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Research ArticleOriginal Research

Premature Death Among Primary Care Patients With a History of Self-Harm

Matthew J. Carr, Darren M. Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur and Roger T. Webb
The Annals of Family Medicine May 2017, 15 (3) 246-254; DOI: https://doi.org/10.1370/afm.2054
Matthew J. Carr
Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Carr, While, Awenat, Cooper, Kapur, Webb); Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Ashcroft); NIHR Greater Manchester Primary Care Patient Safety Translational Research Centre, Manchester M13 9PL, UK (Ashcroft); Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Kontopantelis); Research Institute of Primary Care and Health Sciences, Keele University, Staffordshire ST5 5BG, UK (Chew-Graham); West Midlands NIHR Collaborative Leadership in Applied Health Research and Care (CLAHRC), Birmingham, UK (Chew-Graham).
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  • For correspondence: matthew.carr@manchester.ac.uk
Darren M. Ashcroft
Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Carr, While, Awenat, Cooper, Kapur, Webb); Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Ashcroft); NIHR Greater Manchester Primary Care Patient Safety Translational Research Centre, Manchester M13 9PL, UK (Ashcroft); Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Kontopantelis); Research Institute of Primary Care and Health Sciences, Keele University, Staffordshire ST5 5BG, UK (Chew-Graham); West Midlands NIHR Collaborative Leadership in Applied Health Research and Care (CLAHRC), Birmingham, UK (Chew-Graham).
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Evangelos Kontopantelis
Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Carr, While, Awenat, Cooper, Kapur, Webb); Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Ashcroft); NIHR Greater Manchester Primary Care Patient Safety Translational Research Centre, Manchester M13 9PL, UK (Ashcroft); Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Kontopantelis); Research Institute of Primary Care and Health Sciences, Keele University, Staffordshire ST5 5BG, UK (Chew-Graham); West Midlands NIHR Collaborative Leadership in Applied Health Research and Care (CLAHRC), Birmingham, UK (Chew-Graham).
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David While
Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Carr, While, Awenat, Cooper, Kapur, Webb); Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Ashcroft); NIHR Greater Manchester Primary Care Patient Safety Translational Research Centre, Manchester M13 9PL, UK (Ashcroft); Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Kontopantelis); Research Institute of Primary Care and Health Sciences, Keele University, Staffordshire ST5 5BG, UK (Chew-Graham); West Midlands NIHR Collaborative Leadership in Applied Health Research and Care (CLAHRC), Birmingham, UK (Chew-Graham).
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Yvonne Awenat
Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Carr, While, Awenat, Cooper, Kapur, Webb); Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Ashcroft); NIHR Greater Manchester Primary Care Patient Safety Translational Research Centre, Manchester M13 9PL, UK (Ashcroft); Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Kontopantelis); Research Institute of Primary Care and Health Sciences, Keele University, Staffordshire ST5 5BG, UK (Chew-Graham); West Midlands NIHR Collaborative Leadership in Applied Health Research and Care (CLAHRC), Birmingham, UK (Chew-Graham).
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Jayne Cooper
Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Carr, While, Awenat, Cooper, Kapur, Webb); Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Ashcroft); NIHR Greater Manchester Primary Care Patient Safety Translational Research Centre, Manchester M13 9PL, UK (Ashcroft); Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Kontopantelis); Research Institute of Primary Care and Health Sciences, Keele University, Staffordshire ST5 5BG, UK (Chew-Graham); West Midlands NIHR Collaborative Leadership in Applied Health Research and Care (CLAHRC), Birmingham, UK (Chew-Graham).
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Carolyn Chew-Graham
Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Carr, While, Awenat, Cooper, Kapur, Webb); Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Ashcroft); NIHR Greater Manchester Primary Care Patient Safety Translational Research Centre, Manchester M13 9PL, UK (Ashcroft); Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Kontopantelis); Research Institute of Primary Care and Health Sciences, Keele University, Staffordshire ST5 5BG, UK (Chew-Graham); West Midlands NIHR Collaborative Leadership in Applied Health Research and Care (CLAHRC), Birmingham, UK (Chew-Graham).
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Nav Kapur
Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Carr, While, Awenat, Cooper, Kapur, Webb); Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Ashcroft); NIHR Greater Manchester Primary Care Patient Safety Translational Research Centre, Manchester M13 9PL, UK (Ashcroft); Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Kontopantelis); Research Institute of Primary Care and Health Sciences, Keele University, Staffordshire ST5 5BG, UK (Chew-Graham); West Midlands NIHR Collaborative Leadership in Applied Health Research and Care (CLAHRC), Birmingham, UK (Chew-Graham).
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Roger T. Webb
Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Carr, While, Awenat, Cooper, Kapur, Webb); Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Ashcroft); NIHR Greater Manchester Primary Care Patient Safety Translational Research Centre, Manchester M13 9PL, UK (Ashcroft); Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK (Kontopantelis); Research Institute of Primary Care and Health Sciences, Keele University, Staffordshire ST5 5BG, UK (Chew-Graham); West Midlands NIHR Collaborative Leadership in Applied Health Research and Care (CLAHRC), Birmingham, UK (Chew-Graham).
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    Figure 1

