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Research ArticleOriginal Research

Associations of Subjective Memory Complaints and Simple Memory Task Scores With Future Dementia in the Primary Care Setting

Lennard L. van Wanrooij, Edo Richard, Susan Jongstra, Eric P. Moll van Charante and Willem A. van Gool
The Annals of Family Medicine September 2019, 17 (5) 412-418; DOI: https://doi.org/10.1370/afm.2443
Lennard L. van Wanrooij
1Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam, The Netherlands
MSc
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  • For correspondence: l.l.vanwanrooij@amc.uva.nl
Edo Richard
2Donders Institute of Brain, Cognition, and Behavior, Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands
MD, PhD
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Susan Jongstra
1Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam, The Netherlands
MD, PhD
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Eric P. Moll van Charante
3Amsterdam UMC, University of Amsterdam, Department of Family Medicine, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
MD, PhD
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Willem A. van Gool
1Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam, The Netherlands
MD
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Article Figures & Data

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  • Figure 1
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    Figure 1

    Tree graph of incident dementia rates for SMC in combination with MMSE delayed recall item scores and VAT scores.

    MMSE = Mini-Mental State Examination, item 5 (delayed recall); SMC = subjective memory complaints; VAT = Visual Association Test.

    Note: Data are presented as mean (95% CI).

  • Figure 2
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    Figure 2

    Kaplan-Meier curves for dichotomized MMSE-5 and VAT scores, for participants with and without SMC.

    MMSE-5 = Mini-Mental State Examination, item 5 (delayed recall); SMC = subjective memory complaints; VAT = Visual Association Test.

Tables

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    Table 1

    Baseline Patient Characteristics

    CharacteristicNo Dementia at Follow-up (n = 3,221)Dementia at Follow-up (n = 233)
    Mean age, y (SD; IQR)74.3 (2.5; 72-76)75.1 (2.6; 73-77)
    Female, No. (%)1,752 (54)133 (57)
    Educational level, No. (%)a
     Low: <7 y748 (23)74 (32)
     Intermediate: 7-12 y2,007 (63)133 (58)
     High: >12 y436 (14)22 (10)
    Subjective memory complaints, No. (%)b515 (16)86 (37)
    MMSE-5 imperfect, No. (%)c1,876 (58)174 (75)
    VAT imperfect, No. (%)d858 (27)124 (54)
    • IQR = interquartile range; MMSE-5 = Mini-Mental State Examination, item 5 (delayed recall); VAT = Visual Association Test.

    • ↵a 34 missing (30 in no dementia group, 4 in dementia group).

    • ↵b 31 missing, based on Geriatric Depression Scale 15, item 10 (30 in no dementia group, 1 in dementia group).

    • ↵c 1 missing (in no dementia group).

    • ↵d 18 missing (15 in no dementia group, 3 in dementia group).

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    Table 2

    Dementia Risk in Relation to SMC and Scores on the MMSE-5 and VAT

    VariableNo. Dementia Cases/No. at Risk (%)HR (95% CI)P ValueAdjusted HR (95% CI)aP Value
    No SMC146/2,822 (5)1 (reference)
    SMC86/601 (14)3.01 (2.31-3.94)<.0012.97 (2.27-3.9)<.001
    Optimal MMSE-5 (3 points)59/1,403 (4)1 (reference)
    Imperfect MMSE-5 (<3 points)174/2,050 (8)2.14 (1.59-2.87)<.0011.98 (1.47-2.67).007
    Optimal VAT (6 points)106/2,454 (4)1 (reference)
    Imperfect VAT (<6 points)124/982 (13)3.19 (2.46-4.13)<.0013.04 (2.33-3.95)<.001
    • HR = hazard ratio; MMSE-5 = Mini-Mental State Examination, item 5 (delayed recall); SMC = subjective memory complaints; VAT = Visual Association Test.

    • ↵a Adjusted for age and educational level.

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    Table 3

    Dementia Risk in Relation to SMC in Combination With Either the MMSE-5 or VAT

    VariableNo. of Dementia Cases/No. at Risk (%)HR (95% CI)P ValueAdjusted HR (95% CI)aP Value
    No SMC and optimal MMSE-5b48/1,176 (4)1 (reference)
    No SMC and imperfect MMSE-598/1,645 (6)1.52 (1.08-2.15).0171.41 (1.0-2.0).056
    SMC and optimal MMSE-511/210 (5)1.33 (0.69-2.56).3941.32 (0.69-2.55).401
    SMC and imperfect MMSE-575/391 (19)5.48 (3.82-7.88)<.0015.06 (3.5-7.3)<.001
    No SMC and optimal VATc77/2,060 (4)1 (reference)
    No SMC and imperfect VAT68/749 (9)2.62 (1.89-3.63)<.0012.56 (1.84-3.57)<.001
    SMC and optimal VAT29/373 (8)2.25 (1.45-3.45)<.0012.33 (1.52-3.58)<.001
    SMC and imperfect VAT55/223 (25)7.74 (5.47-10.94)<.0017.15 (5.01-10.19)<.001
    • HR = hazard ratio; MMSE-5 = Mini-Mental State Examination, item 5 (delayed recall); SMC = subjective memory complaints; VAT = Visual Association Test.

    • ↵a Adjusted for age and educational level.

    • ↵b For 32 participants, SMC, MMSE-5, or both, was missing.

    • c For 49 participants, SMC, VAT, or both, was missing.

Additional Files

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    • Supplemental data: Appendixes - PDF file
  • The Article in Brief

    Associations of Subjective Memory Complaints and Simple Memory Task Scores With Future Dementia in the Primary Care Setting

    Lennard L. van Wanrooij , and colleagues

    Background Primary care physicians rely on a battery of instruments to assess the risk of dementia in older patients. The combination of screening tools must be simple enough to fit within a regular primary care visit, while being comprehensive enough to distinguish patients in need of referral to specialist memory care.

    What This Study Found Analysis of data from a longitudinal cluster-randomized controlled trial of 3,526 adults aged 70 to 78 showed that assessment of dementia risk using three common screening tools at baseline predicts incident dementia over the course of about seven years. A single screening question to assess subjective memory loss was associated with future dementia. Furthermore, participants who showed subjective memory loss, who then reached a threshold score on two cognitive function instrument--the Visual Association Test and the delayed recall item of the Mini-Mental State Examination (item 5--showed rates of dementia up to 30% at follow-up. The authors recommend starting with the single question on subjective memory loss, followed by a brief assessment of cognitive delay from the MMSE-5 and then the VAT.

    Implications

    • The findings of this study suggest that assessing subjective memory loss using a single question chosen from the 15-item Geriatric Depression Scale, in combination with the MMSE delayed recall item and the VAT, may be a promising way to assess dementia risk in primary care.
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The Annals of Family Medicine: 17 (5)
The Annals of Family Medicine: 17 (5)
Vol. 17, Issue 5
September/October 2019
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Associations of Subjective Memory Complaints and Simple Memory Task Scores With Future Dementia in the Primary Care Setting
Lennard L. van Wanrooij, Edo Richard, Susan Jongstra, Eric P. Moll van Charante, Willem A. van Gool
The Annals of Family Medicine Sep 2019, 17 (5) 412-418; DOI: 10.1370/afm.2443

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Associations of Subjective Memory Complaints and Simple Memory Task Scores With Future Dementia in the Primary Care Setting
Lennard L. van Wanrooij, Edo Richard, Susan Jongstra, Eric P. Moll van Charante, Willem A. van Gool
The Annals of Family Medicine Sep 2019, 17 (5) 412-418; DOI: 10.1370/afm.2443
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Subjects

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