Skip to main content

Main menu

  • Home
  • Current Issue
  • Content
    • Current Issue
    • Early Access
    • Multimedia
    • Podcast
    • Collections
    • Past Issues
    • Articles by Subject
    • Articles by Type
    • Supplements
    • Plain Language Summaries
    • Calls for Papers
  • Info for
    • Authors
    • Reviewers
    • Job Seekers
    • Media
  • About
    • Annals of Family Medicine
    • Editorial Staff & Boards
    • Sponsoring Organizations
    • Copyrights & Permissions
    • Announcements
  • Engage
    • Engage
    • e-Letters (Comments)
    • Subscribe
    • Podcast
    • E-mail Alerts
    • Journal Club
    • RSS
    • Annals Forum (Archive)
  • Contact
    • Contact Us
  • Careers

User menu

  • My alerts

Search

  • Advanced search
Annals of Family Medicine
  • My alerts
Annals of Family Medicine

Advanced Search

  • Home
  • Current Issue
  • Content
    • Current Issue
    • Early Access
    • Multimedia
    • Podcast
    • Collections
    • Past Issues
    • Articles by Subject
    • Articles by Type
    • Supplements
    • Plain Language Summaries
    • Calls for Papers
  • Info for
    • Authors
    • Reviewers
    • Job Seekers
    • Media
  • About
    • Annals of Family Medicine
    • Editorial Staff & Boards
    • Sponsoring Organizations
    • Copyrights & Permissions
    • Announcements
  • Engage
    • Engage
    • e-Letters (Comments)
    • Subscribe
    • Podcast
    • E-mail Alerts
    • Journal Club
    • RSS
    • Annals Forum (Archive)
  • Contact
    • Contact Us
  • Careers
  • Follow annalsfm on Twitter
  • Visit annalsfm on Facebook
Research ArticleOriginal Research

Comparing the Diagnostic Performance of 2 Clinical Decision Rules to Rule Out Deep Vein Thrombosis in Primary Care Patients

Eit Frits van der Velde, Diane B. Toll, Arina J. ten Cate-Hoek, Ruud Oudega, Henri E. J. H. Stoffers, Patrick M. Bossuyt, Harry R. Büller, Martin H. Prins, Arno W. Hoes, Karel G. M. Moons and Henk C. P. M. van Weert
The Annals of Family Medicine January 2011, 9 (1) 31-36; DOI: https://doi.org/10.1370/afm.1198
Eit Frits van der Velde
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Diane B. Toll
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arina J. ten Cate-Hoek
MD, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ruud Oudega
MD, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Henri E. J. H. Stoffers
MD, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patrick M. Bossuyt
MD, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harry R. Büller
MD, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin H. Prins
MD, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arno W. Hoes
MD, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karel G. M. Moons
MD, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Henk C. P. M. van Weert
MD, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • PDF
Loading

Abstract

PURPOSE The Wells rule is widely used for clinical assessment of patients with suspected deep vein thrombosis (DVT), especially in the secondary care setting. Recently a new clinical decision rule for primary care patients (the primary care rule) has been proposed, because the Wells rule is not sufficient to rule out DVT in this setting. The objective was to compare the ability of both rules to safely rule out DVT and to efficiently reduce the number of referrals for leg ultrasound investigation that would result in a negative finding.

METHODS Family physicians collected data on 1,086 patients to calculate the scores for both decision rules before leg ultrasonography was performed. In all patients D-dimer (dimerized plasmin fragment D) testing was performed using a rapid point-of-care assay. Patients were stratified into risk categories defined by each rule and the D-dimer result. Outcomes were DVT (diagnosed by ultrasonography) and venous thromboembolic complications or death caused by a possible thromboembolic event during a 90-day follow-up period. We calculated the differences between the 2 rules in the number of missed diagnoses and the proportions of patients that needed ultrasound testing.

RESULTS Data from 1,002 eligible patients were used for this analysis. A venous thromboembolic event occurred during follow-up in 7 patients with a low score and negative D-dimer finding, both with the Wells rule (7 of 447; 1.6%; 95% confidence interval [CI], 0.7%–3.3% ) and the primary care rule (7 of 495; 1.4%; 95% CI, 0.6%–3.0%). Using the Wells rule, 447 patients (45%) would not need referral for further testing compared with 495 patients (49%) when using the primary care rule (McNemar P <.001).

