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Research ArticleOriginal Research

Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties

Peter Hanlon, Terence J. Quinn, Katie I. Gallacher, Phyo K. Myint, Bhautesh Dinesh Jani, Barbara I. Nicholl, Richard Lowrie, Roy L. Soiza, Samuel R. Neal, Duncan Lee and Frances S. Mair
The Annals of Family Medicine March 2020, 18 (2) 148-155; DOI: https://doi.org/10.1370/afm.2501
Peter Hanlon
1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
MSc
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Terence J. Quinn
2Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
MD
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Katie I. Gallacher
1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
PhD
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Phyo K. Myint
3Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom
4Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, Scotland, United Kingdom
MD
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Bhautesh Dinesh Jani
1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
PhD
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Barbara I. Nicholl
1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
PhD
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Richard Lowrie
5Pharmacy and Prescribing Support Unit, NHS Greater Glasgow and Clyde, West Glasgow Ambulatory Care Unit, Glasgow, Scotland, United Kingdom
PhD
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Roy L. Soiza
3Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom
4Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, Scotland, United Kingdom
MRCP
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Samuel R. Neal
3Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom
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Duncan Lee
6School of Mathematics and Statistics, University of Glasgow, University Place, Glasgow, Scotland, United Kingdom
PhD
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Frances S. Mair
1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
MD
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  • For correspondence: frances.mair@glasgow.ac.uk
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Article Information

vol. 18 no. 2 148-155
DOI 
https://doi.org/10.1370/afm.2501
PubMed 
32152019

Published By 
The Annals of Family Medicine
Print ISSN 
1544-1709
Online ISSN 
1544-1717
History 
  • Received for publication April 18, 2019
  • Revision received July 24, 2019
  • Accepted for publication August 16, 2019
  • Published online March 9, 2020.

Copyright & Usage 
© 2020 Annals of Family Medicine, Inc.

Author Information

  1. Peter Hanlon, MSc1,
  2. Terence J. Quinn, MD2,
  3. Katie I. Gallacher, PhD1,
  4. Phyo K. Myint, MD3,4,
  5. Bhautesh Dinesh Jani, PhD1,
  6. Barbara I. Nicholl, PhD1,
  7. Richard Lowrie, PhD5,
  8. Roy L. Soiza, MRCP3,4,
  9. Samuel R. Neal3,
  10. Duncan Lee, PhD6 and
  11. Frances S. Mair, MD1⇑
  1. 1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
  2. 2Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
  3. 3Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom
  4. 4Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, Scotland, United Kingdom
  5. 5Pharmacy and Prescribing Support Unit, NHS Greater Glasgow and Clyde, West Glasgow Ambulatory Care Unit, Glasgow, Scotland, United Kingdom
  6. 6School of Mathematics and Statistics, University of Glasgow, University Place, Glasgow, Scotland, United Kingdom
  1. CORRESPONDING AUTHOR: Frances S. Mair, MD, General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, 1 Horelethill Road, Glasgow, G12 9LX, Scotland, United Kingdom, frances.mair{at}glasgow.ac.uk

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The Annals of Family Medicine: 18 (2)
The Annals of Family Medicine: 18 (2)
Vol. 18, Issue 2
March/April 2020
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Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties
Peter Hanlon, Terence J. Quinn, Katie I. Gallacher, Phyo K. Myint, Bhautesh Dinesh Jani, Barbara I. Nicholl, Richard Lowrie, Roy L. Soiza, Samuel R. Neal, Duncan Lee, Frances S. Mair
The Annals of Family Medicine Mar 2020, 18 (2) 148-155; DOI: 10.1370/afm.2501

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Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties
Peter Hanlon, Terence J. Quinn, Katie I. Gallacher, Phyo K. Myint, Bhautesh Dinesh Jani, Barbara I. Nicholl, Richard Lowrie, Roy L. Soiza, Samuel R. Neal, Duncan Lee, Frances S. Mair
The Annals of Family Medicine Mar 2020, 18 (2) 148-155; DOI: 10.1370/afm.2501
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  • Anticholinergic burden in middle and older age is associated with lower cognitive function, but not with brain atrophy
  • Association between anticholinergic burden and dementia in UK Biobank
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Subjects

  • Person groups:
    • Older adults
    • Community / population health
  • Methods:
    • Qualitative methods
  • Core values of primary care:
    • Comprehensiveness
  • Other topics:
    • Multimorbidity

Keywords

  • anticholinergic burden
  • polypharmacy
  • multimorbidity
  • mortality
  • cardiovascular events

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