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Research ArticleOriginal Research

Major Depression Symptoms in Primary Care and Psychiatric Care Settings: A Cross-Sectional Analysis

Bradley N. Gaynes, A. John Rush, Madhukar H. Trivedi, Stephen R. Wisniewski, G. K. Balasubramani, Donald C. Spencer, Timothy Petersen, Michael Klinkman, Diane Warden, Linda Nicholas and Maurizio Fava
The Annals of Family Medicine March 2007, 5 (2) 126-134; DOI: https://doi.org/10.1370/afm.641
Bradley N. Gaynes
MD, MPH
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A. John Rush
MD
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Madhukar H. Trivedi
MD
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Stephen R. Wisniewski
PhD
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G. K. Balasubramani
PhD
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Donald C. Spencer
MD, MBA
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Timothy Petersen
PhD
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Michael Klinkman
MD
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Diane Warden
PhD
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Linda Nicholas
MD, MS
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Maurizio Fava
MD
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  • Figure 1.
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    Figure 1.

    Distribution of IDS-C30 by setting.
 IDS-C30 = 30-item Inventory of Depressive Symptomatology.

Tables

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    Table 1.

    Baseline Characteristics by Setting: Clinical Severity and Sociodemographic Features, by Recruitment Setting

    Primary CareSpecialty CareTotal
    Baseline Characteristicsn = 1,063 (41.8%)n = 1,478 (58.2%)N = 2,541
    Mean (SD)Mean (SD)Mean (SD)PValue
    HRSD17 = 17-item Hamilton Rating Scale for Depression; ROA = research outcome assessor; IDS-C30: 30-item Inventory of Depressive Symptomatology, Clinician Rating.
    * Public Insurance includes both Medicare and Medicaid.
    HRSD17 (ROA)19.6 (6.5)19.7 (6.4)19.6 (6.5).839
    IDS-C30 (ROA)35.2 (11.6)35.4 (11.3)35.3 (11.4).699
    Age, years43.7 (13.3)38.2 (13.0)40.5 (13.4)<.001
    Years of schooling12.8 (3.5)13.8 (2.9)13.4 (3.2)<.001
    Race, %.866
        White73.974.674.3
        Black or African American17.616.817.1
        Others8.58.68.6
    Ethnicity, Hispanic, %22.09.314.6<.001
    Sex, female, %68.059.062.8<.001
    Marital Status, %<.001
        Never married25.334.630.7
        Married42.939.440.8
        Divorced26.124.225.0
        Widowed5.71.83.5
    Employment status, %.029
        Unemployed38.038.338.2
        Employed55.157.256.3
        Retired6.94.45.5
    Insurance Status, %<.001
        Private insurance44.252.348.9
        Public insurance*22.18.415.5
        No insurance30.739.335.6
    Level of education, %<.001
        Less than completed college80.172.675.7
        Completed college or more19.927.424.3
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    Table 2.

    Current General Medical Conditions and Function/Quality of Life, by Recruitment Setting

    Primary CareSpecialty Care
    n = 1,063 (41.8%)n = 1,478 (58.2%)
    Baseline CharacteristicsMean (SD)Adjusted Mean (SE)Mean (SD)Adjusted Mean (SE)Total N = 2,541 Mean (SD)UnadjustedPValueAdjustedPValue*
    CIRS = Cumulative Illness Rating Scale; SF-12 = 12-Item Health Survey; WSAS = Work and Social Adjustment Scale; Q-LES-Q = Quality of Life Enjoyment and Satisfaction Questionnaire.
    * Adjusted for age, sex, education, marital status, employment status, ethnicity, length of current episode, and CIRS total score.
    CIRS, total score5.1 (4.1)–3.9 (3.7)–4.4 (3.9)<.001–
    SF-12
        Physical46.4 (12.3)47.6 (0.5)51.1 (11.6)49.5 (0.5)49.2 (12.1)<.001.004
        Mental28.9 (9.8)28.7 (0.4)25.5 (8.3)26.2 (0.4)26.9 (8.8)<.001<.001
    WSAS22.3 (9.8)21.8 (0.5)24.4 (8.9)24.2 (0.4)23.5 (9.3)<.001<.001
    Q-LES-Q42.7 (15.9)44.0 (0.7)41.0( 14.9)41.2 (0.7)41.7 (15.4)0.013<.001
    • View popup
    Table 3.

