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Research ArticleOriginal Research

COPD Population in US Primary Care: Data From the Optimum Patient Care DARTNet Research Database and the Advancing the Patient Experience in COPD Registry

Wilson D. Pace, Elias Brandt, Victoria A. Carter, Ku-Lang Chang, Chelsea L. Edwards, Alexander Evans, Chester Fox, Gabriela Gaona, MeiLan K. Han, Alan G. Kaplan, Rachel Kent, Janwillem W. H. Kocks, Maja Kruszyk, Chantal E. Le Lievre, Tessa Li Voti, Cathy Mahle, Barry Make, Amanda R. Ratigan, Asif Shaikh, Neil Skolnik, Brooklyn Stanley, Barbara P. Yawn and David B. Price
The Annals of Family Medicine July 2022, 20 (4) 319-327; DOI: https://doi.org/10.1370/afm.2829
Wilson D. Pace
1DARTNet Institute, Aurora, Colorado;
2University of Colorado Denver, Denver, Colorado;
MD
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Elias Brandt
1DARTNet Institute, Aurora, Colorado;
MSc
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Victoria A. Carter
3Optimum Patient Care, Cambridge, United Kingdom;
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Ku-Lang Chang
4University of Florida College of Medicine, Gainesville, Florida;
MD
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Chelsea L. Edwards
5Optimum Patient Care, Brisbane, Australia;
PhD
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Alexander Evans
3Optimum Patient Care, Cambridge, United Kingdom;
MSc
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Chester Fox
1DARTNet Institute, Aurora, Colorado;
6University at Buffalo, Buffalo, New York;
MD
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Gabriela Gaona
1DARTNet Institute, Aurora, Colorado;
MPH
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MeiLan K. Han
7University of Michigan, Ann Arbor, Michigan;
MD
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Alan G. Kaplan
8Observational & Pragmatic Research Institute, Singapore;
9Family Physician Airways Group of Canada, Stouffville, Ontario, Canada;
10University of Toronto, Toronto, Canada;
MD
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Rachel Kent
1DARTNet Institute, Aurora, Colorado;
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Janwillem W. H. Kocks
8Observational & Pragmatic Research Institute, Singapore;
11General Practitioners Research Institute, Groningen, The Netherlands;
MD, PhD
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Maja Kruszyk
5Optimum Patient Care, Brisbane, Australia;
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Chantal E. Le Lievre
5Optimum Patient Care, Brisbane, Australia;
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Tessa Li Voti
3Optimum Patient Care, Cambridge, United Kingdom;
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Cathy Mahle
12Boehringer Ingelheim, Ridgefield, Connecticut;
PhD, MBA
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Barry Make
13Department of Medicine, National Jewish Health, Denver, Colorado;
MD
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Amanda R. Ratigan
1DARTNet Institute, Aurora, Colorado;
PhD, MPH
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Asif Shaikh
12Boehringer Ingelheim, Ridgefield, Connecticut;
MD, MPH
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Neil Skolnik
14Thomas Jefferson University, Woodbury, New Jersey;
15Abington Jefferson Health, Jenkintown, Pennsylvania;
MD
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Brooklyn Stanley
3Optimum Patient Care, Cambridge, United Kingdom;
8Observational & Pragmatic Research Institute, Singapore;
MSc
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Barbara P. Yawn
16University of Minnesota, Minneapolis, Minnesota;
17COPD Foundation, Washington, DC;
MD, MSc, MSPH
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David B. Price
8Observational & Pragmatic Research Institute, Singapore;
18Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
FRCGP
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  • For correspondence: dprice@opri.sg
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Jump to comment:

  • RE: Treatment for COPD
    Sheryl M Flynn
    Published on: 27 September 2022
  • Manipulating Gut Biomes In Real-Life COPD Patients Are The Key
    Deepak Gupta
    Published on: 04 September 2022
  • Published on: (27 September 2022)
    Page navigation anchor for RE: Treatment for COPD
    RE: Treatment for COPD
    • Sheryl M Flynn, CEO, Blue Marble Health

    Thank you for a compelling article. While I understand that this article explored treatment in the form of drug therapy, I wonder if the authors captured data related to pulmonary rehab as another therapy option for adults with COPD. If so, will the authors report on these findings in the future?

    Competing Interests: None declared.
  • Published on: (4 September 2022)
    Page navigation anchor for Manipulating Gut Biomes In Real-Life COPD Patients Are The Key
    Manipulating Gut Biomes In Real-Life COPD Patients Are The Key
    • Deepak Gupta, Anesthesiologist, Wayne State University/Detroit Medical Center

    The practice of medicine has long been looking and doing it the wrong way and anesthesiologists like me have been no saints too. Our practice has been ignoring the role of bugs against bugs for so long that we do not even discuss their role in managing our diseases. However, it is high time that we initiate discussions about manipulating our gut biomes not only in real-life COPD patients but also in all others considering that none's eating behavior has remained the same as what it used to be among our not-too-distant forebears who had evolved fighting and surviving with many more bugs than we are exposed to. The bottom-line is this that future clinical trials as well as clinical practice among real-life COPD patients have to not only include physical barriers like masks and chemical crusaders like antibiotics but also biological guards like prebiotics-probiotics and spiritual guides like stressbusters because without holistic approach, millennials may inexplicably suffer while surviving the onslaught of evolving diseases by overlooking what their forebears had learned to pass on to their descendants over millenniums.
    Suggested Reading:
    Avalos-Fernandez M, Alin T, Métayer C, Thiébaut R, Enaud R, Delhaes L. The respiratory microbiota alpha-diversity in chronic lung diseases: first systematic review and meta-analysis. Respir Res. 2022;23(1):214. Published 2022 Aug 23. doi:10.1186/s12931-022-02132-4
    Millares L, Monso E. The Microbiome in COPD: Emerging...

