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Research ArticleORIGINAL RESEARCH

Reducing Readmission of Hospitalized Patients With Depressive Symptoms: A Randomized Trial

Suzanne E. Mitchell, Matthew Reichert, Jessica Martin Howard, Katherine Krizman, Alexa Bragg, Molly Huffaker, Kimberly Parker, Mary Cawley, Hannah Webb Roberts, Yena Sung, Jennifer Brown, Larry Culpepper, Howard J. Cabral and Brian W. Jack
The Annals of Family Medicine May 2022, 20 (3) 246-254; DOI: https://doi.org/10.1370/afm.2801
Suzanne E. Mitchell
1Department of Family Medicine, Boston University School of Medicine, Boston, Massachusetts
2Department of Family Medicine, Boston Medical Center, Boston, Massachusetts
3Department of Family Medicine, University of Massachusetts Medical School, Worcester, Massachusetts
MD, MSc
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  • For correspondence: Suzanne.Mitchell@bmc.org
Matthew Reichert
2Department of Family Medicine, Boston Medical Center, Boston, Massachusetts
4Department of Government, Harvard University, Cambridge, Massachusetts
MA
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Jessica Martin Howard
1Department of Family Medicine, Boston University School of Medicine, Boston, Massachusetts
MA, MPH
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Katherine Krizman
1Department of Family Medicine, Boston University School of Medicine, Boston, Massachusetts
LMHC, LPCC
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Alexa Bragg
1Department of Family Medicine, Boston University School of Medicine, Boston, Massachusetts
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Molly Huffaker
2Department of Family Medicine, Boston Medical Center, Boston, Massachusetts
JD
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Kimberly Parker
1Department of Family Medicine, Boston University School of Medicine, Boston, Massachusetts
MS, PMP
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Mary Cawley
1Department of Family Medicine, Boston University School of Medicine, Boston, Massachusetts
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Hannah Webb Roberts
2Department of Family Medicine, Boston Medical Center, Boston, Massachusetts
MPH, MSN
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Yena Sung
2Department of Family Medicine, Boston Medical Center, Boston, Massachusetts
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Jennifer Brown
5Department of Psychiatry, Mount Auburn Hospital, Cambridge, Massachusetts
MD
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Larry Culpepper
1Department of Family Medicine, Boston University School of Medicine, Boston, Massachusetts
MD, MPH
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Howard J. Cabral
6Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts
PhD
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Brian W. Jack
1Department of Family Medicine, Boston University School of Medicine, Boston, Massachusetts
2Department of Family Medicine, Boston Medical Center, Boston, Massachusetts
MD
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  • Figure 1.
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    Figure 1.

    Study flowchart.

    CAGE = 4-item screening for alcohol use: cutting down, annoyance by criticism, guilty feeling, and eye-openers; DAST = 10-item drug abuse screening test; PHQ-9 = patient health questionnaire-9; PHQ-2 = patient health questionnaire-2; RED = re-engineered discharge; RED-D = re-engineered discharge for depression.

    a Medical exclusion occurred in phases. Patients admitted for altered mental status, end-of-life care, sickle cell crisis, or substance use were excluded from the pool immediately. Then, potentially eligible patients were excluded if they were going to be discharged to another inpatient facility, pregnant, under suicide precautions, undergoing cancer treatment; admitted to a surgical trauma unit.

    b Other reasons for exclusion included: incarceration; no access to telephone; no primary care clinician; not staying in the area during the study; aged <18 years; enrolled in another discharge planning program.

    c Medical exclusions after consent were for having a serious mental illness diagnosis, self-reported suicidal ideation, and self-reported alcohol or drug abuse (CAGE score >2, DAST score >5).

  • Figure 2.
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    Figure 2.

    Readmission and reutilization rates for intervention patients by the number of counselling sessions completed at 90 days.

    IRR = incidence rate ratio.

    Note: Labeled points indicate predicted values from Poisson regression of 90-day readmission and reutilization rates on cumulative dosage of the intervention. Each value represents the readmission or reutilization rate we would expect at that associated dosage, based on regression models.

  • Figure 3.
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    Figure 3.

    Predicted readmission rate at 90 days by type of post-discharge support for intervention participants receiving 6 or more sessions.

