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Review ArticleSystematic Review

Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis

Mark H. Ebell, Henry C. Barry, Kanishka Baduni and Gabrielle Grasso
The Annals of Family Medicine January 2024, 22 (1) 50-62; DOI: https://doi.org/10.1370/afm.3050
Mark H. Ebell
1Department of Epidemiology and Biostatistics, College of Public Health, the University of Georgia, Athens, Georgia
MD, MS
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  • For correspondence: ebell@uga.edu
Henry C. Barry
2Department of Family Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan
MD, MS
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Kanishka Baduni
3Department of Kinesiology, College of Education, the University of Georgia, Athens, Georgia
MPT
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Gabrielle Grasso
1Department of Epidemiology and Biostatistics, College of Public Health, the University of Georgia, Athens, Georgia
MPH
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Article Information

vol. 22 no. 1 50-62
DOI 
https://doi.org/10.1370/afm.3050
PubMed 
38253509

Published By 
The Annals of Family Medicine
Print ISSN 
1544-1709
Online ISSN 
1544-1717
History 
  • Received for publication May 4, 2023
  • Revision received September 20, 2023
  • Accepted for publication September 21, 2023
  • Published online January 22, 2024.

Copyright & Usage 
© 2024 Annals of Family Medicine, Inc.

Author Information

  1. Mark H. Ebell, MD, MS1⇑,
  2. Henry C. Barry, MD, MS2,
  3. Kanishka Baduni, MPT3 and
  4. Gabrielle Grasso, MPH1
  1. 1Department of Epidemiology and Biostatistics, College of Public Health, the University of Georgia, Athens, Georgia
  2. 2Department of Family Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan
  3. 3Department of Kinesiology, College of Education, the University of Georgia, Athens, Georgia
  1. CORRESPONDING AUTHOR Mark H. Ebell, UGA Health Sciences Campus, University of Georgia, 125 B.S. Miller Hall, Athens, GA 30602, ebell{at}uga.edu

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Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis
Mark H. Ebell, Henry C. Barry, Kanishka Baduni, Gabrielle Grasso
The Annals of Family Medicine Jan 2024, 22 (1) 50-62; DOI: 10.1370/afm.3050

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Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis
Mark H. Ebell, Henry C. Barry, Kanishka Baduni, Gabrielle Grasso
The Annals of Family Medicine Jan 2024, 22 (1) 50-62; DOI: 10.1370/afm.3050
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Subjects

  • Domains of illness & health:
    • Chronic illness
  • Person groups:
    • Older adults

Keywords

  • aducanumab
  • aged
  • Alzheimer dementia
  • Alzheimer disease
  • amyloid
  • antibodies, monoclonal
  • ARIA
  • biological therapy
  • cerebral edema
  • cerebral hemorrhage
  • chronic disease
  • dementia
  • donanemab
  • drug approval
  • lecanemab
  • meta-analysis
  • risks and benefits
  • systematic review

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