    Show More

    The practice of medicine has long been looking and doing it the wrong way and anesthesiologists like me have been no saints too. Our practice has been ignoring the role of bugs against bugs for so long that we do not even discuss their role in managing our diseases. However, it is high time that we initiate discussions about manipulating our gut biomes not only in real-life COPD patients but also in all others considering that none's eating behavior has remained the same as what it used to be among our not-too-distant forebears who had evolved fighting and surviving with many more bugs than we are exposed to. The bottom-line is this that future clinical trials as well as clinical practice among real-life COPD patients have to not only include physical barriers like masks and chemical crusaders like antibiotics but also biological guards like prebiotics-probiotics and spiritual guides like stressbusters because without holistic approach, millennials may inexplicably suffer while surviving the onslaught of evolving diseases by overlooking what their forebears had learned to pass on to their descendants over millenniums.
    Suggested Reading:
    Avalos-Fernandez M, Alin T, Métayer C, Thiébaut R, Enaud R, Delhaes L. The respiratory microbiota alpha-diversity in chronic lung diseases: first systematic review and meta-analysis. Respir Res. 2022;23(1):214. Published 2022 Aug 23. doi:10.1186/s12931-022-02132-4
    Millares L, Monso E. The Microbiome in COPD: Emerging Potential for Microbiome-Targeted Interventions. Int J Chron Obstruct Pulmon Dis. 2022;17:1835-1845. Published 2022 Aug 12. doi:10.2147/COPD.S371958
    Kotlyarov S. Role of Short-Chain Fatty Acids Produced by Gut Microbiota in Innate Lung Immunity and Pathogenesis of the Heterogeneous Course of Chronic Obstructive Pulmonary Disease. Int J Mol Sci. 2022;23(9):4768. Published 2022 Apr 26. doi:10.3390/ijms23094768
    Qu L, Cheng Q, Wang Y, Mu H, Zhang Y. COPD and Gut-Lung Axis: How Microbiota and Host Inflammasome Influence COPD and Related Therapeutics. Front Microbiol. 2022;13:868086. Published 2022 Apr 1. doi:10.3389/fmicb.2022.868086
    Ding K, Chen J, Zhan W, et al. Microbiome Links Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease and Dietary Fiber via the Gut-Lung Axis: A Narrative Review. COPD. 2021;19(1):10-17. doi:10.1080/15412555.2021.2019208
    Gokulan K, Joshi M, Khare S, Bartter T. Lung microbiome, gut-lung axis and chronic obstructive pulmonary disease. Curr Opin Pulm Med. 2022;28(2):134-138. doi:10.1097/MCP.0000000000000853
    Vaughan A, Frazer ZA, Hansbro PM, Yang IA. COPD and the gut-lung axis: the therapeutic potential of fibre. J Thorac Dis. 2019;11(Suppl 17):S2173-S2180. doi:10.21037/jtd.2019.10.40
    Sonnenburg J, Sonnenburg E. The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-term Health. 1st ed. Penguin Press; 2015.

    Show Less
    Competing Interests: None declared.
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The Annals of Family Medicine: 20 (4)
The Annals of Family Medicine: 20 (4)
Vol. 20, Issue 4
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COPD Population in US Primary Care: Data From the Optimum Patient Care DARTNet Research Database and the Advancing the Patient Experience in COPD Registry
Wilson D. Pace, Elias Brandt, Victoria A. Carter, Ku-Lang Chang, Chelsea L. Edwards, Alexander Evans, Chester Fox, Gabriela Gaona, MeiLan K. Han, Alan G. Kaplan, Rachel Kent, Janwillem W. H. Kocks, Maja Kruszyk, Chantal E. Le Lievre, Tessa Li Voti, Cathy Mahle, Barry Make, Amanda R. Ratigan, Asif Shaikh, Neil Skolnik, Brooklyn Stanley, Barbara P. Yawn, David B. Price
The Annals of Family Medicine Jul 2022, 20 (4) 319-327; DOI: 10.1370/afm.2829

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COPD Population in US Primary Care: Data From the Optimum Patient Care DARTNet Research Database and the Advancing the Patient Experience in COPD Registry
Wilson D. Pace, Elias Brandt, Victoria A. Carter, Ku-Lang Chang, Chelsea L. Edwards, Alexander Evans, Chester Fox, Gabriela Gaona, MeiLan K. Han, Alan G. Kaplan, Rachel Kent, Janwillem W. H. Kocks, Maja Kruszyk, Chantal E. Le Lievre, Tessa Li Voti, Cathy Mahle, Barry Make, Amanda R. Ratigan, Asif Shaikh, Neil Skolnik, Brooklyn Stanley, Barbara P. Yawn, David B. Price
The Annals of Family Medicine Jul 2022, 20 (4) 319-327; DOI: 10.1370/afm.2829
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