    Note: Predicted values were generated using Poisson regression.

    a Self-management was counselling focused on chronic disease self-management, including diet/nutrition, exercise, managing medications, talking to your doctor, and coping with exacerbations.

    b Patient navigation includes guidance in navigating difficult aspects of the health care system, such as overcoming financial barriers, scheduling appointments, and coordinating transportation services, as well as adherence to the discharge plan and follow-up care.

    c Brief cognitive behavior therapy includes orientation to the thought-feeling connection, transforming negative thoughts, behavior activation, physical symptoms, and stress management and navigating relationships, and homework.25

Tables

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    Table 1.

    Demographic and Clinical Characteristics at Enrollmenta

    CharacteristicControl
    (n = 356)
    Intervention
    (n = 353)
    Women, No. (%)221 (62.1)210 (59.5)
    Age, mean (SD)51 (13.7)50 (13.4)
    Race, No. (%)
        White non-Hispanic129 (36.2)112 (31.7)
        Black non-Hispanic147 (41.3)160 (45.3)
        Hispanic59 (16.6)67 (19.0)
        Other race52 (14.6)42 (11.9)
    Annual personal income, $, No. (%)
        <10,00048 (13.5)40 (11.3)
        10,000-19,99965 (18.3)66 (18.7)
        20,000-49,99949 (13.8)58 (16.4)
        ≥50,00043 (12.1)34 (9.6)
        No personal income25 (7.0)24 (6.8)
        Refused51 (14.3)53 (15.0)
        Did not know74 (20.8)77 (21.8)
    Education level, No. (%)
        Less than high school14 (3.9)16 (4.5)
        Some high school47 (13.2)40 (11.3)
        High school graduate or GED134 (37.6)124 (35.1)
        Some college104 (29.2)111 (31.4)
        4-year college graduate or higher57 (16.0)61 (17.3)
    Health literacy level, grade level, No. (%)b
        ≤30 (0.0)3 (0.8)
        4-69 (2.5)11 (3.1)
        7-849 (13.8)53 (15.0)
        ≥9232 (65.2)196 (55.5)
        Did not report66 (18.5)90 (25.6)
    Current employment status, No. (%)
        Full-time60 (16.9)76 (21.5)
        Part-time36 (10.1)29 (8.2)
        Homemaker3 (0.8)7 (2.0)
        Student4 (1.1)3 (0.8)
        Retired63 (17.7)51 (14.4)
        Disabled120 (33.7)119 (33.7)
        Unemployed56 (15.7)62 (17.6)
        Otherc14 (3.9)5 (1.4)
    Recruitment site, No. (%)
        Boston Medical Center328 (92.1)325 (92.1)
        Mt Auburn Hospital28 (7.9)28 (7.9)
        Homeless in past 6 months, No. (%)28 (7.9)24 (6.8)
    Major depressive disorder, No. (%)c110 (30.9)96 (27.2)
    Mean PHQ-9, (SD)d15 (4.2)15 (4.2)
    Q-LES-Q-SF, mean (SD)e45 (15.9)45 (16.0)
    GAD-7, mean (SD)f11 (5.5)10 (5.8)
    PAM-13, mean (SD)g42 (5.6)42 (5.5)
    Medication for depression, No. (%)h140 (39.3)123 (34.8)
    • GAD = generalized anxiety disorder; GED = general equivalency diploma; PAM = patient activation measure; PHQ-9 = patient health questionnaire-9; Q-LES-Q-SF = quality of life enjoyment and satisfaction questionnaire – short form.

    • ↵a Not all column percentages sum to 100% due to missing values.

    • ↵b REALM (Rapid Estimate of Adult Literacy in Medicine). Health literacy categories correspond to scores of grade 3 or below (REALM score, 0-18), grade 4 to 6 (REALM score, 19-44), grade 7 to 8 (REALM score, 45-60), and grade 9 or above (REALM score, 61-66).20

    • ↵c Determined by clinical interview by licensed mental health counselor after enrollment.

    • ↵d Patient Health Questionnaire-9 is a 9-item scale. A score of ≥10 indicates moderate depressive symptoms.16

    • ↵e Quality of Life Enjoyment and Satisfaction Questionnaire Short Form is a 16-item scale indicating the degree of enjoyment and satisfaction experienced by participants in various areas of daily functioning. The reported score is the sum of the question responses rescaled to 100. Higher scores indicate higher enjoyment and satisfaction.21

    • ↵f Generalized Anxiety Disorder 7 is a 7-item scale. A score of 10-14 indicates possible clinically significant generalized anxiety and ≥15 indicates that treatment is probably warranted.23

    • ↵g Patient Activation Measure 13 is a 13-item scale indicating the degree of patients’ willingness and ability to take independent actions to manage their health and care. Raw scores converted to range from 0-100 with ≤47.0 not believing activation important; 47.1-55.1 indicating a lack of knowledge and confidence to take action; 55.2-67.0 beginning to take action; and ≥67.1 taking action.22

    • ↵h Self-reported answer to the question “Are you currently taking medication for depression?”