    Association of Primary/Specialty Setting With Psychiatric Comorbidities

    Primary CareSpecialty CareUnadjustedAdjusted*
    n = 1,063n = 1,478
    Type and No. of Psychiatric Comorbidity(41.8%) %(58.2%) %ORPValueORPValue
    Type of psychiatric comorbidity
    Anxiety disorders48.651.61.06.1431.23.019
        Social phobia25.332.11.39.0011.37.002
        Generalized anxiety disorder2.321.21.05.6041.26.037
        Posttraumatic stress disorder16.517.61.08.4941.26.054
        Obsessive compulsive disorder15.113.40.87.2280.96.755
        Panic14.511.10.74.0120.88.333
        Agoraphobia12.211.70.96.7291.33.046
    Nonanxiety disorders29.333.01.13.0511.21.043
        Alcohol abuse1.413.11.30.0441.21.411
        Drug abuse6.09.11.57.0051.22.245
        Somatoform3.01.80.59.050.98.947
        Hypochondriasis6.13.30.52.0010.79.285
        Bulimia1.813.41.27.0561.36.025
    Prevalence of any psychiatric comorbidity59.264.11.23.0141.31.003
    UnadjustedAdjusted*
    No.No.PValuePValue
    ns = not significant.
    * Adjusted for age, sex, education, employment status, marital status, ethnicity, length of current episode and CIRS (total score).
    No. of psychiatric comorbidities
    Mean1.41.5.041.002
    Median1.01.0nsns

Additional Files

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  • Supplemental Table

    Supplemental Table: Percentage of Patients With Specific Depressive Symptoms (IDS-C30 by ROA)

    Files in this Data Supplement:

    • Supplemental data: Table - PDF file, 1 page, 82 KB
  • The Article in Brief

    Major Depression Symptoms in Primary Care and Psychiatric Care Settings: A Cross-Sectional Analysis

    Bradley N. Gaynes, MD, MPH, and colleagues

    Background Depressed patients are more likely to see a primary care doctor than a mental health specialist for diagnosis and treatment of depression. This study compares characteristics and conditions of depressed patients in primary care and psychiatric specialty care settings.

    What This Study Found Patients with major depression in primary care and specialty care settings have similar symptoms and similar levels of depression. Risk factors for suicide are commonly seen in both settings, although they are more frequent in specialty care. In each setting, more than half of depressed patients had another psychiatric illness, in addition to depression.

    Implications

    • These findings challenge the suggestion that depressed patients in primary care settings are less depressed than those in specialty care settings.
    • Research results based on similar patient populations may be applicable to both primary care and specialty care practices.
    • The care of major depression increasingly falls on primary care doctors as better treatments become available and as community mental health clinics begin restricting treatment to patients with more
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The Annals of Family Medicine: 5 (2)
The Annals of Family Medicine: 5 (2)
Vol. 5, Issue 2
1 Mar 2007
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Major Depression Symptoms in Primary Care and Psychiatric Care Settings: A Cross-Sectional Analysis
Bradley N. Gaynes, A. John Rush, Madhukar H. Trivedi, Stephen R. Wisniewski, G. K. Balasubramani, Donald C. Spencer, Timothy Petersen, Michael Klinkman, Diane Warden, Linda Nicholas, Maurizio Fava
The Annals of Family Medicine Mar 2007, 5 (2) 126-134; DOI: 10.1370/afm.641

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Major Depression Symptoms in Primary Care and Psychiatric Care Settings: A Cross-Sectional Analysis
Bradley N. Gaynes, A. John Rush, Madhukar H. Trivedi, Stephen R. Wisniewski, G. K. Balasubramani, Donald C. Spencer, Timothy Petersen, Michael Klinkman, Diane Warden, Linda Nicholas, Maurizio Fava
The Annals of Family Medicine Mar 2007, 5 (2) 126-134; DOI: 10.1370/afm.641
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