients, No.262141121
    Men, No. (%)169 (64.5)  89 (63.1)  80 (66.1).61
    Age
     Mean (SD), y  20.60 (2.6)  20.88 (2.7)  20.28 (2.6).07
     <18 y, No. (%)  47 (18.0)  20 (14.3)  27 (22.3).09
    Marital status, No. (%)
     Single211 (81.2)108 (77.7)103 (84.3).31
     Married  49 (18.9)  31 (22.3)  18 (14.9)
     Divorced/separated 2 (0.8) 1 (0.7) 1 (0.9)
    Lodging status, No. (%)
     Cohabiting202 (77.1)106 (75.2) 96 (79.3).42
     Living alone  63 (24.1)  37 (26.2)  26 (21.5).37
    Employment status, No. (%)
     Working147 (56.1) 82 (58.2) 65 (53.7).07
     No occupation 7 (2.7) 5 (3.6) 2 (1.7)
     Student108 (41.2)  54 (38.3)  54 (44.6)
    Psychotropic medication use, No. (%)c  10 (3.8) 6 (4.3) 4 (3.3).69
    Cannabis use
     Joints per mo, median (IQR)  20 (6–60)  30 (6–80)  20 (5–40).08
     ≥30 joints per mo, No. (%)121 (46.2)  73 (51.8)  48 (39.7).05
     Use bongs, No. (%)  39 (14.9)  27 (19.2)  12 (9.9).04
     Age at first use, mean (SD), y  15.15 (1.9)  15.24 (2.1)  15.04 (1.6).40
    Alcohol use
     Used in past month, No. (%)204 (77.9)110 (78.0)  94 (77.7).94
     Quantity: glasses/wk, median (IQR) 6 (2–10) 5 (2–10)  7.5 (3–14).02
    Tobacco use
     Used in past month, No. (%)240 (91.6)124 (87.9)116 (95.7).02
     Quantity: cigarettes/wk, median (IQR)  60 (30–82)  60 (35–100)  60 (28–78).60
    Experimented with other drugs, No. (%)111 (42.4)  59 (41.8)  52 (43.0).85
    • IQR = interquartile range.

    • ↵a Any practice other than solo practice.

    • ↵b Taught students in his or her practice.

    • ↵c Anxiolytics prescribed by the general practitioner.

    • View popup
    Table 2

    Comparison of Intervention and Control Groups According to Frequency of Cannabis Use at Baseline

    Time PointNondaily UsersaDaily Usersb
    InterventionControlP ValueInterventionControlP Value
    Baseline6 (4–14)10 (4–15).29  70 (40–120)50 (30–95).11
    3 months4 (2–20)10 (5–21).1940 (20–95)35 (10–60).41
    6 months5 (1–10)10 (5–20)  .002  40 (23–100)30 (10–68).17
    12 months3 (0–15)10 (3–30).01  55 (10–100)30 (15–60).40
    • Note: Values are median number of joints smoked per month (interquartile range).

    • ↵a Smoked <30 joints per month at baseline.

    • ↵b Smoked ≥30 joints per month at baseline.

Additional Files

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  • The Article in Brief

    Cannabis and Young Users-A Brief Intervention to Reduce Their Consumption (CANABIC): Findings of a Cluster Randomized Controlled Trial

    Catherine Laporte , and colleagues

    Background There have been few studies of brief primary care interventions for cannabis use by young people. This study examines whether a brief primary care intervention for young cannabis users leads to a decrease in consumption, regardless of their initial consumption level.

    What This Study Found A brief motivational interview following the FRAMES (feedback, responsibility, advice, menu, empathy and self-efficacy) model shows some effectiveness for users aged under 18 years and for moderate nondaily users, but no effect in the study population overall. Specifically, after one year, there was no significant difference between the intervention and control groups in the number of joints smoked per month among all users, but there was a difference in favor of the intervention among nondaily users. After six months, the intervention was associated with more favorable change from baseline in the number of joints smoked and among users aged younger than 18 years, smoking fewer joints per month.

    Implications

    • The authors conclude that these findings support the use of a brief intervention in primary care for younger users and moderate users.
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The Annals of Family Medicine: 15 (2)
The Annals of Family Medicine: 15 (2)
Vol. 15, Issue 2
March/April 2017
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Cannabis and Young Users—A Brief Intervention to Reduce Their Consumption (CANABIC): A Cluster Randomized Controlled Trial in Primary Care
Catherine Laporte, Hélène Vaillant-Roussel, Bruno Pereira, Olivier Blanc, Bénédicte Eschalier, Shérazade Kinouani, Georges Brousse, Pierre-Michel Llorca, Philippe Vorilhon
The Annals of Family Medicine Mar 2017, 15 (2) 131-139; DOI: 10.1370/afm.2003

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Cannabis and Young Users—A Brief Intervention to Reduce Their Consumption (CANABIC): A Cluster Randomized Controlled Trial in Primary Care
Catherine Laporte, Hélène Vaillant-Roussel, Bruno Pereira, Olivier Blanc, Bénédicte Eschalier, Shérazade Kinouani, Georges Brousse, Pierre-Michel Llorca, Philippe Vorilhon
The Annals of Family Medicine Mar 2017, 15 (2) 131-139; DOI: 10.1370/afm.2003
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