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Review ArticleSystematic Review

Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis

Mark H. Ebell, Henry C. Barry, Kanishka Baduni and Gabrielle Grasso
The Annals of Family Medicine January 2024, 22 (1) 50-62; DOI: https://doi.org/10.1370/afm.3050
Mark H. Ebell
1Department of Epidemiology and Biostatistics, College of Public Health, the University of Georgia, Athens, Georgia
MD, MS
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  • For correspondence: ebell@uga.edu
Henry C. Barry
2Department of Family Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan
MD, MS
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Kanishka Baduni
3Department of Kinesiology, College of Education, the University of Georgia, Athens, Georgia
MPT
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Gabrielle Grasso
1Department of Epidemiology and Biostatistics, College of Public Health, the University of Georgia, Athens, Georgia
MPH
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The Annals of Family Medicine: 22 (1)
The Annals of Family Medicine: 22 (1)
Vol. 22, Issue 1
January/February 2024
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Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis
Mark H. Ebell, Henry C. Barry, Kanishka Baduni, Gabrielle Grasso
The Annals of Family Medicine Jan 2024, 22 (1) 50-62; DOI: 10.1370/afm.3050

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Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis
Mark H. Ebell, Henry C. Barry, Kanishka Baduni, Gabrielle Grasso
The Annals of Family Medicine Jan 2024, 22 (1) 50-62; DOI: 10.1370/afm.3050
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Subjects

  • Domains of illness & health:
    • Chronic illness
  • Person groups:
    • Older adults

Keywords

  • aducanumab
  • aged
  • Alzheimer dementia
  • Alzheimer disease
  • amyloid
  • antibodies, monoclonal
  • ARIA
  • biological therapy
  • cerebral edema
  • cerebral hemorrhage
  • chronic disease
  • dementia
  • donanemab
  • drug approval
  • lecanemab
  • meta-analysis
  • risks and benefits
  • systematic review

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