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    Table 2.

    Primary Outcomes: Intention-to-Treat and As-Treated Analysis at 30 and 90 Days

    Intention-to-Treat Analysis
    As-Treated Analysis
    As-Treated Analysis
    30-Day Outcomes
    Type of Primary OutcomeControla
    (n = 356), No. (%)
    Interventionb
    (n = 353), No. (%)
    P Value, IRR (95% CI)≥3 Sessionsc
    (n = 104), No. (%)
    P Value, IRR (95% CI)
    Hospital utilizationsd82 (0.24)89 (0.27).386, 1.14 (0.85-1.54)20 (0.17).377, 0.80 (0.48-1.28)
    ED visits32 (0.09)32 (0.10).839, 1.05 (0.64-1.72)9 (0.09).653, 0.93 (0.42-1.86)
    Readmissionse33 (0.10)29 (0.09).758, 0.92 (0.56-1.52)3 (0.03).012, 0.30 (0.07-0.84)f
    Observations17 (0.05)28 (0.09).215, 1.73 (0.96-3.23)8 (0.08)0.343, 1.55 (0.63-3.49)
    90-Day Outcomes
    Controla (n = 356), No. (%)Interventionb
    (n = 353), No. (%)
    P Value, IRR (95% CI)≥6 Sessionsg
    (n = 109), No. (%)
    P Value, IRR (95% CI)
    Hospital utilizationsd189 (0.57)219 (0.70).041, 1.22 (1.01-1.49)48 (0.44).162, 0.78 (0.56-1.06)
    ED visits82 (0.25)86 (0.27)0.504, 1.11 (0.82-1.50)23 (0.21).544, 0.86 (0.53-1.34)
    Readmissionse71 (0.21)87 (0.28).106, 1.30 (0.95-1.78)12 (0.11).030, 0.52 (0.27-0.92)f
    Observations36 (0.11)46 (0.15).177, 1.35 (0.88-2.10)13 (0.12).797, 1.1 (0.56-2.03)
    • ED = emergency department; IRR = incidence rate ratios; RED = re-engineered discharge; RED-D = re-engineered discharge for depression.

    • ↵a Control group received the components of the re-engineered discharge (RED).10

    • ↵b Intervention group received the components of the re-engineered discharge, and were offered up to 12 weekly counselling sessions that included brief cognitive behavioral therapy, patient navigation, and self-management (RED-D).

    • ↵c ≥3 sessions includes those patients in the intervention group receiving 3 sessions of the intervention by 30 days.

    • ↵d Hospital reutilizations are defined as the sum of hospital readmission plus emergency department visits and observations after index discharge.

    • ↵e Readmissions are defined as 30 and 90 day all cause hospital readmissions after index discharge.

    • ↵f Results are statistically significant.

    • ↵g ≥6 sessions includes those patients in the intervention group receiving 6 sessions of the intervention by 90 days.

Additional Files

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Reducing Readmission of Hospitalized Patients With Depressive Symptoms: A Randomized Trial
Suzanne E. Mitchell, Matthew Reichert, Jessica Martin Howard, Katherine Krizman, Alexa Bragg, Molly Huffaker, Kimberly Parker, Mary Cawley, Hannah Webb Roberts, Yena Sung, Jennifer Brown, Larry Culpepper, Howard J. Cabral, Brian W. Jack
The Annals of Family Medicine May 2022, 20 (3) 246-254; DOI: 10.1370/afm.2801

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Reducing Readmission of Hospitalized Patients With Depressive Symptoms: A Randomized Trial
Suzanne E. Mitchell, Matthew Reichert, Jessica Martin Howard, Katherine Krizman, Alexa Bragg, Molly Huffaker, Kimberly Parker, Mary Cawley, Hannah Webb Roberts, Yena Sung, Jennifer Brown, Larry Culpepper, Howard J. Cabral, Brian W. Jack
The Annals of Family Medicine May 2022, 20 (3) 246-254; DOI: 10.1370/afm.2801
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