CONCLUSIONS In primary care, suspected DVT can safely be ruled out using either of the 2 rules in combination with a point-of-care D-dimer test. Both rules can reduce unnecessary referrals for compression ultrasonography by about 50%, though the primary care rule reduces it slightly more.

  • Venous thrombosis
  • venous thromboembolism
  • D-dimer
  • clinical decision support systems
  • primary health care

INTRODUCTION

With an annual incidence of 1 to 2 per 1,000 inhabitants, deep vein thrombosis (DVT) is relatively rare in primary care, but it is feared for its associated morbidity and mortality if left untreated.1–4 When a family physician suspects DVT, most patients will be referred for additional testing. After the introduction of compression ultrasonography, the number of primary care patients referred for this noninvasive technique, which is highly accurate, increased progressively, partially because of improved accessibility and greater awareness for possible DVT. The result has been an increased number of diagnosed DVTs but at less-efficient use of resources and increased costs.5

Despite its widespread accessibility, ultrasonography may not be needed in all patients suspected of DVT. The availability of D-dimer (dimerized plasmin fragment D) testing made it possible to combine clinical assessment with this laboratory test to rule out DVT without the need for imaging tests.6 A diagnostic algorithm, based on a decision rule developed by Wells and colleagues that included information from a patient’s medical history and physical examination, followed by D-dimer testing, is now used to guide management in many hospitals worldwide (Table 1⇓).7 In the hospital setting the combination of a low clinical probability based on this decision rule and a negative D-dimer test result safely rules out DVT without the need for additional investigations.7,8 In all other cases, (serial) compression ultrasonography is indicated.

View this table:
  • View inline
  • View popup
Table 1.

Wells Rule and the Primary Care Rule Scoring to Rule Out Deep Vein Thrombosis (DVT)

Concerns have been raised that this strategy may not be as safe in primary care. A validation study showed that the Wells rule did not adequately rule out DVT in primary care patients, as 2.9% (95% confidence interval [CI] 2.5%–3.3%) of patients with DVT were missed, even after applying a qualitative, highly sensitive D-dimer test.9 This outcome was most likely because patient characteristics differed between primary and secondary care populations. One element in the Wells rule is an estimated probability of an alternative diagnosis, which primary care physicians and specialists might judge differently. The prevalence of thrombosis is low in primary care, and primary care physicians have a limited experience with it.

As a result, a specific primary care rule that included input from the patient history, physical examination, and a D-dimer test result (but without the subjective prior-probability estimation) was developed from data collected from 1,295 primary care patients with suspected DVT and referred for evaluation by ultrasonography. Of 16 variables, a model with 8 variables, including a quantitative D-dimer test result, was constructed using multivariate logistic regression analysis and excluding variables with a P value of >.10 based on the log likelihood ratio test. For the decision rule, named the primary care rule, the regression coefficients of the variables were transformed to integers according to their relative contributions to the risk estimation (Table 1⇑).5,10 The rule has been validated in various subgroups as well.11,12

A simple, rapid, bedside D-dimer test, using point-of-care assays performed with capillary blood, makes it possible to further enhance stratification of patients in the primary care setting.13 These qualitative D-dimer tests have a lower sensitivity and higher specificity than do quantitative tests.14

A diagnostic management study recently showed that primary care physicians can safely rule out DVT in approximately one-half of patients who they suspect have DVT by using the primary care rule (Table 1⇑) and including a qualitative point-of-care D-dimer test.15 A direct comparison of the Wells rule with the primary care rule combined with a point-of-care D-dimer test in an unselected primary care population has never been performed.16 We therefore compared the safety and efficiency of both rules to rule out a diagnosis of DVT in primary care patients using the data from the above-mentioned study15 to determine which of these rules performs best. Because the Wells rule was derived and validated without D-dimer testing, and the primary care rule was derived and validated with quantitative D-dimer testing, we assessed both rules without D-dimer testing and then with a point-of-care qualitative D-dimer test.

