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Research ArticleOriginal Research

Health Care of Young Adult Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study

Kevin C. Oeffinger, Ann C. Mertens, Melissa M. Hudson, James G. Gurney, Jacqueline Casillas, Hegang Chen, John Whitton, Mark Yeazel, Yutaka Yasui and Leslie L. Robison
The Annals of Family Medicine January 2004, 2 (1) 61-70; DOI: https://doi.org/10.1370/afm.26
Kevin C. Oeffinger
MD
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Ann C. Mertens
PhD
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Melissa M. Hudson
MD
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James G. Gurney
PhD
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Jacqueline Casillas
MD
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Hegang Chen
PhD
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John Whitton
MS
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Mark Yeazel
MD, MPH
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Yutaka Yasui
PhD
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Leslie L. Robison
PhD
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  • Figure 1.
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    Figure 1.

    Percentage of adult survivors of childhood cancer with medical visits in a 2-year period by interval from cancer diagnosis to baseline questionnaire.

    * Trend significant with P <.001 for general physical education, cancer-related medical visit, and cancer center medical visit by Cochran-Armitage trend test.

  • Figure 2.
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    Figure 2.

    Percentage of adult survivors of 4 higher risk cancer groups with a cancer-related medical visit in a 2-year period by interval from cancer diagnosis to baseline questionnaire.

    Note: Trend significant with P <.001 for bone tumor, central nervous system (CNS) tumor, Hodgkin’s disease, and leukemia survivors by Cochran-Armitage trend test.

Tables

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    Table 1.

    Percentage of Adult Survivors of Childhood Cancer Who Reported the Following Types of Outpatient Medical Care in a 2-Year Period: Sociodemographic Factors

    FactorNumberGeneral Medical Contact (%)General Physical Examination (%)Cancer- Related Medical Visit (%)Cancer Center Medical Visit (%)
    <HS graduate = some high school, did not graduate; HS/some college = high school graduate or high school graduate with some college courses.
    Note: Percentages are based upon the total with available data for each variable.
    Age at interview
    18–19 y1,12688.482.748.631.0
    20–24 y2,75287.773.145.124.2
    25–29 y2,52885.867.638.721.5
    30–34 y1,84986.865.039.917.5
    35–48 y1,17986.867.037.816.6
    Sex
    Male5,02082.065.339.622.3
    Female4,41493.675.844.521.9
    Race/ethnicity
    White, non-Hispanic7,88687.770.241.821.5
    Black, non-Hispanic39279.172.934.820.0
    Hispanic43483.271.247.332.2
    Others27382.669.045.124.7
    Education
    <HS graduate95982.868.144.426.2
    HS/some college5,23985.669.240.221.3
    College graduate2,72390.572.243.722.7
    Health insurance
    Yes7,83588.773.043.522.4
    No1,43978.155.232.819.7
    Household income
    <$20,0001,87083.764.941.520.0
    ≥$20,0006,40388.572.341.922.3
    • View popup
    Table 2.

    Percentage of Adult Survivors of Childhood Cancer Who Reported the Following Types of Outpatient Medical Care in a 2-Year Period: Cancer-Related Factors

    FactorNumberGeneral Medical Contact %General Physical Examination %Cancer-Related Medical Visit %Cancer Center Medical Visit %
    Note: Percentages are based upon the total with available data for each variable.
    Age at diagnosis
    0–4 y2,42686.072.436.418.2
    5–9 y2,33686.271.641.123.3
    10–14 y2,54087.268.443.523.6
    15–21 y2,13288.669.046.923.2
    Interval from cancer diagnosis
    5–9 y29393.876.664.439.6
    10–14 y2,47288.574.053.531.2
    15–19 y3,45687.372.840.521.4
    20–24 y2,60285.565.233.414.2
    25–29 y61182.260.628.011.5
    Cancer diagnosis
    Leukemia2,84685.072.436.322.4
    Central nervous system tumor1,16688.666.352.914.8
    Hodgkin’s disease1,63190.676.052.629.9
    Non-Hodgkin’s lymphoma86584.268.336.921.6
    Wilms’ tumor63088.268.833.718.0
    Neuroblastoma39986.468.928.013.8
    Sarcoma89475.067.839.919.6
    Bone1,00388.465.443.824.9
    Subjective health status
    Excellent1,95482.372.734.822.0
    Very good3,55387.972.840.122.0
    Good2,83488.668.745.122.4
    Fair84487.963.751.821.6
    Poor14689.751.162.124.4
    Future health concerns
    Very concerned2,78788.973.548.023.9
    Somewhat concerned1,90189.571.744.524.8
    Concerned2,29887.170.040.421.7
    Not very concerned1,41385.667.335.519.5
    Not concerned at all81078.362.131.015.1
    Cancer pain
    None7,09286.371.338.821.0
    Small97690.069.949.925.0
    Medium60889.467.354.226.6
    A lot23288.767.359.327.9
    Very bad7786.852.163.430.3
    Cancer anxiety
    None5,23083.869.535.919.8
    Small2,51391.872.747.323.6
    Medium80891.771.755.527.2
    A lot30090.973.159.330.4
    Very many7390.461.448.531.8
    • View popup
    Table 3.

