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Research ArticleOriginal Research

Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties

Peter Hanlon, Terence J. Quinn, Katie I. Gallacher, Phyo K. Myint, Bhautesh Dinesh Jani, Barbara I. Nicholl, Richard Lowrie, Roy L. Soiza, Samuel R. Neal, Duncan Lee and Frances S. Mair
The Annals of Family Medicine March 2020, 18 (2) 148-155; DOI: https://doi.org/10.1370/afm.2501
Peter Hanlon
1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
MSc
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Terence J. Quinn
2Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
MD
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Katie I. Gallacher
1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
PhD
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Phyo K. Myint
3Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom
4Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, Scotland, United Kingdom
MD
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Bhautesh Dinesh Jani
1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
PhD
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Barbara I. Nicholl
1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
PhD
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Richard Lowrie
5Pharmacy and Prescribing Support Unit, NHS Greater Glasgow and Clyde, West Glasgow Ambulatory Care Unit, Glasgow, Scotland, United Kingdom
PhD
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Roy L. Soiza
3Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom
4Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, Scotland, United Kingdom
MRCP
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Samuel R. Neal
3Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom
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Duncan Lee
6School of Mathematics and Statistics, University of Glasgow, University Place, Glasgow, Scotland, United Kingdom
PhD
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Frances S. Mair
1General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, United Kingdom
MD
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  • For correspondence: frances.mair@glasgow.ac.uk
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The Annals of Family Medicine: 18 (2)
The Annals of Family Medicine: 18 (2)
Vol. 18, Issue 2
March/April 2020
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Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties
Peter Hanlon, Terence J. Quinn, Katie I. Gallacher, Phyo K. Myint, Bhautesh Dinesh Jani, Barbara I. Nicholl, Richard Lowrie, Roy L. Soiza, Samuel R. Neal, Duncan Lee, Frances S. Mair
The Annals of Family Medicine Mar 2020, 18 (2) 148-155; DOI: 10.1370/afm.2501

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Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties
Peter Hanlon, Terence J. Quinn, Katie I. Gallacher, Phyo K. Myint, Bhautesh Dinesh Jani, Barbara I. Nicholl, Richard Lowrie, Roy L. Soiza, Samuel R. Neal, Duncan Lee, Frances S. Mair
The Annals of Family Medicine Mar 2020, 18 (2) 148-155; DOI: 10.1370/afm.2501
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  • Managing drugs with anticholinergic activity
  • Anticholinergic burden in middle and older age is associated with lower cognitive function, but not with brain atrophy
  • Association between anticholinergic burden and dementia in UK Biobank
  • Increase in anticholinergic burden in the UK from 1990 to 2015: a UK Biobank study
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Subjects

  • Person groups:
    • Older adults
    • Community / population health
  • Methods:
    • Qualitative methods
  • Core values of primary care:
    • Comprehensiveness
  • Other topics:
    • Multimorbidity

Keywords

  • anticholinergic burden
  • polypharmacy
  • multimorbidity
  • mortality
  • cardiovascular events

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