METHODS

Study Population

The study included 1,086 unselected patients with clinically suspected DVT seen by more than 300 general practitioners in the Netherlands. The study’s objective was to establish the safety and efficiency of ruling out DVT in primary care patients in a true management setting. The main results have been published elsewhere.15 Patients were eligible if they had 1 or more of the following symptoms: swelling, redness, or pain of the lower extremity. Patients were excluded if they were younger than 18 years or had received low-molecular-weight heparin or vitamin K antagonists. The study was approved by the local review boards.

Data Collection

During the patient encounter, the primary care physicians registered all data needed to calculate the score of both decision rules, their most likely diagnosis, and the results of a D-dimer test on specific case record forms. All D-dimer testing was performed using a rapid point-of-care D-dimer assay (Clearview Simplify D-dimer Assay, Inverness Medical, Bedford, United Kingdom). Patient management was based on the primary care rule as calculated by the attending physician. Patients with scores of 3 or less were not referred for ultrasonography and were not prescribed anticoagulant treatment, whereas patients with scores of 4 or more were referred for compression ultrasonography. The case record forms were forwarded to the investigators immediately. Patients were followed up after 5 to 9 days by their physician.

Three months after entering the study, all patients received a questionnaire addressing signs and symptoms of venous thromboembolism. Patients who did not respond (30%) were contacted through their general practitioners. Additional medical information was obtained about the patients from their general practitioners if any venous thromboembolic event was suspected. During 90 days of follow-up, venous thromboembolic complications and death caused by a possible thromboembolic event, confirmed by an independent adjudication committee, were recorded for all patients.

Calculation of Both Scores

To compare the safety and efficiency of the 2 rules, we calculated each patient’s score on the Wells rule and recalculated the score on the primary care rule. The last item of the Wells rule (an alternative diagnosis as likely or more likely than DVT) was not explicitly coded by the primary care physicians. For this analysis, an alternate diagnosis was coded when the physician registered an alternative diagnosis from a prespecified list of 9 possible diagnoses.

For the Wells rule, patients with a score of 1 or less and a negative D-dimer result were assigned to the low-risk group, and patients with a score of 2 or more or a positive D-dimer result were assigned to the high-risk group. For the primary care rule, a score of 3 or less and a negative D-dimer result indicated a low risk, and a score of 4 or more or a positive D-dimer result, a high risk. Originally a D-dimer test result was incorporated in the primary care rule (Table 1⇑),5 whereas in the Wells rule it was taken into account after the clinical score was estimated. To be able to make a direct comparison between both rules, we computed the score of the primary care rule with and without the D-dimer test result.

Missing Data

A total of 2.7% of the patients had a missing values for 1 or more of the items included in the 2 rules. Because deleting records with missing values not only leads to reduced power but also to biased results,17–19 missing values were handled with multiple imputation, using the SAS procedure MI (SAS/STAT 9.2, SAS Institute, Cary, North Carolina).

Outcome

We assessed the safety of the Wells rule and the primary care rule by calculating the number of patients who during 3 months of follow-up had a missed diagnosis of a thromboembolic event defined as symptomatic venous thromboembolism, including fatal pulmonary embolism, nonfatal pulmonary embolism, and deep venous thrombosis. We also calculated the efficiency of both rules by comparing the number of patients that needed referral for ultrasonography.

RESULTS

Of the 1,086 patients, 58 met 1 or more of the exclusion criteria, and in another 26 patients, management was not completed according to protocol (eg, management without a decision rule and unsuccessful or other than point-of-care D-dimer testing).15

The data from the remaining 1,002 patients (97%) were used for our analysis (Figure 1⇓). The mean age of included patients was 58 years, and 37% were male. Suspicion of deep venous thrombosis was based on complaints of leg pain (87%) and leg swelling (78%). The median duration of symptoms was 5 days. Of 1,002 patients, 136 (14%) had DVT confirmed by objective testing. Three patients were lost to follow-up.

Figure 1.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 1.