    Multivariate Risk Factors for Absence of the Following Types of Outpatient Medical Care in a 2-Year Period in Adult Survivors of Childhood Cancer

    Absence of
    General Medical ContactGeneral Physical ExaminationCancer-Related Medical VisitCancer Center Medical Visit
    VariableOR95% CIOR95% CIOR95% CIOR95% CI
    OR = odds ratio; CI = confidence interval; <HS graduate = some high school, did not graduate; HS/some college = high school graduate or high school graduate with some college courses.
    * High-risk treatment = treatment with any of the following: chest or mantle radiation, anthracycline ≥300 mg/m2, bleomycin, etoposide, or ifosfamide.
    Age at interview
    18–19 y1.00Referent1.00Referent1.00Referent1.00Referent
    20–24 y1.180.90–1.562.061.62–2.611.110.92–1.331.311.07–1.61
    25–29 y1.471.11–1.953.122.45–3.971.671.38–2.021.881.51–2.34
    30–34 y1.591.18–2.153.752.91–4.821.741.42–2.142.792.19–3.56
    ≥35 y1.711.23–2.373.642.78–4.762.291.83–2.873.432.61–4.51
    Sex
    Female1.00Referent1.00Referent1.00Referent1.00Referent
    Male2.542.15–2.991.531.36–1.711.181.06–1.301.151.01–1.30
    Ethnicity
    White, non-Hispanic1.00Referent1.00Referent1.00Referent1.00Referent
    Minority1.531.21–1.930.810.66–0.990.970.81–1.160.790.64–0.96
    Education
    College graduate1.00Referent1.00Referent1.00Referent1.00Referent
    HS/some college1.481.22–1.791.211.06–1.381.161.03–1.311.251.08–1.44
    <HS graduate1.881.41–2.521.341.06–1.701.140.92–1.411.070.84–1.37
    Health insurance
    Yes1.00Referent1.00Referent1.00Referent1.00Referent
    No2.141.78–2.572.191.87–2.561.641.40–1.921.411.16–1.70
    Health status
    Good1.00Referent1.00Referent1.00Referent1.00Referent
    Fair/poor0.940.72–1.221.421.18–1.710.620.52–0.741.010.82–1.24
    Concern for future health
    Concerned1.00Referent1.00Referent1.00Referent1.00Referent
    Not concerned1.441.21–1.711.381.21–1.581.511.33–1.711.531.31–1.79
    High-risk treatment*
    No1.00Referent1.00Referent1.00Referent1.00Referent
    Yes0.730.62–0.860.720.64–0.810.590.52–0.650.450.39–0.51
    • View popup
    Table 4.

    Percentage of Adult Survivors of Childhood Cancer Treated With Therapies Associated With Increased Risk for Late Effects Reporting an Absence of the Following Types of Outpatient Medical Care in a 2-Year Period, Compared With All Survivors

    Absence of
    General Medical ContactGeneral Physical ExaminationCancer-Related Medical VisitCancer Center Medical Visit
    VariableTotal No.%OR(95% CI)%OR(95% CI)%OR(95% CI)%OR(95% CI)
    Note: results adjusted for age, sex, and race; percentages are based upon the total with available data for each variable.
    OR = odds ratio; CI = confidence intervals; RT = radiation therapy.
    * High-risk therapy: treatment with any of the following: chest-mantle radiation, anthracycline >300 mg/m2, bleomycin, etoposide, or ifosfamide.
    Chest-mantle RT
    No6,01312.51.00Referent30.61.00Referent59.41.00Referent79.71.00Referent
    Yes1,8028.20.680.57–0.8324.60.640.56–0.7347.90.600.53–0.6770.30.500.43–0.57
    Anthracycline
    <300 mg/m26,45911.11.00Referent29.41.00Referent53.61.00Referent72.61.00Referent
    ≥300 mg/m21,50810.70.880.73–1.06z27.40.960.84–1.1151.70.770.68–0.8869.80.650.56–0.75
    Bleomycin
    No7,64212.21.00Referent29.41.00Referent58.41.00Referent81.51.00Referent
    Yes5817.80.580.42–0.8125.70.800.65–0.9940.80.480.40–0.5867.00.470.38–0.57
    High-risk therapy*
    No4,30413.21.00Referent31.31.00Referent61.91.00Referent83.11.00Referent
    Yes3,44910.00.700.60–0.8226.40.740.66–0.8350.70.580.53–0.6571.10.450.39–0.50
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The Annals of Family Medicine: 2 (1)
The Annals of Family Medicine: 2 (1)
Vol. 2, Issue 1
1 Jan 2004
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Health Care of Young Adult Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study
Kevin C. Oeffinger, Ann C. Mertens, Melissa M. Hudson, James G. Gurney, Jacqueline Casillas, Hegang Chen, John Whitton, Mark Yeazel, Yutaka Yasui, Leslie L. Robison
The Annals of Family Medicine Jan 2004, 2 (1) 61-70; DOI: 10.1370/afm.26

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Health Care of Young Adult Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study
Kevin C. Oeffinger, Ann C. Mertens, Melissa M. Hudson, James G. Gurney, Jacqueline Casillas, Hegang Chen, John Whitton, Mark Yeazel, Yutaka Yasui, Leslie L. Robison
The Annals of Family Medicine Jan 2004, 2 (1) 61-70; DOI: 10.1370/afm.26
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