    Hazard ratios for death due to various causes, stratified by individual follow-up year.

    Notes: Hazard ratios for self-harm cohort vs comparison cohort. Note that y-axis scales differ. Dark gray line indicates modeled 2-stage trend. Light gray line indicates unity (1).

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    Table 1

    Sociodemographic Characteristics at Index Self-Harm Episode

    CharacteristicSelf-Harm Cohort, No. (%) (n = 30,017)Comparison Cohort, No. (%) (n = 600,258)
    Sex
     Male12,390 (41.3)247,746 (41.3)
     Female17,627 (58.7)352,512 (58.7)
    Age-group, y
     15–2411,876 (39.6)237,470 (39.6)
     25–346,028 (20.1)120,541 (20.1)
     35–446,132 (20.4)122,665 (20.4)
     45–543,995 (13.3)79,869 (13.3)
     55–641,986 (6.6)39,696 (6.6)
    Index of Multiple Deprivation
     Quintile 1 (least deprived)3,359 (11.2)67,174 (11.2)
     Quintile 26,023 (20.1)120,452 (20.1)
     Quintile 35,571 (18.6)111,412 (18.6)
     Quintile 47,305 (24.3)146,079 (24.3)
     Quintile 5 (most deprived)7,759 (25.9)155,141 (25.9)
    • View popup
    Table 2

    Clinical Characteristics at Index Self-Harm Episode

    CharacteristicSelf-Harm Cohort, No. (%) (n = 30,017)Comparison Cohort, No. (%) (n = 600,258)
    General practitioner visits in past 12 mo
     0 visits2,395 (8.0)152,795 (25.5)
     1–2 visits5,217 (17.4)168,467 (28.1)
     3–5 visits6,935 (23.1)143,100 (23.8)
     ≥6 visits15,470 (51.5)135,896 (22.6)
    Mental health history
     Psychiatric diagnosis16,513 (55.0)126,301 (21.0)
     Referral to mental health services8,506 (28.3)39,653 (6.6)
     Psychotropic drug prescribed20,377 (67.9)191,874 (32.0)
     Alcohol misuse2,069 (6.9)4,352 (0.7)
    Physical health history
     Asthma5,860 (19.5)91,830 (15.3)
     Cancer308 (1.0)4,854 (0.8)
     Coronary heart disease348 (1.2)3,729 (0.6)
     Chronic kidney disease114 (0.4)1,400 (0.2)
     Chronic obstructive pulmonary disease193 (0.6)1,453 (0.2)
     Diabetes849 (2.8)8,896 (1.5)
     Hypertension1,455 (4.8)23,653 (3.9)
     Stroke202 (0.7)1,400 (0.2)
    Smoking status
     Never smoked9,545 (36.7)286,547 (58.9)
     Current smoker13,507 (52.0)134,538 (27.7)
     Ex-smoker2,936 (11.3)65,306 (13.4)
     Unknown4,029 (−)113,867 (−)
    • View popup
    Table 3