Study flow chart

Without including the D-dimer assay result, 607 patients (61%) received scores indicating low risk of suspected DVT in both rules, and 130 (13%) received scores indicating high-risk (Table 2⇓). In 265 patients (26%) the rules were discordant: the Wells score was high but the primary care score low in 243 patients (24%), whereas in 22 patients (2%) the primary care score was high but the Wells score was low.

View this table:
  • View inline
  • View popup
Table 2.

Concordance Between the Wells Rule and Primary Care Rule Without the D-Dimer Test

Without additional D-dimer testing, by applying the Wells rule, 373 patients (37%) were at high risk for DVT (score ≥1), whereas by applying the clinical items of the primary care rule, 152 (15%) were at high risk (score ≥4) These patients must be referred for ultrasonography regardless of D-dimer test results. In the patients not assessed as being at high risk for DVT, the D-dimer test was negative in 447 of 629 (71%) for the Wells rule and in 495 of 850 (58%) for the primary care rule. These patients would not need a diagnostic ultrasonography. This difference was significant (McNemar test; P <.001).

For both rules we found that 7 thromboembolic events occurred within the 3 months of follow-up in patients with a low score on the clinical items and a negative D-dimer: 7 of 447 (1.6%) for the Wells rule and 7 of 495 (1.4%) for the primary care rule (Table 3⇓). Of these 7 patients, 4 would be missed by both rules, whereas in 3 patients the results of the decision rules were discordant.

View this table:
  • View inline
  • View popup
Table 3.

Patients With Low Scores on Both Rules, With and Without a Negative D-Dimer Result, and (Missed) Thromboembolic Events

When applying the decision rules and D-dimer testing, 555 patients (55%) would be referred by the Wells rule compared with 507 (51%) by the primary care rule (McNemar test; P <.001). Of the 555 patients who would be referred for ultrasonography by the Wells rule, 129 (23%) had DVT confirmed compared with 129 of 507 (25%) when applying the primary care rule, a nonsignificant difference. (P = .40)

DISCUSSION

If only those patients with a low score and a negative D-dimer test were not referred for ultrasonography, DVT would have been missed in 1.6% with the Wells rule and in 1.4% with the primary care rule. These percentages of missed cases are comparable to that of ultrasonography only, implying that the safety of both decision rules is comparable to that of objective testing.20 To achieve these results, fewer patients need D-dimer testing when using the Wells rule, but 4% more will have to be referred for compression ultrasonography. For 100 patients a primary care physician has either to use 22 more D-dimer assays at a cost of $220 (assuming $10 per assay) when applying the primary care rule (85 high-scoring patients compared with 63 high-scoring patients with the Wells rule) or to refer 4 more patients for ultrasonography at a cost of $240 (assuming $60 per procedure) when using the Wells rule (55 high-scoring patients compared with 51 high-scoring patients with the primary care rule). Expressed differently, to save 1 referral for compression ultrasonography, an additional 5 or 6 D-dimer tests have to be performed when using the primary care rule.

Even though patients in our study were managed using the primary care rule, we believe that our findings are robust. In our large cohort of primary care patients, all data were recorded prospectively, and only 3 of 1,002 cases were lost to follow-up. Although we could not ascertain that every consecutive patient was included, it is likely that our cohort is representative for all patients seen in primary care. Furthermore, we applied blinded assessment of outcomes by using ultrasonography or an independent adjudication committee that was not aware of the diagnostic procedure.

To appreciate our results, however, a few aspects need to be addressed. First, the items for both rules were recorded simultaneously, and we calculated the scores for both rules centrally and independently. Although the case record form was designed in such a way that clinical data were collected before D-dimer testing was performed, we cannot exclude that attending physicians documented the ”presence of an alternative diagnosis,” one of the most important items of the Wells rule, knowing the result of the primary care rule and of the D-dimer test. Usually such bias leads to a dilution of the difference between both tests, ie, the accuracy of the Wells rule and primary care rule become more alike.21–23 The D-dimer test result, however, will also be available in everyday practice, and given that the positive predictive value of the primary care rule for the clinical items is only 36%15 and the negative predictive value is 91.7% (compared with 87.5% in the complete study population), the influence of this possible bias must not be exaggerated.

Second, the primary care rule was developed and validated as a comprehensive instrument that included clinical items and a quantitative D-dimer test. We compared the original Wells rule with the primary care rule without the D-dimer test by leaving out the D-dimer assay from the originally developed rule. As a result, the relative weights of the remaining items would likely be higher because part of the information covered by the deleted D-dimer test would be included by the other items. We did not adjust for this likelihood, possibly underestimating the performance of the primary care rule without the D-dimer assay compared with the Wells rule.

Finally, judged against previous studies carried out with quantitative tests, the Wells rule and point-of-care D-dimer testing performed better than expected,9,11 in that our results were more similar to those of earlier studies in secondary care.24 Our findings could be explained by a different performance of the point-of-care D-dimer test. Other potential explanations might be the direct comparison of both rules in this study and a different case mix. We included all patients suspected of having a DVT by their primary care physician, whereas in most previous studies patients were included when a primary care physician judged ultrasound testing to be necessary.24

The overall prevalence of 14% confirmed venous thromboembolic events strengthens the external validity of our findings. This prevalence is somewhat lower than found in earlier studies, probably because we performed a primary care–based study. D-dimer testing was performed with capillary whole blood using a point-of-care assay. In this way D-dimer measurement could be performed in the general practitioner’s office or at the patient’s home. The D-dimer test alone in this setting had a sensitivity of 86% and a specificity of 61%.15 The relatively high specificity contributed to a good clinical efficiency, ie, a relatively large proportion of patients could safely be spared referral for ultrasonography. Using another (less-specific) assay, as was the case in previous studies that used a laboratory based D-dimer test with venous blood, might result in more referrals for imaging.25

This study shows that DVT can safely be ruled out in primary care by using either decision rule. A low clinical probability, in combination with a negative point-of-care D-dimer test result, spares almost 50% of the patients traveling to a secondary care facility for ultrasonography.

When using the primary care rule, in every 100 patients at least 4 ultrasound procedures can be prevented at the cost of 22 additional D-dimer assays (5 to 6 assays per ultrasound test spared). Direct medical costs per patient thus will be about the same, but when using the primary care rule, fewer patients will be referred for ultrasonography. The relatively compact primary care rule, which does not require a subjective prior-probability estimation, therefore seems more convenient for both patients and for physicians.

Footnotes

  • Conflicts of interest: authors report none.

  • Funding support: This study was supported by The Netherlands Organization for Scientific Research (ZON-MW), grant No. 945-04-009.

  • Received for publication October 23, 2009.
  • Revision received July 31, 2010.
  • Accepted for publication August 27, 2010.
  • © 2011 Annals of Family Medicine, Inc.