    Hazard Ratios for Deaths Due to All Causes, All Natural Causes, and All Unnatural Causes

    Cause of DeathbFollow-up PeriodSelf-Harm CohortHazard Ratioa (95% CI)
    Deaths, No.% per 1,000 Person-YearsUnadjustedAdjustedc
    All causes≤1 y30111.19.92 (8.63–11.40)3.59 (3.08–4.19)
    >1 y6736.33.92 (3.61–4.27)1.70 (1.54–1.88)
    All natural causes≤1 y1264.64.79 (3.94–5.82)1.51 (1.11–1.87)
    >1 y4594.32.98 (2.69–3.29)1.25 (1.11–1.40)
    All unnatural causes≤1 y1756.443.31 (33.20–56.49)21.11 (15.83–28.15)
    >1 y2142.012.53 (10.48–14.99)5.65 (4.60–6.94)
    • ↵a Two-stage hazard ratios for the self-harm cohort vs the comparison cohort.

    • ↵b Deaths were delineated using International Classification of Diseases 10th Revision (ICD-10) codes: unnatural death, codes V01-Y98; natural death, any code other than V01-Y98.

    • ↵c Adjusted for visit frequency in previous 12 months, history of psychiatric diagnoses, history of mental health referral, history of psychotropic medication prescribing, history of alcohol misuse, and smoking status.

    • View popup
    Table 4

    Hazard Ratios for Deaths Due to Specific Causes

    Cause of DeathbFollow-up PeriodSelf-Harm CohortHazard Ratioa (95% CI)
    Deaths, No.% per 1,000 Person-YearsUnadjustedAdjustedc
    Suicide≤1 y1405.1113.90 (73.87–175.63)54.43 (34.32–86.32)
    >1 y1221.117.45 (13.50–22.54)7.62 (5.67–10.25)
    Accident≤1 y351.312.94 (8.45–19.84)5.60 (3.45–9.08)
    >1 y900.89.32 (7.19–12.08)4.16 (3.05–5.65)
    Alcohol related≤1 y261.014.52 (8.74–24.11)2.62 (1.14–6.02)
    >1 y1061.011.16 (8.72–14.29)2.37 (1.50–3.76)
    Drug poisoning≤1 y491.848.17 (28.63–81.03)17.62 (9.83–31.58)
    >1 y910.828.46 (20.25–39.98)9.22 (6.14–13.83)
    Respiratory disease≤1 y110.46.39 (3.24–12.61)2.64 (1.22–5.70)
    >1 y530.54.94 (3.63–6.72)2.21 (1.55–3.15)
    Lung cancer≤1 y90.34.55 (2.20–9.39)2.31 (1.00–5.30)
    >1 y290.31.92 (1.31–2.82)0.88 (0.56–1.37)
    • ↵a Two-stage hazard ratios for the self-harm cohort vs the comparison cohort.

    • ↵b Causes of death delineated using the following International Classification of Diseases 10th Revision (ICD-10) codes: suicide: X60–X84, Y10–Y34 (excluding Y33.9), Y87.0, Y87.2; accident: V01-X59, Y85–Y86, Y87.1; alcohol related: F10, G31.1, I42.6, K29.2, K70, K73, K74 (excluding K74.3–K74.5), K86.0, X45, X65, Y15; drug poisoning: F11–F16, F18–F19, X40–X44, X60–X64, X85, Y10–Y14; respiratory disease: J00–J99; lung cancer: C33–C34.

    • ↵c Adjusted for visit frequency in previous 12 months, history of psychiatric diagnoses, history of mental health referral, history of psychotropic medication prescribing, history of alcohol misuse, and smoking status.