REFERENCES

  1. ↵
    Huerta C, Johansson S, Wallander MA, García Rodríguez LA. Risk factors and short-term mortality of venous thromboembolism diagnosed in the primary care setting in the United Kingdom. Arch Intern Med. 2007;167(9):935–943.
    OpenUrlCrossRefPubMed
  2. Kilroy DA, Ireland S, Reid P, Goodacre S, Morris F. Emergency department investigation of deep vein thrombosis. Emerg Med J. 2003;20(1):29–32.
    OpenUrlAbstract/FREE Full Text
  3. Prandoni P, Lensing AW, Cogo A, et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med. 1996;125(1):1–7.
    OpenUrlCrossRefPubMed
  4. ↵
    White RH. The epidemiology of venous thromboembolism. Circulation. 2003;107(23)(Suppl 1):I4–I8.
    OpenUrlPubMed
  5. ↵
    Oudega R, Moons KG, Hoes AW. Ruling out deep venous thrombosis in primary care. A simple diagnostic algorithm including D-dimer testing. Thromb Haemost. 2005;94(1):200–205.
    OpenUrlPubMed
  6. ↵
    Kraaijenhagen RA, Piovella F, Bernardi E, et al. Simplification of the diagnostic management of suspected deep vein thrombosis. Arch Intern Med. 2002;162(8):907–911.
    OpenUrlCrossRefPubMed
  7. ↵
    Wells PS, Owen C, Doucette S, Fergusson D, Tran H. Does this patient have deep vein thrombosis? JAMA. 2006;295(2):199–207.
    OpenUrlCrossRefPubMed
  8. ↵
    Ten Cate-Hoek AJ, Prins MH. Management studies using a combination of D-dimer test result and clinical probability to rule out venous thromboembolism: a systematic review. J Thromb Haemost. 2005;3(11):2465–2470.
    OpenUrlCrossRefPubMed
  9. ↵
    Oudega R, Hoes AW, Moons KG. The Wells rule does not adequately rule out deep venous thrombosis in primary care patients. Ann Intern Med. 2005;143(2):100–107.
    OpenUrlCrossRefPubMed
  10. ↵
    Oudega R, Hoes AW, Toll DB, Moons KG. The value of clinical findings and D-dimer tests in diagnosing deep vein thrombosis in primary care. Semin Thromb Hemost. 2006;32(7):673–677.
    OpenUrlCrossRefPubMed
  11. ↵
    Toll DB, Oudega R, Bulten RJ, Hoes AW, Moons KG. Excluding deep vein thrombosis safely in primary care. J Fam Pract. 2006;55(7): 613–618.
    OpenUrlPubMed
  12. ↵
    Toll DB, Oudega R, Vergouwe Y, Moons KG, Hoes AW. A new diagnostic rule for deep vein thrombosis: safety and efficiency in clinically relevant subgroups. Fam Pract. 2008;25(1):3–8.
    OpenUrlAbstract/FREE Full Text
  13. ↵
    Van Der Velde EF, Wichers IM, Toll DB, Van Weert HC, Büller HR. Feasibility and accuracy of a rapid ‘point-of-care’ D-dimer test performed with a capillary blood sample. J Thromb Haemost. 2007;5(6): 1327–1330.
    OpenUrlCrossRefPubMed
  14. ↵
    Geersing GJ, Janssen KJ, Oudega R, et al. Excluding venous thromboembolism using point of care D-dimer tests in outpatients: a diagnostic meta-analysis. BMJ. 2009;339:b2990.
    OpenUrlAbstract/FREE Full Text
  15. ↵
    Büller HR, Ten Cate-Hoek AJ, Hoes AW, et al; AMUSE (Amsterdam Maastricht Utrecht Study on thromboEmbolism) Investigators. Safely ruling out deep venous thrombosis in primary care. Ann Intern Med. 2009;150(4):229–235.
    OpenUrlCrossRefPubMed
  16. ↵
    Reilly BM, Evans AT. Much ado about (doing) nothing. Ann Intern Med. 2009;150(4):270–271.
    OpenUrlCrossRefPubMed
  17. ↵
    Gornbein JA, Lazaro CG, Little RJ. Incomplete data in repeated measures analysis. Stat Methods Med Res. 1992;1(3):275–295.
    OpenUrlAbstract/FREE Full Text
  18. Greenland S, Finkle WD. A critical look at methods for handling missing covariates in epidemiologic regression analyses. Am J Epidemiol. 1995;142(12):1255–1264.
    OpenUrlAbstract/FREE Full Text
  19. ↵
    Donders AR, van der Heijden GJ, Stijnen T, Moons KG. Review: a gentle introduction to imputation of missing values. J Clin Epidemiol. 2006;59(10):1087–1091.
    OpenUrlCrossRefPubMed
  20. ↵
    Goodacre S, Sampson F, Thomas S, van Beek E, Sutton A. Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis. BMC Med Imaging. 2005;5:6.
    OpenUrlCrossRefPubMed
  21. ↵
    Begg CB, McNeil BJ. Assessment of radiologic tests: control of bias and other design considerations. Radiology. 1988;167(2):565–569.
    OpenUrlPubMed
  22. Swets JA. Measuring the accuracy of diagnostic systems. Science. 1988;240(4857):1285–1293.
    OpenUrlAbstract/FREE Full Text
  23. ↵
    Moons KG, Grobbee DE. When should we remain blind and when should our eyes remain open in diagnostic studies? J Clin Epidemiol. 2002;55(7):633–636.
    OpenUrlCrossRefPubMed
  24. ↵
    Goodacre S, Sutton AJ, Sampson FC. Meta-analysis: The value of clinical assessment in the diagnosis of deep venous thrombosis. Ann Intern Med. 2005;143(2):129–139.
    OpenUrlPubMed
  25. ↵
    Goodacre S, Sampson FC, Sutton AJ, Mason S, Morris F. Variation in the diagnostic performance of D-dimer for suspected deep vein thrombosis. QJM. 2005;98(7):513–527.
    OpenUrlAbstract/FREE Full Text
PreviousNext
Back to top

In this issue

The Annals of Family Medicine: 9 (1)
The Annals of Family Medicine: 9 (1)
Vol. 9, Issue 1
1 Jan 2011
  • Table of Contents
  • Index by author
  • In Brief
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Annals of Family Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Comparing the Diagnostic Performance of 2 Clinical Decision Rules to Rule Out Deep Vein Thrombosis in Primary Care Patients
(Your Name) has sent you a message from Annals of Family Medicine
(Your Name) thought you would like to see the Annals of Family Medicine web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
1 + 6 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Comparing the Diagnostic Performance of 2 Clinical Decision Rules to Rule Out Deep Vein Thrombosis in Primary Care Patients
Eit Frits van der Velde, Diane B. Toll, Arina J. ten Cate-Hoek, Ruud Oudega, Henri E. J. H. Stoffers, Patrick M. Bossuyt, Harry R. Büller, Martin H. Prins, Arno W. Hoes, Karel G. M. Moons, Henk C. P. M. van Weert
The Annals of Family Medicine Jan 2011, 9 (1) 31-36; DOI: 10.1370/afm.1198

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Get Permissions
Share
Comparing the Diagnostic Performance of 2 Clinical Decision Rules to Rule Out Deep Vein Thrombosis in Primary Care Patients
Eit Frits van der Velde, Diane B. Toll, Arina J. ten Cate-Hoek, Ruud Oudega, Henri E. J. H. Stoffers, Patrick M. Bossuyt, Harry R. Büller, Martin H. Prins, Arno W. Hoes, Karel G. M. Moons, Henk C. P. M. van Weert
The Annals of Family Medicine Jan 2011, 9 (1) 31-36; DOI: 10.1370/afm.1198
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • INTRODUCTION
    • METHODS
    • RESULTS
    • DISCUSSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • eLetters
  • Info & Metrics
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Role of Physical Therapists in the Management of Individuals at Risk for or Diagnosed With Venous Thromboembolism: Evidence-Based Clinical Practice Guideline
  • Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis
  • The D-Dimer test in combination with a decision rule for ruling out deep vein thrombosis in primary care: diagnostic technology update
  • Management of deep vein thrombosis and prevention of post-thrombotic syndrome
  • In This Issue: Clinical Decision Support
  • Google Scholar

More in this TOC Section

  • Family-Based Interventions to Promote Weight Management in Adults: Results From a Cluster Randomized Controlled Trial in India
  • Teamwork Among Primary Care Staff to Achieve Regular Follow-Up of Chronic Patients
  • Shared Decision Making Among Racially and/or Ethnically Diverse Populations in Primary Care: A Scoping Review of Barriers and Facilitators
Show more Original Research

Similar Articles

Subjects

  • Methods:
    • Quantitative methods
  • Other topics:
    • Communication / decision making

Content

  • Current Issue
  • Past Issues
  • Early Access
  • Plain-Language Summaries
  • Multimedia
  • Podcast
  • Articles by Type
  • Articles by Subject
  • Supplements
  • Calls for Papers

Info for

  • Authors
  • Reviewers
  • Job Seekers
  • Media

Engage

  • E-mail Alerts
  • e-Letters (Comments)
  • RSS
  • Journal Club
  • Submit a Manuscript
  • Subscribe
  • Family Medicine Careers

About

  • About Us
  • Editorial Board & Staff
  • Sponsoring Organizations
  • Copyrights & Permissions
  • Contact Us
  • eLetter/Comments Policy

© 2025 Annals of Family Medicine