    • View popup
    Table 5

    Cumulative Incidence of Deaths Due to All Causes and Specific Causes

    Cause of DeathaSelf-Harm Cohort (n = 30,017)Comparison Cohort (n = 600,258)
    Deaths, No.Cumulative Incidence, % (95% CI)Deaths, No.Cumulative Incidence, % (95% CI)
    All causes
     At 1 y3011.07 (0.96–1.20)6340.11 (0.10–0.12)
     At 5 y7393.47 (3.22–3.73)2,7770.68 (0.66–0.71)
     At 10 y9466.53 (6.04–7.06)4,4551.79 (1.73–1.85)
    All natural causes
     At 1 y1260.46 (0.38–0.54)5510.10 (0.09–0.11)
     At 5 y4062.01 (1.82–2.22)2,4350.60 (0.58–0.63)
     At 10 y5634.43 (4.00–4.90)3,9891.63 (1.57–1.69)
    All unnatural causes
     At 1 y1750.62 (0.53–0.72)830.01 (0.01–0.02)
     At 5 y3331.49 (1.33–1.66)3420.08 (0.07–0.09)
     At 10 y3832.21 (1.95–2.49)4660.16 (0.15–0.18)
    Suicide
     At 1 y1400.50 (0.42–0.58)270.00 (0.00–0.01)
     At 5 y2341.00 (0.88–1.14)1310.03 (0.03–0.04)
     At 10 y2581.33 (1.15–1.53)1820.07 (0.06–0.08)
    Accidental
     At 1 y350.12 (0.09–0.17)540.01 (0.01–0.01)
     At 5 y970.48 (0.39–0.59)2010.05 (0.04–0.05)
     At 10 y1230.88 (0.70–1.09)2730.09 (0.08–0.11)
    Alcohol related
     At 1 y260.09 (0.06–0.14)400.01 (0.01–0.01)
     At 5 y940.48 (0.39–0.59)1650.04 (0.03–0.05)
     At 10 y1321.03 (0.84–1.27)2600.10 (0.09–0.12)
    Drug poisoning
     At 1 y490.17 (0.13–0.23)200.00 (0.00–0.01)
     At 5 y1160.54 (0.45–0.65)730.02 (0.01–0.02)
     At 10 y1380.86 (0.70–1.06)900.03 (0.02–0.03)
    • ↵a Causes delineated as indicated in Table 3 and Table 4 footnotes.

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  • The Article in Brief

    Premature Death Among Primary Care Patients With a History of Self-Harm

    Matthew J. Carr , and colleagues

    Background Self-harm is a major public health problem. This study investigates risk of dying prematurely from any cause after self-harm.

    What This Study Found Primary care patients who have harmed themselves are at greatly increased risk of dying prematurely by natural and unnatural causes, especially within a year of a self-harm episode. Among 30,017 patients aged 15 to 64 years, there was an elevated risk of dying prematurely from any cause among the self-harm group, especially in the first year of follow-up. In particular, suicide risk was especially high in the first year. Although it declined sharply after one year, it remained much higher than in the comparison group. During the 10-year follow-up period there were also large increases in risk for accidental, alcohol-related and drug-poisoning deaths.

    Implications

    • The authors point out that patients with a history of self-harm visit clinicians at a relatively high frequency, which presents a clear opportunity for preventive action. They call for national guidelines that provide more specific recommendations and training on how primary care teams can more effectively intervene, manage, and monitor risk in these patients.
  • Supplemental Appendixes

    Supplemental Appendixes

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The Annals of Family Medicine: 15 (3)
The Annals of Family Medicine: 15 (3)
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Premature Death Among Primary Care Patients With a History of Self-Harm
Matthew J. Carr, Darren M. Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T. Webb
The Annals of Family Medicine May 2017, 15 (3) 246-254; DOI: 10.1370/afm.2054

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Premature Death Among Primary Care Patients With a History of Self-Harm
Matthew J. Carr, Darren M. Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T. Webb
The Annals of Family Medicine May 2017, 15 (3) 246-254; DOI: 10.1370/afm.2054
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